GREMLIN Database
DUF3159 - Protein of unknown function (DUF3159)
PFAM: PF11361 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 187 (183)
Sequences: 3837 (2563)
Seq/√Len: 189.5
META: 0.758

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V133_W4.4051.00
67_L71_R3.5901.00
76_E153_G3.4301.00
135_W177_T3.4081.00
90_A140_L3.0251.00
20_V33_A2.7371.00
84_L88_A2.6951.00
138_V173_A2.6651.00
26_G29_P2.3081.00
82_G162_R2.2511.00
28_R32_I2.2271.00
32_I36_A2.1641.00
100_R125_R2.0911.00
92_A95_V2.0801.00
146_Q165_M2.0731.00
27_L31_L2.0711.00
101_R106_V2.0661.00
16_V37_V2.0081.00
97_V136_A1.9721.00
101_R116_T1.9461.00
29_P32_I1.9011.00
97_V129_S1.8761.00
93_F132_T1.8551.00
94_L136_A1.8161.00
147_L151_L1.8031.00
42_A59_L1.8021.00
125_R129_S1.7931.00
20_V30_A1.7061.00
29_P33_A1.7031.00
16_V33_A1.6841.00
87_A143_L1.6841.00
35_L39_V1.6621.00
45_R50_Q1.6471.00
40_V44_V1.6441.00
141_L165_M1.6411.00
143_L147_L1.6301.00
104_V131_A1.5921.00
95_V99_V1.5671.00
20_V29_P1.5561.00
96_S132_T1.5001.00
97_V132_T1.5001.00
36_A40_V1.4941.00
74_S77_D1.4721.00
31_L66_A1.4231.00
154_Q157_A1.4091.00
46_L49_R1.3931.00
91_L95_V1.3921.00
68_I81_P1.3701.00
93_F103_L1.3671.00
133_W136_A1.3331.00
101_R119_R1.3141.00
38_A59_L1.2941.00
134_L180_L1.2911.00
114_E124_L1.2821.00
131_A177_T1.2631.00
5_R9_E1.2611.00
64_I81_P1.2511.00
145_V165_M1.2481.00
90_A136_A1.2411.00
175_A179_W1.2411.00
156_G159_G1.2391.00
82_G146_Q1.2301.00
100_R129_S1.2271.00
67_L70_L1.2071.00
136_A140_L1.1941.00
26_G30_A1.1911.00
126_R130_R1.1821.00
24_T30_A1.1781.00
66_A69_A1.1751.00
33_A36_A1.1701.00
146_Q162_R1.1391.00
96_S99_V1.1311.00
91_L94_L1.1281.00
106_V116_T1.1261.00
149_L157_A1.1221.00
35_L59_L1.1211.00
160_V164_A1.1111.00
133_W137_A1.1041.00
38_A62_V1.0951.00
20_V25_A1.0931.00
63_A67_L1.0841.00
94_L97_V1.0791.00
175_A178_W1.0751.00
127_A131_A1.0741.00
83_I143_L1.0401.00
139_F142_R1.0261.00
60_L64_I1.0221.00
178_W182_R1.0191.00
35_L63_A1.0111.00
176_V180_L1.0061.00
16_V20_V1.0061.00
134_L173_A1.0010.99
104_V177_T0.9890.99
90_A93_F0.9890.99
93_F104_V0.9830.99
57_S65_A0.9810.99
104_V132_T0.9790.99
4_V8_V0.9740.99
90_A94_L0.9730.99
43_V47_V0.9610.99
80_L150_Y0.9590.99
113_G116_T0.9590.99
61_G65_A0.9460.99
171_A175_A0.9430.99
84_L87_A0.9380.99
73_G77_D0.9370.99
55_A58_G0.9350.99
53_Q57_S0.9330.99
103_L106_V0.9310.99
177_T180_L0.9220.99
129_S133_W0.9080.99
148_P151_L0.9030.99
112_R128_Y0.9030.99
149_L161_A0.9010.99
56_L60_L0.8870.99
155_V159_G0.8800.99
86_N142_R0.8750.99
52_L56_L0.8700.99
38_A42_A0.8660.99
31_L70_L0.8640.99
72_T77_D0.8600.98
44_V48_R0.8470.98
157_A164_A0.8410.98
145_V161_A0.8360.98
148_P152_A0.8330.98
77_D81_P0.8320.98
122_P125_R0.8310.98
172_L175_A0.8300.98
73_G76_E0.8280.98
39_V59_L0.8280.98
1_L4_V0.8220.98
42_A56_L0.8220.98
170_T174_L0.8220.98
157_A161_A0.8100.98
162_R165_M0.8060.98
83_I147_L0.8030.98
144_A148_P0.7970.97
157_A160_V0.7920.97
144_A147_L0.7910.97
51_P54_Q0.7870.97
18_V65_A0.7870.97
156_G160_V0.7820.97
12_L37_V0.7800.97
149_L154_Q0.7800.97
21_N24_T0.7780.97
30_A34_A0.7760.97
104_V128_Y0.7710.97
79_F159_G0.7670.97
74_S153_G0.7650.97
81_P85_T0.7620.97
109_G114_E0.7610.97
108_A112_R0.7590.97
11_A14_V0.7580.97
134_L176_V0.7570.97
62_V78_Y0.7520.96
1_L10_S0.7500.96
88_A92_A0.7490.96
8_V12_L0.7300.96
43_V46_L0.7300.96
161_A165_M0.7300.96
106_V110_A0.7270.96
90_A143_L0.7220.96
80_L83_I0.7180.95
159_G163_L0.7160.95
15_L19_V0.7040.95
116_T120_R0.6970.95
143_L148_P0.6970.95
39_V43_V0.6970.95
89_Y93_F0.6840.94
93_F96_S0.6840.94
37_V41_L0.6790.94
170_T177_T0.6760.94
62_V65_A0.6760.94
130_R134_L0.6760.94
57_S60_L0.6720.93
127_A130_R0.6710.93
71_R77_D0.6690.93
135_W170_T0.6690.93
167_W171_A0.6640.93
42_A55_A0.6640.93
60_L63_A0.6640.93
176_V179_W0.6600.93
168_P174_L0.6600.93
85_T89_Y0.6580.93
46_L52_L0.6570.93
105_G119_R0.6550.93
128_Y131_A0.6540.93
179_W183_R0.6520.92
2_G6_G0.6520.92
36_A39_V0.6520.92
1_L5_R0.6490.92
21_N25_A0.6470.92
138_V169_L0.6460.92
121_D124_L0.6450.92
49_R56_L0.6420.92
37_V40_V0.6410.92
41_L44_V0.6400.92
64_I67_L0.6380.92
36_A43_V0.6350.91
21_N155_V0.6340.91
31_L34_A0.6340.91
110_A113_G0.6340.91
165_M168_P0.6320.91
110_A116_T0.6290.91
27_L75_A0.6270.91
7_L11_A0.6230.91
86_N143_L0.6200.90
82_G165_M0.6200.90
102_P132_T0.6180.90
114_E117_A0.6180.90
172_L176_V0.6150.90
62_V66_A0.6150.90
150_Y158_L0.6140.90
132_T135_W0.6110.90
84_L143_L0.6090.90
18_V22_A0.6060.89
44_V47_V0.5970.89
64_I69_A0.5960.89
101_R113_G0.5940.88
94_L98_L0.5930.88
70_L78_Y0.5900.88
11_A41_L0.5900.88
68_I77_D0.5880.88
170_T175_A0.5840.88
53_Q59_L0.5830.88
137_A140_L0.5820.87
108_A128_Y0.5810.87
117_A121_D0.5800.87
21_N30_A0.5780.87
97_V101_R0.5780.87
135_W139_F0.5770.87
83_I150_Y0.5750.87
71_R161_A0.5740.87
83_I151_L0.5710.86
127_A180_L0.5680.86
68_I72_T0.5680.86
20_V24_T0.5630.86
9_E135_W0.5630.86
15_L22_A0.5610.85
19_V24_T0.5600.85
106_V115_P0.5590.85
4_V9_E0.5530.85
34_A62_V0.5530.85
104_V135_W0.5510.84
25_A29_P0.5490.84
83_I87_A0.5490.84
181_L184_A0.5480.84
145_V148_P0.5460.84
5_R8_V0.5450.84
81_P84_L0.5430.84
139_F165_M0.5420.83
122_P126_R0.5420.83
89_Y92_A0.5410.83
14_V18_V0.5400.83
101_R109_G0.5380.83
167_W170_T0.5360.83
95_V136_A0.5350.83
98_L136_A0.5250.82
167_W175_A0.5240.81
165_M169_L0.5240.81
53_Q86_N0.5240.81
106_V119_R0.5220.81
138_V141_L0.5200.81
28_R70_L0.5190.81
70_L74_S0.5150.80
86_N89_Y0.5120.80
45_R49_R0.5090.80
142_R168_P0.5070.79
26_G32_I0.5070.79
173_A181_L0.5050.79
52_L55_A0.5030.79
76_E155_V0.5020.79
175_A183_R0.5010.78
174_L181_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.8556 27.4 0.925 Contact Map
4gc0A 1 0.6738 13.5 0.935 Contact Map
3wdoA 1 0.6524 4.1 0.949 Contact Map
2wswA 3 0.9572 3.9 0.949 Contact Map
2mofA 1 0.1872 3.7 0.95 Contact Map
4pypA 1 0.6471 3.7 0.95 Contact Map
2jlnA 1 0.8342 3.4 0.951 Contact Map
1kf6C 1 0.4439 3.4 0.951 Contact Map
3j45G 1 0.3422 2.7 0.953 Contact Map
4c7rA 3 0.9412 2.6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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