GREMLIN Database
DUF3164 - Protein of unknown function (DUF3164)
PFAM: PF11363 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 194 (193)
Sequences: 2085 (1643)
Seq/√Len: 118.3
META: 0.771

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D8_R4.9191.00
34_K178_E4.6901.00
111_E153_R4.0191.00
145_R162_R3.8251.00
32_K46_H3.3751.00
107_E153_R3.1731.00
102_K106_D2.9811.00
108_C112_W2.7271.00
180_D183_G2.5491.00
30_V188_I2.3481.00
36_L40_L2.1451.00
156_E159_E2.0661.00
178_E186_Q2.0291.00
23_D27_R2.0021.00
2_M12_E1.9871.00
180_D186_Q1.9121.00
29_I176_F1.8451.00
36_L39_Q1.8211.00
2_M20_K1.8131.00
104_L156_E1.8131.00
29_I47_A1.8131.00
21_L24_E1.7841.00
76_T83_K1.7731.00
103_A107_E1.7581.00
159_E163_D1.7551.00
2_M15_V1.7521.00
77_S81_R1.7261.00
83_K177_Y1.7201.00
35_E39_Q1.6871.00
62_Y163_D1.6561.00
33_A176_F1.6551.00
22_R96_E1.6541.00
15_V20_K1.6371.00
70_K90_D1.6261.00
13_E118_P1.5981.00
136_I141_V1.5901.00
33_A43_F1.5361.00
36_L43_F1.4911.00
19_D22_R1.4841.00
111_E151_D1.4731.00
27_R82_Y1.4401.00
1_Y9_L1.4331.00
126_D146_R1.4221.00
49_D53_A1.4131.00
109_L123_L1.4071.00
83_K185_Y1.4001.00
38_E42_R1.3991.00
140_R143_G1.3961.00
152_E156_E1.3871.00
37_S41_A1.3831.00
131_D135_N1.3731.00
28_E50_D1.3711.00
30_V176_F1.3701.00
150_D155_Q1.3541.00
85_Q177_Y1.3421.00
12_E20_K1.3351.00
81_R178_E1.3331.00
8_R14_L1.3211.00
177_Y187_P1.3111.00
107_E111_E1.3071.00
104_L153_R1.3021.00
137_N140_R1.2981.00
88_V170_S1.2971.00
30_V82_Y1.2891.00
87_A175_R1.2630.99
155_Q159_E1.2460.99
57_L60_E1.2350.99
52_A56_E1.2330.99
112_W117_R1.2120.99
27_R77_S1.2040.99
109_L113_S1.2020.99
3_K9_L1.1960.99
40_L190_L1.1870.99
55_V73_V1.1660.99
105_I158_M1.1420.99
129_Q140_R1.1390.99
21_L57_L1.1370.99
91_R171_K1.1210.99
179_R185_Y1.1060.99
93_T168_V1.1030.99
40_L192_I1.0920.98
122_A147_L1.0870.98
52_A172_T1.0820.98
120_L123_L1.0750.98
118_P121_R1.0750.98
24_E60_E1.0710.98
5_A80_G1.0610.98
98_L136_I1.0520.98
91_R170_S1.0490.98
126_D129_Q1.0470.98
17_P61_E1.0440.98
51_I75_L1.0350.98
180_D184_K1.0220.98
45_A49_D1.0180.98
11_P14_L1.0140.97
47_A174_I1.0120.97
125_N130_V1.0020.97
37_S40_L0.9910.97
42_R46_H0.9890.97
81_R185_Y0.9850.97
18_I97_R0.9840.97
50_D53_A0.9820.97
41_A45_A0.9690.97
27_R79_D0.9640.97
94_F98_L0.9640.97
58_S96_E0.9600.96
22_R54_F0.9570.96
92_I165_I0.9560.96
16_K148_E0.9530.96
3_K81_R0.9510.96
34_K38_E0.9470.96
12_E15_V0.9460.96
15_V78_F0.9450.96
126_D147_L0.9360.96
126_D140_R0.9290.96
18_I58_S0.9230.96
112_W119_E0.9050.95
100_A103_A0.9000.95
131_D137_N0.8970.95
178_E188_I0.8780.94
26_V75_L0.8740.94
11_P122_A0.8720.94
61_E97_R0.8710.94
18_I22_R0.8690.94
50_D60_E0.8680.94
6_K90_D0.8640.94
30_V84_V0.8580.94
32_K39_Q0.8550.93
129_Q137_N0.8520.93
186_Q189_P0.8450.93
22_R97_R0.8420.93
25_L29_I0.8400.93
142_L145_R0.8360.93
115_G118_P0.8350.93
2_M27_R0.8320.92
82_Y178_E0.8280.92
28_E32_K0.8190.92
105_I108_C0.8190.92
59_A66_L0.8180.92
102_K130_V0.8170.92
121_R125_N0.8090.91
29_I84_V0.8030.91
48_F172_T0.7980.91
17_P20_K0.7970.91
81_R181_E0.7960.91
77_S80_G0.7920.90
85_Q133_E0.7910.90
51_I86_V0.7910.90
21_L25_L0.7900.90
23_D78_F0.7870.90
89_A170_S0.7810.90
8_R11_P0.7770.90
24_E57_L0.7730.89
64_V103_A0.7710.89
127_A130_V0.7660.89
55_V75_L0.7640.89
10_V78_F0.7600.89
53_A60_E0.7530.88
32_K35_E0.7430.87
84_V176_F0.7430.87
154_W158_M0.7420.87
22_R95_D0.7380.87
104_L160_A0.7350.87
38_E41_A0.7230.86
43_F47_A0.7230.86
152_E155_Q0.7230.86
95_D166_Q0.7200.86
109_L153_R0.7190.86
145_R158_M0.7190.86
113_S120_L0.7180.86
58_S95_D0.7130.85
162_R165_I0.7090.85
114_E117_R0.7080.85
86_V172_T0.7080.85
119_E151_D0.7050.85
104_L108_C0.6960.84
142_L165_I0.6940.84
58_S97_R0.6930.84
76_T185_Y0.6890.83
123_L129_Q0.6840.83
28_E60_E0.6820.83
64_V100_A0.6790.82
25_L51_I0.6780.82
17_P148_E0.6770.82
62_Y95_D0.6770.82
112_W151_D0.6770.82
138_T142_L0.6760.82
32_K50_D0.6760.82
77_S82_Y0.6740.82
108_C119_E0.6730.82
48_F174_I0.6700.81
110_N125_N0.6680.81
146_R166_Q0.6680.81
88_V172_T0.6670.81
119_E149_I0.6660.81
46_H50_D0.6660.81
39_Q46_H0.6620.81
42_R45_A0.6590.80
159_E162_R0.6590.80
124_V127_A0.6590.80
189_P192_I0.6560.80
116_A121_R0.6530.80
94_F141_V0.6430.79
129_Q143_G0.6400.78
19_D164_S0.6370.78
54_F58_S0.6360.78
123_L127_A0.6350.78
101_A161_I0.6290.77
55_V59_A0.6290.77
39_Q42_R0.6280.77
132_K137_N0.6270.77
37_S189_P0.6240.77
145_R165_I0.6240.77
2_M8_R0.6230.77
33_A47_A0.6190.76
89_A173_Y0.6180.76
59_A100_A0.6160.76
164_S168_V0.6150.76
10_V14_L0.6120.75
17_P21_L0.6120.75
93_T165_I0.6110.75
91_R169_G0.6090.75
32_K42_R0.6060.75
25_L53_A0.5990.74
68_G71_G0.5990.74
14_L119_E0.5980.74
22_R66_L0.5980.74
2_M23_D0.5970.74
177_Y185_Y0.5970.74
74_T83_K0.5960.73
110_N121_R0.5920.73
28_E46_H0.5910.73
120_L124_V0.5910.73
98_L102_K0.5900.73
31_A34_K0.5900.73
126_D143_G0.5890.73
52_A86_V0.5870.72
22_R58_S0.5870.72
54_F66_L0.5870.72
98_L138_T0.5840.72
35_E38_E0.5800.71
105_I161_I0.5800.71
51_I73_V0.5760.71
182_D186_Q0.5760.71
73_V86_V0.5750.71
100_A160_A0.5740.71
19_D97_R0.5740.71
129_Q132_K0.5720.70
123_L147_L0.5720.70
111_E114_E0.5720.70
86_V174_I0.5670.70
76_T80_G0.5660.70
145_R161_I0.5630.69
4_D146_R0.5630.69
82_Y176_F0.5610.69
98_L101_A0.5580.68
2_M24_E0.5510.68
4_D10_V0.5510.68
25_L54_F0.5510.68
110_N126_D0.5470.67
30_V178_E0.5470.67
105_I141_V0.5440.67
109_L125_N0.5410.66
141_V161_I0.5400.66
2_M6_K0.5390.66
56_E60_E0.5390.66
53_A61_E0.5350.65
22_R166_Q0.5300.65
65_K107_E0.5290.64
105_I157_A0.5280.64
122_A148_E0.5250.64
122_A125_N0.5250.64
32_K43_F0.5240.64
34_K37_S0.5210.63
118_P150_D0.5180.63
41_A46_H0.5170.63
29_I51_I0.5110.62
28_E61_E0.5110.62
18_I95_D0.5110.62
15_V27_R0.5100.62
58_S100_A0.5100.62
109_L115_G0.5090.61
30_V33_A0.5090.61
138_T141_V0.5050.61
1_Y6_K0.5050.61
27_R31_A0.5030.61
143_G147_L0.5020.60
52_A73_V0.5010.60
174_I192_I0.5000.60
16_K19_D0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wnyA 1 0.5206 24.4 0.939 Contact Map
4rbnA 3 0.4485 9.9 0.949 Contact Map
1j7nA 2 0.9021 9 0.95 Contact Map
1cl8A 2 0.5 8.7 0.95 Contact Map
1t6sA 4 0.4175 5.4 0.955 Contact Map
2julA 1 0.6289 5 0.956 Contact Map
3zpnA 2 0.2887 4.9 0.956 Contact Map
3o0lA 2 0.2423 4.6 0.956 Contact Map
4d0pA 1 0.8041 4.5 0.957 Contact Map
1pcfA 2 0.201 4.1 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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