GREMLIN Database
DUF3151 - Protein of unknown function (DUF3151)
PFAM: PF11349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (124)
Sequences: 2976 (1465)
Seq/√Len: 131.5
META: 0.826

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_D52_E2.9671.00
94_A97_A2.7041.00
101_A109_A2.6391.00
93_L115_F2.6051.00
100_A105_E2.5831.00
42_E57_A2.5311.00
110_E114_Q2.5241.00
32_A107_D2.4561.00
35_L39_A2.4531.00
27_A36_A2.4301.00
97_A112_C2.2781.00
45_L53_A2.2751.00
41_A57_A2.1821.00
34_S64_G2.1801.00
57_A95_A2.1131.00
82_S122_A1.8751.00
89_F93_L1.8691.00
44_A48_G1.8381.00
42_E91_R1.8181.00
9_E14_A1.7481.00
97_A109_A1.6991.00
79_V119_S1.6841.00
106_T110_E1.6651.00
109_A112_C1.6231.00
16_A29_R1.6231.00
15_A19_A1.5941.00
97_A113_A1.5911.00
41_A95_A1.5901.00
33_S36_A1.5901.00
50_D102_A1.5281.00
113_A117_R1.5161.00
82_S120_D1.5141.00
114_Q118_D1.4781.00
20_G23_P1.4551.00
81_W87_R1.4441.00
10_D33_S1.3541.00
28_A50_D1.3041.00
42_E45_L1.2681.00
84_E87_R1.2671.00
97_A101_A1.2471.00
94_A98_R1.2241.00
27_A56_Y1.2171.00
21_A25_E1.1860.99
1_G4_P1.1820.99
42_E53_A1.1790.99
16_A30_H1.1740.99
39_A43_L1.1660.99
2_P76_S1.1630.99
14_A18_A1.1380.99
45_L50_D1.1350.99
22_D25_E1.1320.99
32_A70_R1.1290.99
52_E56_Y1.1230.99
24_A49_D1.1100.99
34_S67_A1.1060.99
112_C116_L1.1060.99
67_A71_N1.0830.99
13_A33_S1.0820.99
60_G92_A1.0760.99
39_A42_E1.0580.99
50_D53_A1.0480.99
25_E29_R1.0370.98
117_R124_A1.0360.98
13_A26_V1.0340.98
23_P43_L1.0320.98
17_L20_G1.0170.98
44_A53_A1.0030.98
42_E95_A1.0020.98
22_D43_L0.9870.98
95_A98_R0.9730.98
38_A91_R0.9720.98
12_E15_A0.9670.98
98_R102_A0.9670.98
106_T109_A0.9630.98
120_D124_A0.9580.97
1_G6_L0.9570.97
109_A113_A0.9550.97
64_G79_V0.9480.97
47_A52_E0.9240.97
67_A70_R0.9230.97
33_S39_A0.9100.97
16_A21_A0.9080.96
43_L47_A0.9050.96
10_D13_A0.9020.96
27_A59_V0.8950.96
89_F112_C0.8450.95
14_A33_S0.8320.94
52_E59_V0.8320.94
44_A52_E0.8310.94
91_R95_A0.8220.94
28_A51_V0.8120.93
8_P67_A0.8060.93
42_E98_R0.7830.92
19_A23_P0.7760.92
30_H34_S0.7740.92
8_P71_N0.7700.92
26_V36_A0.7560.91
30_H33_S0.7530.91
16_A20_G0.7510.91
32_A36_A0.7330.89
9_E85_P0.7290.89
38_A60_G0.7280.89
53_A59_V0.7220.89
71_N76_S0.7220.89
16_A19_A0.7170.88
117_R120_D0.7140.88
15_A18_A0.7100.88
121_P124_A0.7080.88
95_A99_A0.7020.87
93_L112_C0.6980.87
39_A92_A0.6930.87
3_P6_L0.6880.86
45_L48_G0.6800.86
94_A122_A0.6750.85
98_R101_A0.6710.85
21_A24_A0.6640.84
52_E67_A0.6640.84
120_D123_A0.6570.84
45_L95_A0.6520.83
51_V59_V0.6510.83
16_A26_V0.6470.83
20_G24_A0.6460.83
94_A123_A0.6410.82
117_R123_A0.6380.82
115_F119_S0.6330.81
11_P15_A0.6290.81
35_L91_R0.6270.81
94_A117_R0.6240.80
64_G67_A0.6240.80
74_K92_A0.6180.80
24_A43_L0.6140.79
18_A84_E0.6130.79
68_L79_V0.6120.79
38_A92_A0.6060.79
99_A102_A0.5990.78
101_A113_A0.5960.77
14_A35_L0.5950.77
6_L9_E0.5930.77
53_A99_A0.5900.77
62_H66_D0.5900.77
58_R65_L0.5860.76
114_Q117_R0.5800.75
113_A122_A0.5790.75
62_H69_R0.5760.75
53_A98_R0.5750.75
78_P83_H0.5750.75
6_L85_P0.5740.75
41_A56_Y0.5720.74
70_R80_P0.5680.74
18_A26_V0.5670.74
9_E15_A0.5670.74
3_P76_S0.5670.74
117_R122_A0.5600.73
40_L51_V0.5570.73
74_K103_I0.5550.72
34_S92_A0.5540.72
76_S115_F0.5500.72
8_P11_P0.5490.71
28_A36_A0.5490.71
45_L98_R0.5460.71
58_R61_Y0.5460.71
27_A51_V0.5450.71
38_A88_G0.5430.71
14_A17_L0.5360.70
33_S38_A0.5330.69
61_Y66_D0.5310.69
31_P103_I0.5310.69
46_A49_D0.5300.69
25_E28_A0.5270.68
64_G92_A0.5260.68
11_P81_W0.5220.68
53_A95_A0.5220.68
82_S87_R0.5210.67
70_R74_K0.5200.67
92_A95_A0.5200.67
83_H99_A0.5180.67
21_A29_R0.5160.67
28_A40_L0.5140.66
76_S79_V0.5120.66
87_R91_R0.5080.66
11_P14_A0.5080.66
58_R66_D0.5080.66
119_S122_A0.5060.65
61_Y69_R0.5020.65
56_Y59_V0.5010.64
70_R78_P0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ja7A 1 0.776 77.8 0.915 Contact Map
2wb0X 1 0.76 74.1 0.918 Contact Map
4i2zA 1 0.624 67.5 0.922 Contact Map
2vsyA 1 0.736 63.5 0.924 Contact Map
4gywA 2 0.768 60.4 0.925 Contact Map
4l9pA 1 0.952 60.4 0.925 Contact Map
3ma5A 1 0.576 58.1 0.926 Contact Map
3beeA 1 0.592 57.8 0.926 Contact Map
2y4tA 1 0.736 55.9 0.927 Contact Map
2pziA 1 0.776 55.8 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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