GREMLIN Database
DUF3169 - Protein of unknown function (DUF3169)
PFAM: PF11368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 250 (246)
Sequences: 537 (385)
Seq/√Len: 24.6
META: 0.525

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_G187_S4.1141.00
10_L14_S3.6601.00
188_C196_I3.6551.00
177_D183_K3.2701.00
6_K9_L3.0781.00
184_W188_C3.0311.00
228_G231_A2.9841.00
116_L120_I2.9041.00
234_V238_I2.7260.99
173_G184_W2.6450.99
158_V162_K2.6120.99
116_L236_G2.6040.99
173_G180_F2.4610.99
174_S177_D2.4410.98
158_V175_V2.4300.98
19_G22_G2.3780.98
180_F187_S2.3750.98
173_G188_C2.3470.98
82_D86_D2.3320.98
222_S229_Q2.2540.97
174_S183_K2.2340.97
203_A207_N2.2200.97
207_N242_I2.1900.97
9_L12_L2.1290.96
61_V65_I2.0950.96
218_L235_V2.0720.96
14_S17_I2.0550.95
177_D180_F2.0080.95
169_P184_W1.9530.94
157_Q161_V1.8150.91
76_K79_S1.7780.90
12_L16_L1.7580.90
63_L86_D1.7570.90
86_D220_L1.7160.89
180_F188_C1.7140.89
3_A7_F1.7080.88
165_K168_N1.6770.87
180_F184_W1.6760.87
211_L235_V1.6620.87
22_G26_G1.6230.86
162_K168_N1.6140.85
8_L15_A1.6120.85
42_K76_K1.6080.85
208_N243_N1.5920.85
19_G23_F1.5890.84
212_P240_I1.5820.84
41_L45_L1.5820.84
171_K187_S1.5740.84
184_W239_W1.5690.84
171_K184_W1.5570.83
101_S104_T1.5470.83
3_A174_S1.5450.83
73_K99_K1.5370.82
227_T231_A1.5060.81
218_L227_T1.5030.81
196_I246_Y1.5000.81
165_K180_F1.4980.81
191_G194_Q1.4630.79
206_L245_S1.4350.78
231_A239_W1.4200.77
62_I128_L1.4190.77
81_Y86_D1.4180.77
233_L237_V1.4120.77
191_G221_L1.3970.76
239_W242_I1.3850.75
197_Y229_Q1.3760.75
184_W228_G1.3570.74
218_L221_L1.3450.73
185_L197_Y1.3390.73
38_S41_L1.3350.72
155_I193_K1.3260.72
182_K204_Y1.3210.72
70_F73_K1.3010.70
131_S134_T1.2950.70
60_G67_T1.2900.70
162_K165_K1.2880.70
64_I148_I1.2750.69
207_N238_I1.2640.68
211_L238_I1.2520.67
69_Y147_L1.2210.65
21_L24_F1.1990.64
40_D44_L1.1940.64
196_I199_A1.1860.63
226_G238_I1.1830.63
13_L41_L1.1770.62
82_D87_D1.1720.62
122_V129_N1.1710.62
180_F228_G1.1670.62
161_V191_G1.1650.62
157_Q177_D1.1530.61
161_V173_G1.1420.60
151_L166_K1.1320.59
206_L210_V1.1310.59
176_Y193_K1.1310.59
207_N245_S1.1260.59
135_L138_S1.1240.59
97_E172_L1.1200.58
218_L231_A1.1100.58
20_F23_F1.1090.58
178_P197_Y1.1040.57
188_C228_G1.1030.57
71_Y177_D1.1010.57
218_L222_S1.0790.56
169_P239_W1.0670.55
174_S180_F1.0660.55
172_L193_K1.0640.55
172_L191_G1.0630.54
197_Y200_S1.0510.54
107_S237_V1.0490.53
193_K216_I1.0460.53
8_L60_G1.0400.53
165_K173_G1.0340.52
119_G242_I1.0290.52
165_K174_S1.0290.52
171_K192_E1.0250.52
123_S200_S1.0250.52
204_Y246_Y1.0240.52
195_A199_A1.0080.51
26_G106_A1.0010.50
221_L225_F0.9980.50
211_L239_W0.9970.50
215_Y236_G0.9850.49
3_A211_L0.9850.49
43_E62_I0.9800.49
165_K191_G0.9730.48
25_V235_V0.9720.48
158_V174_S0.9620.47
191_G198_E0.9580.47
62_I80_L0.9540.47
161_V180_F0.9520.47
130_D133_G0.9490.46
28_F63_L0.9400.46
74_A96_M0.9370.45
139_F143_L0.9360.45
203_A245_S0.9320.45
82_D89_L0.9280.45
161_V196_I0.9250.45
231_A242_I0.9220.44
10_L58_L0.9220.44
184_W196_I0.9220.44
23_F185_L0.9210.44
203_A208_N0.9150.44
58_L210_V0.9110.44
71_Y163_L0.9090.43
109_I224_L0.9060.43
196_I239_W0.9050.43
20_F198_E0.9020.43
8_L178_P0.9020.43
115_L126_I0.9010.43
15_A40_D0.8960.43
24_F62_I0.8940.42
18_G22_G0.8920.42
61_V64_I0.8890.42
178_P229_Q0.8800.41
17_I62_I0.8760.41
172_L187_S0.8740.41
14_S22_G0.8710.41
11_L40_D0.8620.40
227_T232_I0.8610.40
81_Y85_D0.8600.40
180_F194_Q0.8570.40
194_Q197_Y0.8560.40
9_L47_F0.8550.40
46_P65_I0.8540.40
75_K79_S0.8540.40
3_A176_Y0.8440.39
228_G239_W0.8440.39
18_G189_D0.8410.39
98_R240_I0.8400.39
173_G229_Q0.8390.39
9_L13_L0.8390.39
148_I186_D0.8350.38
152_L233_L0.8300.38
96_M239_W0.8280.38
184_W187_S0.8270.38
174_S211_L0.8220.37
220_L224_L0.8210.37
212_P231_A0.8180.37
15_A25_V0.8170.37
187_S214_L0.8110.37
79_S163_L0.8070.36
12_L133_G0.8070.36
11_L15_A0.8030.36
175_V203_A0.8030.36
90_N93_Y0.7970.36
69_Y73_K0.7960.36
194_Q198_E0.7950.36
169_P199_A0.7950.36
32_A80_L0.7940.36
159_R168_N0.7930.36
170_E177_D0.7920.35
19_G24_F0.7880.35
12_L56_I0.7870.35
192_E222_S0.7860.35
80_L84_E0.7860.35
86_D190_E0.7850.35
55_W167_L0.7840.35
33_E42_K0.7720.34
165_K171_K0.7680.34
52_I55_W0.7660.34
100_L188_C0.7580.33
214_L235_V0.7550.33
61_V86_D0.7530.33
134_T137_L0.7500.33
74_A103_G0.7490.33
146_F165_K0.7460.32
116_L233_L0.7450.32
66_L182_K0.7400.32
104_T118_L0.7400.32
63_L87_D0.7380.32
216_I234_V0.7360.32
190_E197_Y0.7320.32
100_L116_L0.7320.32
113_L201_Y0.7300.31
8_L87_D0.7270.31
108_N248_R0.7250.31
221_L229_Q0.7240.31
105_I224_L0.7190.31
44_L233_L0.7190.31
148_I154_I0.7150.31
83_E88_D0.7150.31
106_A204_Y0.7100.30
21_L223_L0.7050.30
118_L140_L0.7050.30
203_A219_F0.7030.30
197_Y231_A0.6990.30
165_K187_S0.6920.29
165_K177_D0.6910.29
218_L241_Y0.6910.29
187_S196_I0.6910.29
62_I240_I0.6900.29
181_Q184_W0.6900.29
218_L233_L0.6870.29
184_W199_A0.6870.29
165_K185_L0.6860.29
28_F216_I0.6810.29
83_E89_L0.6810.29
19_G138_S0.6810.29
14_S147_L0.6790.28
180_F191_G0.6790.28
39_L47_F0.6770.28
162_K212_P0.6770.28
210_V235_V0.6690.28
136_S220_L0.6690.28
161_V188_C0.6670.28
177_D197_Y0.6670.28
192_E218_L0.6650.28
76_K80_L0.6640.28
199_A246_Y0.6630.27
174_S215_Y0.6580.27
84_E88_D0.6580.27
11_L66_L0.6570.27
119_G207_N0.6570.27
215_Y239_W0.6560.27
72_R185_L0.6560.27
203_A249_E0.6550.27
193_K209_Y0.6540.27
35_E151_L0.6520.27
235_V239_W0.6480.27
16_L230_L0.6460.27
194_Q221_L0.6450.26
188_C239_W0.6440.26
115_L122_V0.6440.26
63_L109_I0.6430.26
56_I73_K0.6430.26
24_F67_T0.6400.26
81_Y163_L0.6400.26
59_L245_S0.6390.26
171_K180_F0.6370.26
105_I211_L0.6360.26
119_G201_Y0.6360.26
17_I41_L0.6330.26
40_D43_E0.6330.26
59_L102_Y0.6320.26
109_I128_L0.6280.26
5_K176_Y0.6280.26
177_D246_Y0.6270.25
21_L33_E0.6260.25
40_D113_L0.6230.25
193_K197_Y0.6230.25
24_F179_K0.6230.25
153_K163_L0.6220.25
199_A235_V0.6200.25
173_G221_L0.6200.25
222_S227_T0.6190.25
20_F25_V0.6160.25
20_F49_S0.6110.25
163_L167_L0.6100.25
203_A211_L0.6090.24
173_G191_G0.6090.24
132_H138_S0.6050.24
38_S44_L0.6020.24
191_G229_Q0.6000.24
85_D89_L0.5980.24
148_I207_N0.5960.24
25_V205_Q0.5950.24
28_F142_V0.5950.24
119_G165_K0.5950.24
12_L178_P0.5900.23
222_S228_G0.5860.23
35_E145_L0.5820.23
20_F24_F0.5820.23
10_L143_L0.5810.23
158_V231_A0.5790.23
131_S135_L0.5780.23
168_N215_Y0.5780.23
172_L184_W0.5760.23
86_D156_L0.5760.23
109_I147_L0.5740.23
12_L15_A0.5730.23
143_L226_G0.5720.23
100_L184_W0.5710.23
12_L216_I0.5710.23
22_G157_Q0.5700.22
115_L118_L0.5700.22
230_L234_V0.5690.22
179_K182_K0.5680.22
53_L62_I0.5670.22
146_F228_G0.5670.22
165_K170_E0.5660.22
72_R86_D0.5650.22
176_Y183_K0.5650.22
219_F232_I0.5610.22
17_I56_I0.5600.22
185_L188_C0.5580.22
15_A134_T0.5580.22
73_K216_I0.5580.22
173_G194_Q0.5570.22
173_G196_I0.5550.22
194_Q234_V0.5540.22
109_I140_L0.5530.22
172_L205_Q0.5510.22
139_F220_L0.5450.21
161_V187_S0.5450.21
172_L180_F0.5450.21
100_L196_I0.5410.21
141_L144_V0.5390.21
176_Y211_L0.5380.21
221_L227_T0.5380.21
72_R207_N0.5370.21
162_K167_L0.5370.21
86_D89_L0.5360.21
186_D206_L0.5340.21
211_L234_V0.5330.21
48_I109_I0.5320.21
202_K205_Q0.5260.20
8_L20_F0.5260.20
38_S59_L0.5250.20
23_F234_V0.5240.20
242_I248_R0.5220.20
173_G228_G0.5220.20
68_F94_D0.5210.20
200_S221_L0.5200.20
242_I246_Y0.5200.20
213_G241_Y0.5200.20
129_N144_V0.5200.20
121_S154_I0.5160.20
84_E90_N0.5150.20
180_F200_S0.5140.20
109_I240_I0.5130.20
225_F229_Q0.5090.20
140_L146_F0.5080.20
17_I59_L0.5080.20
190_E212_P0.5060.19
79_S83_E0.5030.19
11_L174_S0.5030.19
161_V167_L0.5020.19
172_L229_Q0.5010.19
115_L220_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.352 46.9 0.937 Contact Map
2kncA 1 0.204 24.7 0.946 Contact Map
4w6vA 1 0.264 23.7 0.946 Contact Map
3rlbA 1 0.332 22.7 0.947 Contact Map
4tkrA 2 0.316 16.7 0.95 Contact Map
4ikvA 1 0.256 12.6 0.952 Contact Map
4i0uA 4 0.248 9.9 0.955 Contact Map
4ev6A 3 0.256 9.4 0.955 Contact Map
3pcvA 3 0.376 9.2 0.955 Contact Map
4dx5A 3 0.592 8.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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