GREMLIN Database
DUF3110 - Protein of unknown function (DUF3110)
PFAM: PF11360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (76)
Sequences: 1873 (1033)
Seq/√Len: 118.4
META: 0.913

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E76_P3.5891.00
62_K66_M3.2821.00
75_T78_D3.1051.00
41_M44_A2.7741.00
24_K27_L2.7171.00
40_M43_E2.5331.00
28_L60_I2.4321.00
32_E36_E2.2011.00
23_E27_L2.1341.00
78_D81_I1.9141.00
57_D61_I1.8811.00
30_E76_P1.8241.00
40_M44_A1.7451.00
36_E40_M1.6201.00
23_E26_V1.5731.00
56_D59_E1.5511.00
61_I71_Y1.5401.00
42_L47_F1.5171.00
30_E75_T1.5121.00
59_E63_T1.4761.00
33_D36_E1.4371.00
41_M81_I1.4011.00
15_A63_T1.3731.00
58_E62_K1.3421.00
23_E70_K1.3251.00
71_Y81_I1.2620.99
11_E51_T1.2090.99
17_S60_I1.1810.99
28_L69_Y1.1490.99
19_Q22_G1.1060.99
59_E62_K1.0770.98
26_V69_Y1.0500.98
28_L73_I1.0130.97
12_D60_I0.9670.97
25_V72_A0.9540.96
61_I65_E0.9520.96
17_S48_P0.9280.96
33_D46_D0.9140.95
29_F35_A0.8950.95
18_V27_L0.8900.95
35_A69_Y0.8860.95
34_D37_R0.8850.94
71_Y78_D0.8670.94
15_A60_I0.8630.94
38_Y78_D0.8550.93
28_L71_Y0.8530.93
38_Y81_I0.8380.93
58_E65_E0.8300.92
14_G17_S0.8220.92
31_E65_E0.8130.92
57_D63_T0.8060.91
9_G12_D0.8030.91
54_E71_Y0.7980.91
47_F70_K0.7930.91
18_V83_P0.7800.90
27_L60_I0.7570.88
28_L62_K0.7550.88
33_D37_R0.7550.88
55_V60_I0.7510.88
10_K13_E0.7480.88
19_Q47_F0.7390.87
18_V80_V0.7350.87
73_I78_D0.7290.86
63_T69_Y0.7120.85
9_G17_S0.7110.85
78_D83_P0.7080.85
45_Q53_I0.7030.84
11_E21_D0.6970.84
35_A52_V0.6950.84
56_D72_A0.6920.84
75_T79_I0.6590.80
9_G48_P0.6580.80
52_V55_V0.6570.80
13_E50_M0.6560.80
28_L57_D0.6480.79
26_V38_Y0.6450.79
8_A60_I0.6360.78
53_I60_I0.6340.78
76_P79_I0.6260.77
56_D78_D0.6200.76
26_V63_T0.6140.76
43_E48_P0.6140.76
18_V77_N0.6130.75
47_F59_E0.6120.75
32_E54_E0.6100.75
26_V71_Y0.6100.75
31_E78_D0.5970.74
51_T56_D0.5910.73
71_Y80_V0.5890.73
53_I59_E0.5890.73
51_T55_V0.5700.70
54_E73_I0.5690.70
15_A26_V0.5660.70
27_L47_F0.5660.70
62_K65_E0.5610.69
16_Y45_Q0.5550.68
37_R41_M0.5500.67
13_E58_E0.5460.67
37_R79_I0.5420.66
32_E49_E0.5400.66
63_T67_H0.5360.65
18_V38_Y0.5310.65
15_A50_M0.5250.64
48_P68_G0.5250.64
16_Y19_Q0.5230.64
53_I67_H0.5230.64
17_S43_E0.5200.63
14_G33_D0.5120.62
58_E75_T0.5120.62
16_Y22_G0.5080.61
30_E58_E0.5060.61
60_I67_H0.5060.61
57_D74_I0.5050.61
9_G15_A0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e6zA 1 0.9524 74.2 0.84 Contact Map
4ev1A 2 0.9524 71.1 0.844 Contact Map
2jyaA 1 0.6429 35.7 0.874 Contact Map
2ljuA 1 0.7024 35.5 0.874 Contact Map
4wkgA 5 0.9524 25.6 0.883 Contact Map
2blnA 1 0.9286 17.1 0.892 Contact Map
4dixA 1 0.6905 14.7 0.896 Contact Map
2hiqA 2 0.5476 14.6 0.896 Contact Map
1tueB 1 0.5238 13.4 0.897 Contact Map
2asyA 2 0.6786 12 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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