GREMLIN Database
DUF3153 - Protein of unknown function (DUF3153)
PFAM: PF11353 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 209 (206)
Sequences: 647 (473)
Seq/√Len: 32.9
META: 0.631

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_D174_H6.2601.00
198_L202_L3.5341.00
22_N141_I3.0481.00
146_A163_L2.8231.00
191_A195_L2.6781.00
80_L84_L2.5561.00
124_D173_N2.3990.99
29_I32_G2.3610.99
70_L73_P2.3180.99
37_S49_F2.3140.99
62_R67_E2.3010.99
64_S67_E2.2900.99
26_D115_V2.2060.99
20_G138_F2.1680.99
63_Q67_E2.1630.99
180_W186_G2.1000.98
26_D183_S2.0260.98
83_K87_F2.0210.98
49_F70_L1.9980.98
128_L169_P1.9890.98
120_R176_E1.9580.98
58_G73_P1.9220.97
183_S186_G1.9020.97
187_I191_A1.8180.96
155_A158_I1.8140.96
204_Y207_L1.8120.96
142_T146_A1.7810.96
136_L173_N1.7640.95
21_L146_A1.7070.94
58_G74_F1.7070.94
116_R140_L1.7040.94
96_G121_L1.6960.94
26_D181_L1.6910.94
47_L50_E1.6720.94
48_S52_R1.6500.93
157_E161_N1.6480.93
139_K162_T1.6130.93
113_L190_L1.5820.92
134_L176_E1.5810.92
143_P165_W1.5770.92
165_W169_P1.5550.91
72_I83_K1.5400.91
23_F179_F1.5250.90
27_D151_G1.5240.90
108_Q117_N1.5220.90
200_Y204_Y1.4970.89
80_L132_S1.4950.89
80_L140_L1.4890.89
185_L188_G1.4830.89
27_D115_V1.4120.86
54_K162_T1.3660.84
78_E82_Q1.3330.83
7_L11_L1.3320.83
195_L202_L1.3240.83
82_Q158_I1.3210.82
167_L170_G1.3100.82
7_L200_Y1.3060.82
32_G189_A1.3040.82
79_E122_D1.3040.82
143_P150_N1.2990.81
3_L12_S1.2980.81
9_L101_N1.2950.81
12_S185_L1.2920.81
69_S78_E1.2890.81
6_L12_S1.2860.81
16_R141_I1.2820.80
4_L197_L1.2800.80
54_K59_K1.2570.79
11_L14_C1.2410.78
15_V128_L1.2360.78
27_D185_L1.2340.78
144_W182_P1.2320.78
18_D52_R1.2290.78
113_L118_R1.2190.77
8_A37_S1.2110.76
45_W180_W1.2070.76
185_L189_A1.1700.74
31_L110_N1.1650.74
62_R65_D1.1570.73
202_L206_R1.1560.73
51_E54_K1.1320.71
16_R135_D1.1310.71
141_I162_T1.1290.71
53_L58_G1.1180.70
26_D114_F1.1120.70
2_L12_S1.1110.70
16_R24_S1.0960.69
50_E57_G1.0930.69
72_I87_F1.0840.68
106_L197_L1.0830.68
115_V183_S1.0760.67
134_L172_V1.0650.67
16_R57_G1.0650.67
200_Y206_R1.0650.67
77_G83_K1.0630.67
125_L170_G1.0630.67
156_L161_N1.0550.66
137_E166_K1.0540.66
58_G182_P1.0510.66
150_N153_P1.0460.65
40_G206_R1.0420.65
180_W192_I1.0360.64
9_L32_G1.0270.64
110_N180_W1.0180.63
116_R121_L1.0170.63
106_L177_A1.0130.63
45_W110_N1.0120.63
77_G81_E1.0110.63
27_D206_R1.0020.62
168_K173_N0.9960.61
69_S72_I0.9940.61
15_V179_F0.9940.61
123_L138_F0.9920.61
72_I80_L0.9760.60
146_A151_G0.9690.59
192_I199_G0.9670.59
68_L74_F0.9660.59
108_Q121_L0.9650.59
133_G141_I0.9580.58
40_G191_A0.9580.58
180_W183_S0.9520.58
11_L175_L0.9500.58
175_L188_G0.9490.58
3_L6_L0.9440.57
52_R56_L0.9420.57
57_G105_S0.9270.56
124_D170_G0.9210.55
141_I195_L0.9180.55
74_F80_L0.9170.55
108_Q114_F0.9130.55
172_V177_A0.9080.54
29_I33_E0.9060.54
15_V45_W0.9040.54
105_S161_N0.9030.54
197_L200_Y0.9000.54
3_L49_F0.8990.54
120_R190_L0.8980.53
31_L36_T0.8840.52
151_G154_S0.8700.51
27_D114_F0.8560.50
4_L113_L0.8520.50
30_Q185_L0.8520.50
112_L187_I0.8510.50
5_L199_G0.8490.49
4_L51_E0.8410.49
14_C165_W0.8330.48
147_T151_G0.8270.48
29_I36_T0.8260.47
150_N154_S0.8240.47
129_G135_D0.8230.47
21_L175_L0.8220.47
59_K126_R0.8210.47
174_H184_P0.8200.47
138_F174_H0.8140.46
49_F110_N0.8090.46
120_R174_H0.8080.46
107_R159_T0.8070.46
151_G175_L0.8060.46
183_S189_A0.8050.46
9_L53_L0.8040.46
9_L20_G0.8030.46
170_G180_W0.8010.45
39_S61_E0.7950.45
78_E149_T0.7940.45
183_S187_I0.7830.44
190_L194_L0.7820.44
22_N70_L0.7810.44
155_A159_T0.7800.44
48_S54_K0.7780.43
151_G156_L0.7780.43
13_G170_G0.7780.43
126_R192_I0.7720.43
146_A149_T0.7700.43
107_R157_E0.7650.42
32_G38_F0.7580.42
52_R175_L0.7550.42
61_E183_S0.7510.41
72_I75_L0.7510.41
72_I84_L0.7450.41
180_W184_P0.7450.41
49_F90_P0.7440.41
42_K54_K0.7420.41
15_V162_T0.7380.40
116_R119_L0.7370.40
138_F144_W0.7300.40
126_R138_F0.7290.40
143_P146_A0.7280.39
17_Y131_L0.7270.39
35_L43_L0.7180.39
118_R159_T0.7180.39
6_L127_S0.7100.38
120_R152_D0.7080.38
120_R157_E0.7080.38
31_L49_F0.7060.38
33_E199_G0.7040.38
190_L201_L0.7030.37
31_L35_L0.7020.37
80_L85_N0.6960.37
196_V202_L0.6950.37
8_A152_D0.6910.37
16_R29_I0.6910.37
114_F185_L0.6890.36
118_R160_K0.6850.36
79_E154_S0.6840.36
82_Q206_R0.6820.36
48_S133_G0.6820.36
75_L191_A0.6810.36
79_E84_L0.6780.36
54_K62_R0.6780.36
178_S197_L0.6700.35
144_W179_F0.6670.35
124_D188_G0.6660.35
82_Q154_S0.6650.35
37_S51_E0.6650.35
129_G132_S0.6620.34
143_P177_A0.6610.34
29_I196_V0.6600.34
45_W128_L0.6590.34
41_K65_D0.6550.34
43_L46_Q0.6530.34
112_L188_G0.6520.34
35_L48_S0.6500.33
150_N158_I0.6490.33
151_G207_L0.6440.33
106_L115_V0.6440.33
189_A195_L0.6410.33
115_V184_P0.6400.33
80_L128_L0.6400.33
129_G137_E0.6380.33
191_A198_L0.6250.32
77_G84_L0.6230.31
62_R113_L0.6200.31
101_N157_E0.6190.31
76_N177_A0.6180.31
163_L175_L0.6130.31
50_E62_R0.6130.31
51_E107_R0.6110.31
72_I79_E0.6070.30
186_G192_I0.6020.30
32_G37_S0.6010.30
12_S161_N0.5980.30
7_L206_R0.5950.30
182_P203_R0.5910.29
45_W49_F0.5890.29
6_L10_L0.5890.29
7_L195_L0.5870.29
64_S68_L0.5860.29
113_L160_K0.5850.29
15_V136_L0.5840.29
17_Y108_Q0.5840.29
8_A105_S0.5830.29
166_K169_P0.5820.29
18_D21_L0.5810.29
116_R178_S0.5780.28
53_L80_L0.5780.28
175_L191_A0.5740.28
16_R119_L0.5730.28
94_L198_L0.5710.28
29_I187_I0.5690.28
146_A176_E0.5690.28
128_L138_F0.5660.28
150_N156_L0.5620.27
11_L125_L0.5590.27
72_I182_P0.5580.27
81_E130_D0.5580.27
5_L123_L0.5570.27
81_E105_S0.5560.27
190_L193_V0.5550.27
154_S158_I0.5550.27
3_L113_L0.5520.27
201_L204_Y0.5510.27
153_P156_L0.5490.26
27_D33_E0.5490.26
157_E206_R0.5480.26
142_T165_W0.5480.26
21_L206_R0.5470.26
195_L198_L0.5450.26
139_K178_S0.5440.26
138_F167_L0.5430.26
69_S73_P0.5420.26
25_G39_S0.5400.26
57_G60_A0.5380.26
66_G106_L0.5370.26
77_G116_R0.5360.26
84_L186_G0.5340.25
115_V134_L0.5340.25
113_L183_S0.5320.25
19_V179_F0.5280.25
70_L198_L0.5250.25
10_L27_D0.5230.25
200_Y205_Y0.5220.25
26_D142_T0.5210.25
17_Y138_F0.5200.25
49_F101_N0.5200.25
136_L146_A0.5190.25
54_K82_Q0.5160.24
97_L127_S0.5160.24
167_L186_G0.5150.24
104_L196_V0.5140.24
11_L162_T0.5120.24
24_S175_L0.5080.24
32_G36_T0.5070.24
30_Q35_L0.5060.24
118_R193_V0.5060.24
63_Q69_S0.5060.24
41_K190_L0.5040.24
135_D166_K0.5020.23
59_K62_R0.5000.23
17_Y87_F0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j6da 3 0.5359 93.9 0.877 Contact Map
2l2tA 2 0.1914 35.9 0.929 Contact Map
2mofA 1 0.177 34.4 0.929 Contact Map
2k1kA 2 0.1818 27.6 0.933 Contact Map
2kluA 1 0.1722 27 0.933 Contact Map
2m20A 2 0.1388 23.5 0.935 Contact Map
2lp1A 1 0.2201 21.7 0.936 Contact Map
2ks1B 1 0.1914 19.6 0.937 Contact Map
3zbiC 1 0.1292 19.1 0.938 Contact Map
2mfrA 1 0.2153 17.6 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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