GREMLIN Database
DUF3147 - Protein of unknown function (DUF3147)
PFAM: PF11345 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (106)
Sequences: 3165 (2463)
Seq/√Len: 239.2
META: 0.948

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_L105_L3.0461.00
73_V101_V2.9961.00
56_A59_S2.6801.00
78_V82_L2.6581.00
56_A60_D2.6201.00
77_V97_A2.2211.00
57_A60_D2.1581.00
79_W83_P2.0711.00
48_E52_Y2.0601.00
55_E58_A1.9511.00
61_A64_A1.9071.00
11_V38_L1.8601.00
55_E59_S1.8181.00
86_G90_A1.7751.00
74_F78_V1.7371.00
9_G12_V1.7111.00
71_L75_A1.6671.00
67_G71_L1.6361.00
99_L103_V1.5821.00
15_A27_G1.5181.00
42_T46_L1.4881.00
49_G52_Y1.4451.00
12_V16_G1.4411.00
80_L83_P1.4281.00
37_A41_L1.4151.00
85_L93_A1.4131.00
71_L74_F1.3901.00
85_L89_L1.3901.00
70_G102_A1.3671.00
21_R25_K1.3621.00
92_L96_L1.3571.00
7_F11_V1.3551.00
42_T45_E1.3391.00
23_G27_G1.3301.00
75_A79_W1.3091.00
88_L91_L1.3061.00
95_L99_L1.2701.00
18_I26_F1.2521.00
55_E60_D1.2511.00
86_G89_L1.2141.00
5_F8_G1.2121.00
41_L47_E1.1951.00
43_L47_E1.1861.00
100_V107_L1.1841.00
13_V17_L1.1811.00
9_G13_V1.1691.00
78_V83_P1.1641.00
67_G70_G1.1551.00
12_V15_A1.1101.00
76_L80_L1.1101.00
100_V104_L1.0771.00
59_S62_A1.0641.00
70_G73_V1.0581.00
8_G32_A1.0541.00
78_V81_L1.0441.00
49_G53_A1.0221.00
73_V77_V1.0211.00
82_L90_A1.0181.00
89_L92_L0.9941.00
68_A71_L0.9871.00
76_L79_W0.9871.00
73_V97_A0.9751.00
46_L50_K0.9751.00
3_L7_F0.9631.00
90_A94_A0.9601.00
66_L70_G0.9561.00
75_A78_V0.9481.00
85_L90_A0.9371.00
79_W84_R0.9371.00
20_D25_K0.9311.00
96_L99_L0.9171.00
53_A56_A0.9121.00
93_A96_L0.8991.00
46_L49_G0.8941.00
74_F79_W0.8730.99
47_E50_K0.8730.99
22_F26_F0.8620.99
12_V36_I0.8500.99
77_V80_L0.8410.99
85_L88_L0.8050.99
104_L107_L0.8050.99
41_L45_E0.8050.99
13_V31_L0.8050.99
37_A64_A0.7940.99
90_A93_A0.7880.99
92_L104_L0.7860.99
43_L46_L0.7720.99
9_G106_W0.7460.98
60_D63_G0.7390.98
26_F29_L0.7350.98
17_L21_R0.7320.98
26_F30_F0.7280.98
88_L92_L0.7280.98
76_L107_L0.7240.98
18_I30_F0.7240.98
67_G72_L0.7210.98
7_F33_F0.7190.98
100_V103_V0.7190.98
12_V19_A0.6910.97
50_K53_A0.6910.97
64_A67_G0.6910.97
14_A18_I0.6890.97
74_F81_L0.6870.97
17_L20_D0.6810.97
98_W102_A0.6780.97
41_L44_I0.6750.97
6_L76_L0.6740.97
89_L96_L0.6720.97
58_A62_A0.6710.97
73_V93_A0.6700.97
103_V107_L0.6700.97
82_L85_L0.6680.96
4_R43_L0.6620.96
67_G73_V0.6570.96
7_F35_A0.6550.96
79_W82_L0.6510.96
63_G72_L0.6500.96
44_I48_E0.6440.96
45_E50_K0.6400.95
87_A105_L0.6380.95
92_L100_V0.6330.95
43_L48_E0.6320.95
87_A91_L0.6310.95
15_A23_G0.6270.95
77_V93_A0.6060.94
12_V20_D0.6060.94
80_L86_G0.6020.94
48_E51_K0.5950.93
78_V91_L0.5910.93
5_F98_W0.5890.93
44_I47_E0.5840.93
9_G20_D0.5700.92
45_E49_G0.5680.92
64_A68_A0.5680.92
41_L46_L0.5670.92
80_L90_A0.5640.91
10_L14_A0.5630.91
5_F64_A0.5620.91
72_L76_L0.5590.91
9_G29_L0.5490.90
5_F43_L0.5480.90
8_G52_Y0.5450.90
7_F38_L0.5370.89
48_E53_A0.5320.89
69_I73_V0.5290.89
20_D24_P0.5250.88
25_K107_L0.5240.88
61_A70_G0.5230.88
76_L81_L0.5220.88
25_K95_L0.5200.88
56_A100_V0.5140.87
14_A17_L0.5100.87
86_G92_L0.5090.87
2_L51_K0.5080.87
63_G67_G0.5080.87
31_L37_A0.5060.86
16_G24_P0.5050.86
4_R36_I0.5050.86
97_A102_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rceA 1 0.9 28.6 0.859 Contact Map
3wajA 1 0.9182 5.6 0.898 Contact Map
3klyA 3 0.7182 4.3 0.904 Contact Map
4i0uA 4 0.7091 4 0.905 Contact Map
4ev6A 3 0.7273 3 0.911 Contact Map
1iijA 1 0.3182 2.8 0.912 Contact Map
3kcuA 3 0.7273 2 0.919 Contact Map
3zuxA 1 0.9727 1.9 0.919 Contact Map
4n7wA 2 0.9727 1.4 0.926 Contact Map
3w4tA 1 0.9273 1.1 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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