GREMLIN Database
DUF3139 - Protein of unknown function (DUF3139)
PFAM: PF11337 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (75)
Sequences: 507 (434)
Seq/√Len: 50.1
META: 0.412

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V66_F2.5611.00
32_V36_L2.5281.00
10_I14_L2.5061.00
66_F70_P2.2621.00
69_E72_V2.2161.00
41_Y64_V2.1491.00
41_Y66_F2.1021.00
54_D58_G1.9340.99
69_E74_Y1.8800.99
19_Y23_N1.8590.99
39_K68_D1.8520.99
6_I45_D1.8020.99
41_Y45_D1.7610.99
10_I13_L1.7590.99
67_K75_Y1.6550.98
45_D68_D1.5120.97
51_T66_F1.4670.96
9_I17_I1.4520.96
35_Y39_K1.3970.95
47_K65_V1.3770.94
24_P29_A1.3540.94
7_I10_I1.3460.94
30_K46_I1.3390.94
50_K75_Y1.2950.92
10_I17_I1.2630.91
57_K62_V1.2300.90
51_T55_S1.2260.90
51_T62_V1.2130.90
30_K34_E1.2010.89
54_D57_K1.1920.89
50_K63_E1.1730.88
36_L41_Y1.1490.87
46_I76_Y1.1480.87
65_V71_N1.0730.83
19_Y24_P1.0650.83
18_G22_Y1.0390.81
35_Y68_D1.0350.81
33_D49_I1.0070.79
12_I71_N0.9950.78
8_I13_L0.9730.76
64_V70_P0.9680.76
37_E73_T0.9500.75
4_I12_I0.9170.72
53_Y59_G0.9110.72
43_E56_K0.9110.72
58_G61_Y0.9100.72
11_L14_L0.9070.71
47_K67_K0.9030.71
7_I52_K0.9000.71
36_L39_K0.8910.70
12_I16_V0.8720.68
43_E51_T0.8680.68
49_I62_V0.8640.68
63_E73_T0.8630.67
57_K60_Y0.8550.67
51_T59_G0.8250.64
42_K61_Y0.8200.63
4_I11_L0.8120.63
45_D48_S0.8060.62
37_E50_K0.8020.62
4_I14_L0.8000.62
41_Y69_E0.7920.61
20_I23_N0.7810.60
16_V71_N0.7770.59
11_L16_V0.7770.59
4_I7_I0.7650.58
44_S67_K0.7600.58
34_E47_K0.7580.57
4_I16_V0.7570.57
21_G24_P0.7430.56
32_V62_V0.7150.53
53_Y57_K0.7130.53
38_E45_D0.7060.52
66_F74_Y0.6990.51
63_E71_N0.6970.51
32_V61_Y0.6970.51
41_Y53_Y0.6910.51
3_K9_I0.6830.50
11_L27_Y0.6750.49
23_N26_Q0.6660.48
9_I15_I0.6540.47
35_Y46_I0.6480.46
37_E72_V0.6460.46
54_D72_V0.6330.45
42_K48_S0.6320.45
21_G26_Q0.6310.44
16_V42_K0.6290.44
36_L69_E0.6240.44
40_G44_S0.6220.43
8_I43_E0.6200.43
21_G25_Y0.6180.43
53_Y56_K0.6060.42
10_I15_I0.5990.41
6_I10_I0.5870.40
48_S70_P0.5840.40
7_I15_I0.5800.39
25_Y29_A0.5680.38
53_Y61_Y0.5670.38
42_K67_K0.5570.37
33_D37_E0.5540.37
19_Y67_K0.5520.37
20_I24_P0.5500.36
43_E47_K0.5480.36
5_I9_I0.5420.36
5_I8_I0.5240.34
9_I20_I0.5220.34
57_K73_T0.5150.33
39_K69_E0.5140.33
35_Y56_K0.5090.33
66_F72_V0.5090.33
33_D43_E0.5020.32
19_Y22_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5lA 1 0 47.7 0.803 Contact Map
1qqhA 2 0.6842 32 0.822 Contact Map
3hvnA 1 0.6053 16.4 0.845 Contact Map
2m8rA 1 0.3421 16.1 0.845 Contact Map
4m1bA 1 0.3553 15.4 0.847 Contact Map
2k3dA 1 0.6447 13.1 0.851 Contact Map
2w3zA 1 0.6184 7.1 0.868 Contact Map
1tueB 1 0.9342 6.9 0.869 Contact Map
2jexA 1 0.9342 6.9 0.869 Contact Map
1pfoA 2 0.6974 5.3 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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