GREMLIN Database
DUF3137 - Protein of unknown function (DUF3137)
PFAM: PF11335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (136)
Sequences: 3806 (3108)
Seq/√Len: 266.5
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L87_L4.1201.00
41_V56_S3.7451.00
25_D49_E3.2731.00
9_V93_K3.2131.00
18_G57_T2.9541.00
51_K78_K2.9371.00
45_D75_L2.5591.00
45_D72_E2.5381.00
51_K75_L2.4521.00
72_E76_E2.2551.00
59_Q63_R2.2111.00
51_K79_K2.1031.00
11_D92_N2.1021.00
103_D106_E2.0591.00
11_D93_K2.0151.00
39_E59_Q1.9021.00
24_P86_R1.8711.00
44_E49_E1.8481.00
20_T56_S1.7761.00
40_R53_E1.7591.00
41_V62_A1.7441.00
14_K64_Y1.7221.00
7_F95_Y1.7001.00
38_L57_T1.5631.00
45_D71_M1.5291.00
127_A131_D1.5121.00
19_R90_V1.4891.00
47_E79_K1.4871.00
86_R99_P1.4821.00
43_L71_M1.4601.00
12_F16_F1.4471.00
25_D53_E1.4261.00
60_V63_R1.4171.00
44_E68_P1.4021.00
117_E120_R1.3821.00
17_K61_E1.3811.00
40_R55_Y1.3301.00
19_R57_T1.3261.00
130_L134_D1.2941.00
80_K135_E1.2851.00
86_R97_A1.2371.00
40_R49_E1.2291.00
116_F120_R1.2231.00
47_E75_L1.2231.00
120_R124_E1.2191.00
122_Y125_E1.2031.00
44_E63_R1.1921.00
22_V87_L1.1871.00
26_K29_F1.1691.00
56_S62_A1.1591.00
7_F97_A1.1591.00
100_T104_L1.1571.00
61_E65_I1.1501.00
6_L104_L1.1481.00
24_P78_K1.1321.00
15_N92_N1.1181.00
118_R121_E1.1151.00
115_D118_R1.1101.00
20_T61_E1.1101.00
76_E80_K1.1001.00
125_E130_L1.1001.00
63_R68_P1.0951.00
41_V59_Q1.0301.00
48_F54_V1.0291.00
26_K30_F1.0281.00
20_T65_I1.0251.00
69_S73_R1.0161.00
87_L94_L1.0101.00
9_V95_Y1.0061.00
25_D40_R0.9971.00
118_R122_Y0.9931.00
32_S35_G0.9771.00
128_L131_D0.9681.00
44_E64_Y0.9671.00
22_V54_V0.9601.00
67_T71_M0.9591.00
31_F34_K0.9521.00
125_E129_I0.9441.00
46_P50_K0.9241.00
6_L100_T0.9221.00
60_V64_Y0.9201.00
23_L55_Y0.9151.00
18_G56_S0.9131.00
15_N91_G0.9041.00
29_F32_S0.9021.00
47_E72_E0.8971.00
10_A94_L0.8921.00
27_K30_F0.8891.00
43_L60_V0.8851.00
43_L63_R0.8781.00
77_L81_F0.8771.00
44_E71_M0.8661.00
23_L86_R0.8611.00
43_L54_V0.8461.00
30_F33_K0.8451.00
47_E50_K0.8431.00
12_F94_L0.8320.99
21_V38_L0.8280.99
4_K103_D0.8150.99
78_K83_G0.8070.99
58_D61_E0.7930.99
30_F34_K0.7930.99
16_F65_I0.7880.99
66_L71_M0.7790.99
76_E79_K0.7750.99
73_R77_L0.7740.99
27_K31_F0.7670.99
56_S59_Q0.7550.99
68_P72_E0.7400.99
52_F75_L0.7330.99
44_E60_V0.7330.99
84_K99_P0.7320.99
60_V71_M0.7290.99
116_F119_I0.7260.99
102_K121_E0.7200.98
23_L53_E0.7200.98
122_Y129_I0.7140.98
28_G31_F0.7120.98
100_T125_E0.7120.98
119_I122_Y0.7090.98
108_S118_R0.7030.98
43_L64_Y0.6990.98
12_F64_Y0.6970.98
64_Y71_M0.6950.98
110_F113_L0.6930.98
47_E51_K0.6920.98
20_T24_P0.6850.98
43_L49_E0.6810.98
16_F92_N0.6810.98
127_A130_L0.6690.97
18_G61_E0.6690.97
122_Y130_L0.6630.97
71_M75_L0.6580.97
27_K32_S0.6560.97
19_R36_S0.6560.97
13_N92_N0.6450.97
122_Y127_A0.6450.97
17_K91_G0.6370.97
123_Y126_L0.6350.97
42_K46_P0.6320.96
4_K99_P0.6320.96
69_S137_N0.6310.96
107_P110_F0.6300.96
27_K33_K0.6240.96
70_F129_I0.6240.96
80_K124_E0.6190.96
49_E53_E0.6180.96
131_D135_E0.6140.96
60_V69_S0.6070.96
58_D63_R0.6070.96
58_D64_Y0.6070.96
48_F52_F0.6030.95
52_F85_I0.6030.95
17_K58_D0.6000.95
46_P63_R0.5980.95
20_T89_F0.5970.95
123_Y127_A0.5960.95
6_L129_I0.5950.95
26_K31_F0.5940.95
12_F67_T0.5870.95
20_T57_T0.5860.95
34_K37_G0.5820.94
113_L118_R0.5810.94
33_K36_S0.5810.94
43_L66_L0.5780.94
11_D14_K0.5780.94
14_K44_E0.5780.94
83_G100_T0.5760.94
77_L128_L0.5730.94
112_S115_D0.5700.94
22_V66_L0.5680.94
72_E75_L0.5650.94
16_F89_F0.5620.93
70_F74_L0.5590.93
20_T62_A0.5550.93
25_D54_V0.5490.93
87_L107_P0.5490.93
42_K49_E0.5470.92
21_V88_S0.5440.92
61_E64_Y0.5420.92
117_E124_E0.5390.92
78_K82_G0.5380.92
24_P97_A0.5370.92
24_P84_K0.5360.92
109_I112_S0.5330.91
34_K38_L0.5320.91
102_K125_E0.5310.91
124_E127_A0.5310.91
121_E124_E0.5230.91
28_G32_S0.5220.91
70_F73_R0.5180.90
65_I89_F0.5180.90
16_F61_E0.5180.90
10_A13_N0.5180.90
69_S135_E0.5170.90
32_S36_S0.5130.90
118_R123_Y0.5110.90
69_S72_E0.5080.89
130_L133_V0.5080.89
49_E55_Y0.5050.89
117_E123_Y0.5050.89
43_L59_Q0.5030.89
6_L99_P0.5020.89
6_L10_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hzmA 1 0.4565 4.3 0.915 Contact Map
2z4tA 1 0.6667 3.4 0.92 Contact Map
3fhkA 4 0.4058 2.5 0.925 Contact Map
2ga1A 2 0.6304 1.7 0.931 Contact Map
4b6hA 1 0.5072 1.4 0.934 Contact Map
1hyuA 2 0.3768 1.4 0.934 Contact Map
3ro3B 1 0.0942 1.4 0.935 Contact Map
3wolA 2 0.8333 1.4 0.935 Contact Map
4dcuA 1 0.6304 1.2 0.937 Contact Map
4r84A 1 0.6159 1.1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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