GREMLIN Database
DUF3145 - Protein of unknown function (DUF3145)
PFAM: PF11343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (157)
Sequences: 1689 (777)
Seq/√Len: 62.0
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_E94_H5.2871.00
110_L128_L4.5801.00
98_G102_D3.5971.00
76_S79_V3.5551.00
2_L19_V3.4181.00
96_V104_V3.1571.00
129_D134_T2.9761.00
134_T138_D2.7731.00
114_L128_L2.7201.00
16_E20_A2.4761.00
19_V29_L2.3231.00
7_A15_V2.2631.00
52_G73_E2.2461.00
114_L124_L2.2061.00
124_L128_L2.1291.00
54_G84_Y2.1241.00
75_P81_G1.9801.00
95_A103_I1.9151.00
6_S68_R1.9081.00
112_A116_R1.8941.00
127_E130_R1.8251.00
87_T90_L1.7811.00
80_D100_N1.7400.99
120_G123_E1.6910.99
29_L43_A1.6320.99
68_R139_E1.6180.99
13_P18_A1.5880.99
98_G104_V1.5820.99
113_A127_E1.5740.99
38_P41_L1.5570.99
15_V67_L1.5550.99
29_L45_L1.5540.99
105_V110_L1.5290.98
9_R21_G1.5120.98
80_D99_A1.4550.98
123_E126_H1.4290.98
93_F103_I1.4240.98
8_P11_L1.3930.97
105_V131_L1.3820.97
69_F86_H1.3610.97
54_G69_F1.3440.97
1_V15_V1.3440.97
5_H42_R1.3440.97
14_H17_W1.3060.96
80_D98_G1.2990.96
120_G125_A1.2810.95
152_V156_H1.2760.95
37_A40_T1.2700.95
125_A129_D1.2570.95
85_S93_F1.2440.95
24_G27_V1.2380.95
97_T104_V1.1980.94
51_P76_S1.1860.93
149_G153_R1.1800.93
51_P79_V1.1570.92
116_R127_E1.1520.92
113_A124_L1.1410.92
54_G82_E1.1340.92
68_R72_T1.1250.91
58_A92_I1.0860.90
84_Y92_I1.0810.89
5_H10_A1.0780.89
87_T139_E1.0690.89
50_P56_R1.0630.89
40_T85_S1.0610.89
85_S97_T1.0570.88
141_E144_R1.0570.88
68_R74_E1.0530.88
4_V7_A1.0490.88
84_Y94_H1.0470.88
111_R115_A1.0380.87
7_A94_H1.0230.87
113_A131_L1.0210.87
7_A12_C1.0160.86
114_L125_A0.9980.85
9_R41_L0.9900.85
51_P78_G0.9880.85
112_A115_A0.9610.83
111_R119_G0.9570.83
3_Y9_R0.9550.83
9_R13_P0.9540.83
76_S80_D0.9490.82
55_A84_Y0.9370.81
114_L117_A0.9310.81
94_H97_T0.9250.81
55_A70_E0.9230.80
84_Y90_L0.9100.80
31_W34_Q0.9060.79
9_R36_A0.9030.79
96_V103_I0.8990.79
36_A150_A0.8980.79
121_A125_A0.8910.78
137_D141_E0.8890.78
83_R111_R0.8890.78
33_P41_L0.8890.78
84_Y87_T0.8860.78
54_G57_L0.8840.78
72_T83_R0.8830.77
82_E96_V0.8620.76
37_A66_H0.8500.75
58_A71_V0.8440.74
14_H18_A0.8390.74
89_D139_E0.8320.73
106_P109_R0.8310.73
42_R72_T0.8300.73
119_G125_A0.8250.72
74_E81_G0.8200.72
2_L54_G0.8180.72
114_L129_D0.8170.72
12_C41_L0.8150.72
96_V106_P0.8030.70
74_E83_R0.7980.70
27_V30_D0.7920.69
147_G151_P0.7910.69
140_L144_R0.7890.69
97_T103_I0.7840.69
54_G86_H0.7710.67
80_D104_V0.7700.67
5_H17_W0.7700.67
131_L157_Q0.7680.67
136_W144_R0.7560.66
119_G123_E0.7530.65
67_L116_R0.7510.65
38_P58_A0.7510.65
22_V27_V0.7480.65
139_E143_F0.7430.64
22_V57_L0.7420.64
57_L65_P0.7360.64
9_R86_H0.7360.64
123_E129_D0.7360.64
97_T154_W0.7350.64
21_G26_P0.7220.62
133_G136_W0.7210.62
19_V124_L0.7120.61
111_R121_A0.7120.61
50_P114_L0.7110.61
21_G25_V0.7110.61
77_P115_A0.6990.60
76_S99_A0.6980.60
36_A39_G0.6930.59
23_L62_R0.6910.59
11_L14_H0.6880.58
55_A58_A0.6850.58
61_L72_T0.6830.58
65_P69_F0.6790.57
15_V38_P0.6760.57
112_A127_E0.6740.57
99_A157_Q0.6700.56
122_E126_H0.6660.56
102_D131_L0.6640.56
124_L130_R0.6610.55
37_A143_F0.6570.55
59_S106_P0.6530.55
124_L134_T0.6500.54
84_Y98_G0.6480.54
10_A17_W0.6480.54
52_G55_A0.6390.53
96_V114_L0.6350.53
7_A63_G0.6310.52
7_A20_A0.6300.52
40_T66_H0.6260.52
80_D86_H0.6200.51
130_R135_A0.6190.51
118_A129_D0.6180.51
38_P99_A0.6150.50
26_P69_F0.6150.50
33_P39_G0.6140.50
3_Y81_G0.6130.50
2_L20_A0.6120.50
58_A104_V0.6090.50
73_E76_S0.6090.50
66_H87_T0.6080.49
32_T43_A0.6030.49
45_L71_V0.6020.49
56_R82_E0.6020.49
59_S113_A0.5970.48
113_A138_D0.5930.48
8_P75_P0.5900.47
4_V12_C0.5900.47
153_R156_H0.5890.47
79_V99_A0.5860.47
41_L55_A0.5850.47
146_A153_R0.5820.46
20_A27_V0.5820.46
58_A69_F0.5820.46
103_I108_D0.5760.46
145_H150_A0.5750.46
102_D115_A0.5680.45
49_G52_G0.5640.44
46_S99_A0.5620.44
64_W67_L0.5620.44
10_A14_H0.5600.44
40_T45_L0.5580.44
7_A11_L0.5560.44
90_L136_W0.5540.43
2_L48_Q0.5520.43
62_R66_H0.5460.42
44_E146_A0.5440.42
12_C112_A0.5440.42
75_P78_G0.5430.42
107_E137_D0.5430.42
46_S81_G0.5420.42
27_V67_L0.5410.42
154_W157_Q0.5410.42
98_G120_G0.5410.42
28_S45_L0.5410.42
62_R65_P0.5400.42
96_V109_R0.5380.42
108_D112_A0.5380.42
10_A16_E0.5370.41
86_H131_L0.5320.41
67_L138_D0.5270.40
1_V119_G0.5240.40
97_T124_L0.5230.40
134_T146_A0.5230.40
93_F97_T0.5230.40
92_I98_G0.5210.40
68_R143_F0.5200.40
73_E78_G0.5200.40
7_A97_T0.5200.40
119_G122_E0.5180.39
3_Y12_C0.5170.39
148_D156_H0.5170.39
67_L128_L0.5150.39
110_L130_R0.5130.39
21_G37_A0.5130.39
105_V135_A0.5120.39
47_W54_G0.5100.38
11_L65_P0.5080.38
10_A72_T0.5060.38
105_V111_R0.5060.38
136_W141_E0.5040.38
65_P89_D0.5030.38
87_T153_R0.5020.38
102_D110_L0.5020.38
47_W137_D0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l1wB 1 0.1592 10.6 0.958 Contact Map
2m7eA 1 0.1656 8.7 0.96 Contact Map
2ejaA 2 0.6815 7.9 0.96 Contact Map
3jszA 1 0.5223 7.5 0.961 Contact Map
3u0rA 1 0.121 7.2 0.961 Contact Map
1whzA 1 0.4459 6.7 0.962 Contact Map
4qqwA 2 0.535 6.1 0.963 Contact Map
2elcA 4 0.9618 4.5 0.965 Contact Map
3p8aA 1 0.4841 4.4 0.965 Contact Map
3fegA 2 0.2102 4.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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