GREMLIN Database
GTA_holin_3TM - Holin of 3TMs, for gene-transfer release
PFAM: PF11351 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (107)
Sequences: 6770 (4396)
Seq/√Len: 425.0
META: 0.941

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_E57_K3.9331.00
58_A61_A3.5051.00
73_A79_G3.3311.00
47_E50_K3.3121.00
29_E32_K3.1961.00
20_E23_K3.0101.00
70_W75_G2.9971.00
74_I79_G2.2901.00
31_A34_Q2.0831.00
64_S69_G1.9061.00
62_S67_V1.8911.00
77_V83_A1.8461.00
17_D20_E1.7491.00
32_K36_A1.7431.00
73_A76_W1.6731.00
109_T112_G1.5801.00
66_F73_A1.5681.00
18_K21_K1.5381.00
22_A25_K1.5341.00
19_D23_K1.5291.00
64_S68_A1.5241.00
65_W69_G1.4931.00
21_K25_K1.3651.00
51_A54_E1.3121.00
11_L15_I1.3031.00
5_G9_K1.2961.00
84_Y89_Q1.2941.00
9_K12_D1.2321.00
84_Y91_L1.2171.00
18_K22_A1.2051.00
113_G117_L1.2041.00
106_E109_T1.1991.00
13_K16_P1.1891.00
74_I111_L1.1791.00
57_K61_A1.1781.00
95_A99_G1.1451.00
50_K54_E1.1391.00
12_D25_K1.1011.00
101_A104_P1.0941.00
59_E70_W1.0901.00
89_Q93_A1.0871.00
66_F76_W1.0831.00
23_K29_E1.0781.00
19_D22_A1.0741.00
16_P22_A1.0741.00
5_G8_G1.0681.00
20_E24_A1.0671.00
15_I18_K1.0651.00
63_G68_A1.0431.00
7_V10_L1.0191.00
30_L34_Q1.0191.00
85_N89_Q1.0101.00
21_K24_A0.9981.00
62_S65_W0.9951.00
78_C111_L0.9771.00
96_L100_G0.9751.00
108_W112_G0.9631.00
80_A83_A0.9501.00
4_I7_V0.9461.00
114_M117_L0.9351.00
81_A86_F0.9211.00
109_T113_G0.9191.00
63_G67_V0.9181.00
15_I20_E0.9171.00
45_E48_L0.8911.00
66_F69_G0.8901.00
16_P21_K0.8821.00
93_A96_L0.8771.00
45_E49_A0.8721.00
10_L14_F0.8651.00
32_K35_Q0.8621.00
3_L6_P0.8611.00
62_S68_A0.8611.00
15_I24_A0.8571.00
6_P10_L0.8541.00
12_D21_K0.8521.00
65_W68_A0.8511.00
17_D23_K0.8481.00
6_P9_K0.8481.00
30_L33_L0.8441.00
59_E75_G0.8341.00
8_G12_D0.8231.00
84_Y88_L0.8221.00
22_A26_L0.8191.00
101_A105_E0.8131.00
31_A35_Q0.8011.00
16_P19_D0.7951.00
11_L21_K0.7931.00
96_L99_G0.7771.00
64_S67_V0.7711.00
75_G114_M0.7691.00
51_A57_K0.7601.00
94_W98_L0.7601.00
73_A80_A0.7461.00
95_A100_G0.7441.00
106_E112_G0.7201.00
49_A53_L0.7181.00
52_Q55_I0.7171.00
81_A85_N0.7151.00
69_G76_W0.7061.00
44_A48_L0.7061.00
17_D21_K0.7041.00
85_N106_E0.7011.00
74_I78_C0.6981.00
16_P20_E0.6911.00
46_L50_K0.6891.00
53_L57_K0.6871.00
84_Y92_L0.6821.00
69_G73_A0.6751.00
8_G13_K0.6741.00
15_I21_K0.6711.00
23_K26_L0.6540.99
59_E67_V0.6440.99
82_L110_L0.6440.99
48_L52_Q0.6430.99
4_I8_G0.6300.99
15_I19_D0.6250.99
93_A97_A0.6240.99
112_G117_L0.6240.99
11_L14_F0.6190.99
94_W97_A0.6140.99
11_L16_P0.6110.99
85_N109_T0.6100.99
92_L95_A0.6030.99
51_A55_I0.6030.99
35_Q44_A0.6010.99
82_L111_L0.6000.99
56_N60_A0.5930.99
82_L85_N0.5910.99
86_F106_E0.5900.99
30_L36_A0.5800.99
82_L108_W0.5770.99
12_D16_P0.5770.99
81_A84_Y0.5770.99
19_D24_A0.5740.99
89_Q92_L0.5710.99
25_K31_A0.5680.98
86_F110_L0.5680.98
89_Q96_L0.5650.98
29_E34_Q0.5620.98
77_V81_A0.5600.98
54_E58_A0.5590.98
4_I9_K0.5560.98
33_L36_A0.5560.98
92_L96_L0.5550.98
13_K17_D0.5490.98
26_L29_E0.5420.98
91_L94_W0.5410.98
30_L35_Q0.5380.98
80_A84_Y0.5330.98
8_G11_L0.5330.98
82_L107_L0.5330.98
55_I59_E0.5320.98
108_W111_L0.5300.98
19_D26_L0.5200.97
75_G78_C0.5170.97
6_P16_P0.5170.97
16_P23_K0.5090.97
10_L15_I0.5010.97
81_A108_W0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j6rA 1 0.8455 16.4 0.899 Contact Map
4wd8A 3 0.4146 13.5 0.903 Contact Map
3bulA 1 0.9106 10.2 0.908 Contact Map
1mskA 1 0.9106 8.2 0.912 Contact Map
2m8rA 1 0.7805 6.5 0.916 Contact Map
4rdqA 5 0.6016 5.8 0.918 Contact Map
3fewX 1 0.9837 5.4 0.919 Contact Map
2i88A 1 0.9593 5.3 0.92 Contact Map
1rh1A 1 0.9431 5.2 0.92 Contact Map
1a87A 1 0.9919 4.4 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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