GREMLIN Database
DUF3150 - Protein of unknown function (DUF3150)
PFAM: PF11348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 256 (254)
Sequences: 766 (668)
Seq/√Len: 41.9
META: 0.811

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_R227_D5.8391.00
102_D137_R5.0251.00
60_R96_E4.4171.00
57_L93_I3.9481.00
36_D119_H3.5841.00
78_V86_V3.4411.00
113_E127_R3.2071.00
167_G170_G3.1891.00
116_I127_R3.0441.00
24_D43_K2.9591.00
89_E92_E2.9311.00
9_L61_A2.8511.00
20_L40_L2.7981.00
64_L86_V2.7591.00
109_D133_A2.7331.00
50_A107_N2.6791.00
101_K137_R2.6331.00
234_P237_G2.6011.00
17_R42_S2.5461.00
226_I250_L2.4261.00
107_N111_A2.2911.00
65_L86_V2.2541.00
24_D40_L2.2451.00
206_R223_V2.2311.00
86_V90_L2.1480.99
80_E148_R2.1190.99
223_V227_D2.0560.99
101_K140_F2.0100.99
94_K98_E1.9210.99
64_L89_E1.8870.99
241_G244_L1.8840.99
100_A103_E1.8530.98
84_D88_A1.8180.98
64_L93_I1.7350.98
91_D144_W1.7230.97
123_E127_R1.6950.97
196_Q237_G1.6840.97
17_R39_S1.6780.97
82_K85_E1.6740.97
227_D231_A1.6730.97
54_F57_L1.6530.97
59_K62_R1.6500.97
9_L19_K1.6360.96
34_P122_W1.6280.96
24_D41_G1.6260.96
132_S135_Y1.6130.96
36_D118_K1.5830.96
239_I244_L1.5410.95
61_A94_K1.5360.95
69_G78_V1.5340.95
116_I126_I1.5200.95
47_D111_A1.4840.94
120_P123_E1.4820.94
200_S204_R1.4810.94
91_D94_K1.4740.94
70_V172_L1.4690.94
197_K201_P1.4620.93
61_A93_I1.4580.93
53_P100_A1.4550.93
110_Q114_E1.4540.93
248_Q251_V1.4260.93
13_I97_F1.4160.92
193_K240_E1.3710.91
209_L219_V1.3620.91
107_N110_Q1.3540.90
79_P211_G1.3490.90
135_Y139_R1.3420.90
240_E243_D1.3330.90
14_W136_V1.3330.90
171_Q175_E1.3310.90
196_Q203_R1.3290.90
206_R226_I1.3260.90
34_P37_L1.3240.89
229_V250_L1.2850.88
124_D128_A1.2810.88
245_L250_L1.2680.87
175_E208_K1.2470.86
210_D227_D1.2450.86
242_A246_A1.2280.86
58_K62_R1.2070.85
54_F58_K1.1980.84
19_K39_S1.1980.84
104_F108_Y1.1730.83
182_E185_E1.1720.83
232_S246_A1.1720.83
104_F140_F1.1700.83
116_I123_E1.1630.82
233_L243_D1.1580.82
65_L76_Y1.1470.81
179_E204_R1.1450.81
188_F198_A1.1420.81
45_L104_F1.1320.81
83_A87_A1.1170.80
24_D33_P1.1160.80
40_L43_K1.1120.79
7_V83_A1.1090.79
223_V226_I1.1050.79
14_W45_L1.0690.77
220_A224_D1.0630.76
90_L144_W1.0510.75
172_L180_A1.0430.75
180_A188_F1.0430.75
11_I58_K1.0370.74
216_D222_L1.0310.74
61_A97_F1.0240.73
59_K63_R1.0190.73
95_A99_A1.0140.73
20_L25_L1.0080.72
54_F104_F1.0050.72
47_D50_A1.0020.72
9_L17_R0.9890.71
191_K195_T0.9880.71
45_L131_P0.9860.70
66_L70_V0.9840.70
87_A91_D0.9800.70
51_L214_F0.9770.70
245_L251_V0.9770.70
224_D235_K0.9750.70
114_E127_R0.9730.69
246_A249_G0.9720.69
13_I136_V0.9710.69
245_L252_L0.9620.69
187_S190_G0.9610.69
65_L90_L0.9600.68
88_A92_E0.9600.68
149_I186_K0.9600.68
119_H126_I0.9540.68
248_Q252_L0.9500.68
4_L77_A0.9470.67
16_G19_K0.9450.67
61_A142_F0.9400.67
85_E106_A0.9290.66
218_R222_L0.9260.66
7_V12_S0.9180.65
48_P115_W0.9160.65
11_I15_S0.9110.64
14_W147_F0.9110.64
14_W108_Y0.9100.64
247_L253_L0.9020.64
12_S141_S0.9000.63
16_G63_R0.8890.62
60_R66_L0.8790.62
244_L251_V0.8750.61
197_K209_L0.8720.61
112_V130_V0.8690.61
62_R76_Y0.8680.61
54_F140_F0.8680.61
50_A114_E0.8680.61
54_F69_G0.8590.60
232_S242_A0.8580.60
176_I187_S0.8570.60
43_K129_A0.8540.59
34_P115_W0.8470.59
243_D246_A0.8460.59
220_A223_V0.8450.58
13_I58_K0.8430.58
104_F115_W0.8430.58
42_S58_K0.8390.58
126_I239_I0.8390.58
250_L255_S0.8380.58
79_P214_F0.8310.57
5_V80_E0.8290.57
15_S76_Y0.8260.57
5_V83_A0.8240.57
245_L249_G0.8190.56
233_L237_G0.8190.56
46_I111_A0.8170.56
94_K97_F0.8170.56
65_L77_A0.8140.56
64_L116_I0.8130.56
109_D113_E0.8120.55
245_L248_Q0.8120.55
230_L252_L0.8110.55
105_L197_K0.8100.55
122_W217_P0.8070.55
72_F77_A0.8040.55
37_L122_W0.8000.54
244_L248_Q0.7980.54
54_F108_Y0.7980.54
50_A111_A0.7980.54
13_I38_A0.7930.54
194_V244_L0.7920.54
15_S45_L0.7920.54
66_L76_Y0.7900.53
33_P37_L0.7870.53
198_A201_P0.7850.53
95_A98_E0.7830.53
46_I50_A0.7830.53
194_V201_P0.7760.52
138_S183_L0.7750.52
32_L38_A0.7700.52
133_A204_R0.7680.51
211_G223_V0.7650.51
183_L198_A0.7650.51
22_P40_L0.7620.51
75_G142_F0.7500.50
17_R61_A0.7480.49
165_V241_G0.7470.49
226_I234_P0.7460.49
21_R24_D0.7430.49
175_E183_L0.7400.49
18_K131_P0.7400.49
105_L137_R0.7380.48
248_Q253_L0.7370.48
131_P245_L0.7360.48
176_I205_I0.7320.48
221_P227_D0.7310.48
235_K242_A0.7310.48
64_L68_V0.7290.48
63_R176_I0.7280.48
6_L10_D0.7230.47
179_E183_L0.7220.47
93_I96_E0.7200.47
16_G51_L0.7180.47
115_W119_H0.7160.46
11_I97_F0.7110.46
140_F215_L0.7100.46
4_L54_F0.7060.46
85_E89_E0.7060.46
202_L214_F0.7050.45
111_A114_E0.7050.45
228_D251_V0.7040.45
79_P108_Y0.7030.45
247_L254_L0.7030.45
168_L222_L0.7020.45
246_A252_L0.6990.45
116_I120_P0.6990.45
252_L255_S0.6950.44
37_L40_L0.6900.44
215_L227_D0.6890.44
12_S56_T0.6880.44
42_S136_V0.6870.44
172_L215_L0.6860.44
75_G129_A0.6860.44
182_E186_K0.6810.43
200_S205_I0.6800.43
18_K207_D0.6790.43
88_A102_D0.6770.43
49_E52_K0.6760.43
4_L170_G0.6760.43
161_L164_E0.6730.42
8_N76_Y0.6730.42
9_L33_P0.6680.42
46_I54_F0.6660.42
15_S25_L0.6650.42
98_E134_E0.6640.42
176_I181_R0.6620.41
209_L226_I0.6580.41
34_P114_E0.6580.41
33_P41_G0.6580.41
228_D231_A0.6580.41
24_D147_F0.6560.41
175_E212_L0.6530.41
165_V183_L0.6500.40
56_T60_R0.6460.40
180_A183_L0.6460.40
67_R101_K0.6450.40
53_P57_L0.6440.40
50_A53_P0.6400.39
198_A217_P0.6400.39
228_D232_S0.6390.39
233_L238_P0.6390.39
85_E88_A0.6390.39
17_R20_L0.6380.39
174_E180_A0.6380.39
41_G147_F0.6370.39
41_G48_P0.6360.39
150_A153_E0.6350.39
73_L77_A0.6340.39
31_E82_K0.6300.39
90_L93_I0.6280.38
220_A243_D0.6280.38
101_K105_L0.6220.38
171_Q174_E0.6200.38
33_P40_L0.6190.38
240_E244_L0.6180.38
51_L54_F0.6170.37
117_A123_E0.6170.37
2_D205_I0.6150.37
109_D228_D0.6150.37
240_E252_L0.6150.37
20_L38_A0.6140.37
51_L156_E0.6080.37
148_R231_A0.6060.36
2_D10_D0.6050.36
137_R222_L0.6030.36
99_A163_E0.6030.36
72_F115_W0.6000.36
243_D247_L0.6000.36
249_G253_L0.6000.36
159_E162_E0.5980.36
6_L78_V0.5980.36
118_K136_V0.5960.36
193_K238_P0.5960.36
144_W164_E0.5940.35
47_D115_W0.5930.35
226_I229_V0.5930.35
173_F177_A0.5920.35
61_A64_L0.5900.35
71_R116_I0.5870.35
15_S58_K0.5810.34
97_F101_K0.5810.34
40_L115_W0.5800.34
147_F196_Q0.5800.34
168_L176_I0.5780.34
173_F218_R0.5720.34
248_Q255_S0.5710.33
5_V8_N0.5680.33
172_L199_L0.5670.33
12_S93_I0.5670.33
225_L255_S0.5640.33
95_A158_D0.5640.33
30_G116_I0.5630.33
143_D160_G0.5610.33
174_E178_Q0.5600.33
89_E99_A0.5600.33
68_V86_V0.5580.32
212_L216_D0.5560.32
169_G173_F0.5560.32
195_T199_L0.5560.32
249_G252_L0.5550.32
27_L40_L0.5550.32
123_E126_I0.5540.32
100_A152_P0.5540.32
50_A104_F0.5530.32
91_D164_E0.5510.32
10_D19_K0.5490.32
26_G152_P0.5490.32
181_R187_S0.5490.32
14_W43_K0.5480.32
231_A243_D0.5470.31
11_I184_W0.5470.31
60_R93_I0.5460.31
202_L230_L0.5440.31
14_W104_F0.5400.31
54_F212_L0.5400.31
65_L144_W0.5380.31
210_D223_V0.5380.31
93_I199_L0.5370.31
131_P135_Y0.5370.31
123_E208_K0.5360.31
201_P244_L0.5340.30
139_R186_K0.5330.30
92_E96_E0.5330.30
246_A251_V0.5320.30
179_E205_I0.5310.30
198_A222_L0.5300.30
224_D242_A0.5290.30
169_G187_S0.5290.30
184_W248_Q0.5280.30
199_L219_V0.5250.30
21_R39_S0.5250.30
57_L97_F0.5240.30
53_P56_T0.5240.30
6_L76_Y0.5240.30
24_D27_L0.5230.30
20_L24_D0.5190.29
221_P230_L0.5180.29
69_G80_E0.5180.29
74_G77_A0.5160.29
106_A159_E0.5150.29
37_L115_W0.5150.29
97_F104_F0.5150.29
77_A101_K0.5120.29
86_V89_E0.5090.28
97_F100_A0.5090.28
43_K72_F0.5080.28
104_F136_V0.5070.28
36_D143_D0.5070.28
111_A115_W0.5070.28
14_W17_R0.5070.28
239_I243_D0.5060.28
7_V78_V0.5060.28
176_I179_E0.5060.28
11_I99_A0.5040.28
30_G84_D0.5020.28
38_A194_V0.5010.28
38_A115_W0.5010.28
25_L90_L0.5010.28
191_K197_K0.5010.28
105_L133_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rj1A 2 0.207 13.2 0.95 Contact Map
4gwpA 1 0.2109 10 0.953 Contact Map
2lemA 1 0.7773 9.8 0.953 Contact Map
3ghgA 2 0.5547 9.4 0.953 Contact Map
2xppA 1 0.3359 9.2 0.954 Contact Map
3iykA 3 0.5781 8.9 0.954 Contact Map
2zxxA 2 0.3047 8.7 0.954 Contact Map
3byiA 4 0.4727 8 0.955 Contact Map
1y6uA 1 0.207 6.3 0.957 Contact Map
3r84A 2 0.2109 6.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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