DUF3150 - PFAM28P - GREMLIN Contacts

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DUF3150 - Protein of unknown function (DUF3150)

PFAM:	PF11348	Sequences: LDKLVLVNLDISIWSGRKKLRPEDLGLGDGELPPEDLASLGSKRLIDPEALKPFNTLKKRARRLLLRVGVRFLGGYAVPEDKADEVAAELDEIKAEFEAAKDEFLANYDQAVEEWIAKHPEWEDIIRAAVPSAEYVRSRFSFDWQVFRIAPPEDDEEDEGLEEEVEGLGGQLFEEIAQEARELWEKSFAGKDKVTQKALSPLRRIRDKLDGLSFLDPRVAPLVDLIDDVLASLPKKGPIEGADLLALQGLVLLLSD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	256 (254)
Sequences:	766 (668)
Seq/√Len:	41.9
META:	0.811

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
206_R	227_D	5.839	1.00
102_D	137_R	5.025	1.00
60_R	96_E	4.417	1.00
57_L	93_I	3.948	1.00
36_D	119_H	3.584	1.00
78_V	86_V	3.441	1.00
113_E	127_R	3.207	1.00
167_G	170_G	3.189	1.00
116_I	127_R	3.044	1.00
24_D	43_K	2.959	1.00
89_E	92_E	2.931	1.00
9_L	61_A	2.851	1.00
20_L	40_L	2.798	1.00
64_L	86_V	2.759	1.00
109_D	133_A	2.733	1.00
50_A	107_N	2.679	1.00
101_K	137_R	2.633	1.00
234_P	237_G	2.601	1.00
17_R	42_S	2.546	1.00
226_I	250_L	2.426	1.00
107_N	111_A	2.291	1.00
65_L	86_V	2.254	1.00
24_D	40_L	2.245	1.00
206_R	223_V	2.231	1.00
86_V	90_L	2.148	0.99
80_E	148_R	2.119	0.99
223_V	227_D	2.056	0.99
101_K	140_F	2.010	0.99
94_K	98_E	1.921	0.99
64_L	89_E	1.887	0.99
241_G	244_L	1.884	0.99
100_A	103_E	1.853	0.98
84_D	88_A	1.818	0.98
64_L	93_I	1.735	0.98
91_D	144_W	1.723	0.97
123_E	127_R	1.695	0.97
196_Q	237_G	1.684	0.97
17_R	39_S	1.678	0.97
82_K	85_E	1.674	0.97
227_D	231_A	1.673	0.97
54_F	57_L	1.653	0.97
59_K	62_R	1.650	0.97
9_L	19_K	1.636	0.96
34_P	122_W	1.628	0.96
24_D	41_G	1.626	0.96
132_S	135_Y	1.613	0.96
36_D	118_K	1.583	0.96
239_I	244_L	1.541	0.95
61_A	94_K	1.536	0.95
69_G	78_V	1.534	0.95
116_I	126_I	1.520	0.95
47_D	111_A	1.484	0.94
120_P	123_E	1.482	0.94
200_S	204_R	1.481	0.94
91_D	94_K	1.474	0.94
70_V	172_L	1.469	0.94
197_K	201_P	1.462	0.93
61_A	93_I	1.458	0.93
53_P	100_A	1.455	0.93
110_Q	114_E	1.454	0.93
248_Q	251_V	1.426	0.93
13_I	97_F	1.416	0.92
193_K	240_E	1.371	0.91
209_L	219_V	1.362	0.91
107_N	110_Q	1.354	0.90
79_P	211_G	1.349	0.90
135_Y	139_R	1.342	0.90
240_E	243_D	1.333	0.90
14_W	136_V	1.333	0.90
171_Q	175_E	1.331	0.90
196_Q	203_R	1.329	0.90
206_R	226_I	1.326	0.90
34_P	37_L	1.324	0.89
229_V	250_L	1.285	0.88
124_D	128_A	1.281	0.88
245_L	250_L	1.268	0.87
175_E	208_K	1.247	0.86
210_D	227_D	1.245	0.86
242_A	246_A	1.228	0.86
58_K	62_R	1.207	0.85
54_F	58_K	1.198	0.84
19_K	39_S	1.198	0.84
104_F	108_Y	1.173	0.83
182_E	185_E	1.172	0.83
232_S	246_A	1.172	0.83
104_F	140_F	1.170	0.83
116_I	123_E	1.163	0.82
233_L	243_D	1.158	0.82
65_L	76_Y	1.147	0.81
179_E	204_R	1.145	0.81
188_F	198_A	1.142	0.81
45_L	104_F	1.132	0.81
83_A	87_A	1.117	0.80
24_D	33_P	1.116	0.80
40_L	43_K	1.112	0.79
7_V	83_A	1.109	0.79
223_V	226_I	1.105	0.79
14_W	45_L	1.069	0.77
220_A	224_D	1.063	0.76
90_L	144_W	1.051	0.75
172_L	180_A	1.043	0.75
180_A	188_F	1.043	0.75
11_I	58_K	1.037	0.74
216_D	222_L	1.031	0.74
61_A	97_F	1.024	0.73
59_K	63_R	1.019	0.73
95_A	99_A	1.014	0.73
20_L	25_L	1.008	0.72
54_F	104_F	1.005	0.72
47_D	50_A	1.002	0.72
9_L	17_R	0.989	0.71
191_K	195_T	0.988	0.71
45_L	131_P	0.986	0.70
66_L	70_V	0.984	0.70
87_A	91_D	0.980	0.70
51_L	214_F	0.977	0.70
245_L	251_V	0.977	0.70
224_D	235_K	0.975	0.70
114_E	127_R	0.973	0.69
246_A	249_G	0.972	0.69
13_I	136_V	0.971	0.69
245_L	252_L	0.962	0.69
187_S	190_G	0.961	0.69
65_L	90_L	0.960	0.68
88_A	92_E	0.960	0.68
149_I	186_K	0.960	0.68
119_H	126_I	0.954	0.68
248_Q	252_L	0.950	0.68
4_L	77_A	0.947	0.67
16_G	19_K	0.945	0.67
61_A	142_F	0.940	0.67
85_E	106_A	0.929	0.66
218_R	222_L	0.926	0.66
7_V	12_S	0.918	0.65
48_P	115_W	0.916	0.65
11_I	15_S	0.911	0.64
14_W	147_F	0.911	0.64
14_W	108_Y	0.910	0.64
247_L	253_L	0.902	0.64
12_S	141_S	0.900	0.63
16_G	63_R	0.889	0.62
60_R	66_L	0.879	0.62
244_L	251_V	0.875	0.61
197_K	209_L	0.872	0.61
112_V	130_V	0.869	0.61
62_R	76_Y	0.868	0.61
54_F	140_F	0.868	0.61
50_A	114_E	0.868	0.61
54_F	69_G	0.859	0.60
232_S	242_A	0.858	0.60
176_I	187_S	0.857	0.60
43_K	129_A	0.854	0.59
34_P	115_W	0.847	0.59
243_D	246_A	0.846	0.59
220_A	223_V	0.845	0.58
13_I	58_K	0.843	0.58
104_F	115_W	0.843	0.58
42_S	58_K	0.839	0.58
126_I	239_I	0.839	0.58
250_L	255_S	0.838	0.58
79_P	214_F	0.831	0.57
5_V	80_E	0.829	0.57
15_S	76_Y	0.826	0.57
5_V	83_A	0.824	0.57
245_L	249_G	0.819	0.56
233_L	237_G	0.819	0.56
46_I	111_A	0.817	0.56
94_K	97_F	0.817	0.56
65_L	77_A	0.814	0.56
64_L	116_I	0.813	0.56
109_D	113_E	0.812	0.55
245_L	248_Q	0.812	0.55
230_L	252_L	0.811	0.55
105_L	197_K	0.810	0.55
122_W	217_P	0.807	0.55
72_F	77_A	0.804	0.55
37_L	122_W	0.800	0.54
244_L	248_Q	0.798	0.54
54_F	108_Y	0.798	0.54
50_A	111_A	0.798	0.54
13_I	38_A	0.793	0.54
194_V	244_L	0.792	0.54
15_S	45_L	0.792	0.54
66_L	76_Y	0.790	0.53
33_P	37_L	0.787	0.53
198_A	201_P	0.785	0.53
95_A	98_E	0.783	0.53
46_I	50_A	0.783	0.53
194_V	201_P	0.776	0.52
138_S	183_L	0.775	0.52
32_L	38_A	0.770	0.52
133_A	204_R	0.768	0.51
211_G	223_V	0.765	0.51
183_L	198_A	0.765	0.51
22_P	40_L	0.762	0.51
75_G	142_F	0.750	0.50
17_R	61_A	0.748	0.49
165_V	241_G	0.747	0.49
226_I	234_P	0.746	0.49
21_R	24_D	0.743	0.49
175_E	183_L	0.740	0.49
18_K	131_P	0.740	0.49
105_L	137_R	0.738	0.48
248_Q	253_L	0.737	0.48
131_P	245_L	0.736	0.48
176_I	205_I	0.732	0.48
221_P	227_D	0.731	0.48
235_K	242_A	0.731	0.48
64_L	68_V	0.729	0.48
63_R	176_I	0.728	0.48
6_L	10_D	0.723	0.47
179_E	183_L	0.722	0.47
93_I	96_E	0.720	0.47
16_G	51_L	0.718	0.47
115_W	119_H	0.716	0.46
11_I	97_F	0.711	0.46
140_F	215_L	0.710	0.46
4_L	54_F	0.706	0.46
85_E	89_E	0.706	0.46
202_L	214_F	0.705	0.45
111_A	114_E	0.705	0.45
228_D	251_V	0.704	0.45
79_P	108_Y	0.703	0.45
247_L	254_L	0.703	0.45
168_L	222_L	0.702	0.45
246_A	252_L	0.699	0.45
116_I	120_P	0.699	0.45
252_L	255_S	0.695	0.44
37_L	40_L	0.690	0.44
215_L	227_D	0.689	0.44
12_S	56_T	0.688	0.44
42_S	136_V	0.687	0.44
172_L	215_L	0.686	0.44
75_G	129_A	0.686	0.44
182_E	186_K	0.681	0.43
200_S	205_I	0.680	0.43
18_K	207_D	0.679	0.43
88_A	102_D	0.677	0.43
49_E	52_K	0.676	0.43
4_L	170_G	0.676	0.43
161_L	164_E	0.673	0.42
8_N	76_Y	0.673	0.42
9_L	33_P	0.668	0.42
46_I	54_F	0.666	0.42
15_S	25_L	0.665	0.42
98_E	134_E	0.664	0.42
176_I	181_R	0.662	0.41
209_L	226_I	0.658	0.41
34_P	114_E	0.658	0.41
33_P	41_G	0.658	0.41
228_D	231_A	0.658	0.41
24_D	147_F	0.656	0.41
175_E	212_L	0.653	0.41
165_V	183_L	0.650	0.40
56_T	60_R	0.646	0.40
180_A	183_L	0.646	0.40
67_R	101_K	0.645	0.40
53_P	57_L	0.644	0.40
50_A	53_P	0.640	0.39
198_A	217_P	0.640	0.39
228_D	232_S	0.639	0.39
233_L	238_P	0.639	0.39
85_E	88_A	0.639	0.39
17_R	20_L	0.638	0.39
174_E	180_A	0.638	0.39
41_G	147_F	0.637	0.39
41_G	48_P	0.636	0.39
150_A	153_E	0.635	0.39
73_L	77_A	0.634	0.39
31_E	82_K	0.630	0.39
90_L	93_I	0.628	0.38
220_A	243_D	0.628	0.38
101_K	105_L	0.622	0.38
171_Q	174_E	0.620	0.38
33_P	40_L	0.619	0.38
240_E	244_L	0.618	0.38
51_L	54_F	0.617	0.37
117_A	123_E	0.617	0.37
2_D	205_I	0.615	0.37
109_D	228_D	0.615	0.37
240_E	252_L	0.615	0.37
20_L	38_A	0.614	0.37
51_L	156_E	0.608	0.37
148_R	231_A	0.606	0.36
2_D	10_D	0.605	0.36
137_R	222_L	0.603	0.36
99_A	163_E	0.603	0.36
72_F	115_W	0.600	0.36
243_D	247_L	0.600	0.36
249_G	253_L	0.600	0.36
159_E	162_E	0.598	0.36
6_L	78_V	0.598	0.36
118_K	136_V	0.596	0.36
193_K	238_P	0.596	0.36
144_W	164_E	0.594	0.35
47_D	115_W	0.593	0.35
226_I	229_V	0.593	0.35
173_F	177_A	0.592	0.35
61_A	64_L	0.590	0.35
71_R	116_I	0.587	0.35
15_S	58_K	0.581	0.34
97_F	101_K	0.581	0.34
40_L	115_W	0.580	0.34
147_F	196_Q	0.580	0.34
168_L	176_I	0.578	0.34
173_F	218_R	0.572	0.34
248_Q	255_S	0.571	0.33
5_V	8_N	0.568	0.33
172_L	199_L	0.567	0.33
12_S	93_I	0.567	0.33
225_L	255_S	0.564	0.33
95_A	158_D	0.564	0.33
30_G	116_I	0.563	0.33
143_D	160_G	0.561	0.33
174_E	178_Q	0.560	0.33
89_E	99_A	0.560	0.33
68_V	86_V	0.558	0.32
212_L	216_D	0.556	0.32
169_G	173_F	0.556	0.32
195_T	199_L	0.556	0.32
249_G	252_L	0.555	0.32
27_L	40_L	0.555	0.32
123_E	126_I	0.554	0.32
100_A	152_P	0.554	0.32
50_A	104_F	0.553	0.32
91_D	164_E	0.551	0.32
10_D	19_K	0.549	0.32
26_G	152_P	0.549	0.32
181_R	187_S	0.549	0.32
14_W	43_K	0.548	0.32
231_A	243_D	0.547	0.31
11_I	184_W	0.547	0.31
60_R	93_I	0.546	0.31
202_L	230_L	0.544	0.31
14_W	104_F	0.540	0.31
54_F	212_L	0.540	0.31
65_L	144_W	0.538	0.31
210_D	223_V	0.538	0.31
93_I	199_L	0.537	0.31
131_P	135_Y	0.537	0.31
123_E	208_K	0.536	0.31
201_P	244_L	0.534	0.30
139_R	186_K	0.533	0.30
92_E	96_E	0.533	0.30
246_A	251_V	0.532	0.30
179_E	205_I	0.531	0.30
198_A	222_L	0.530	0.30
224_D	242_A	0.529	0.30
169_G	187_S	0.529	0.30
184_W	248_Q	0.528	0.30
199_L	219_V	0.525	0.30
21_R	39_S	0.525	0.30
57_L	97_F	0.524	0.30
53_P	56_T	0.524	0.30
6_L	76_Y	0.524	0.30
24_D	27_L	0.523	0.30
20_L	24_D	0.519	0.29
221_P	230_L	0.518	0.29
69_G	80_E	0.518	0.29
74_G	77_A	0.516	0.29
106_A	159_E	0.515	0.29
37_L	115_W	0.515	0.29
97_F	104_F	0.515	0.29
77_A	101_K	0.512	0.29
86_V	89_E	0.509	0.28
97_F	100_A	0.509	0.28
43_K	72_F	0.508	0.28
104_F	136_V	0.507	0.28
36_D	143_D	0.507	0.28
111_A	115_W	0.507	0.28
14_W	17_R	0.507	0.28
239_I	243_D	0.506	0.28
7_V	78_V	0.506	0.28
176_I	179_E	0.506	0.28
11_I	99_A	0.504	0.28
30_G	84_D	0.502	0.28
38_A	194_V	0.501	0.28
38_A	115_W	0.501	0.28
25_L	90_L	0.501	0.28
191_K	197_K	0.501	0.28
105_L	133_A	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rj1A	2	0.207	13.2	0.95	Contact Map
4gwpA	1	0.2109	10	0.953	Contact Map
2lemA	1	0.7773	9.8	0.953	Contact Map
3ghgA	2	0.5547	9.4	0.953	Contact Map
2xppA	1	0.3359	9.2	0.954	Contact Map
3iykA	3	0.5781	8.9	0.954	Contact Map
2zxxA	2	0.3047	8.7	0.954	Contact Map
3byiA	4	0.4727	8	0.955	Contact Map
1y6uA	1	0.207	6.3	0.957	Contact Map
3r84A	2	0.2109	6.2	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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