GREMLIN Database
DUF3135 - Protein of unknown function (DUF3135)
PFAM: PF11333 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (77)
Sequences: 1397 (1083)
Seq/√Len: 123.4
META: 0.862

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E14_E2.7871.00
28_E43_R2.4101.00
28_E32_A2.3041.00
3_F8_W2.2891.00
15_D18_A2.2391.00
40_R44_G2.1661.00
9_A13_K2.1001.00
44_G47_W2.0871.00
34_A42_L2.0521.00
51_M55_R1.9731.00
46_Q50_D1.8551.00
52_E65_R1.8351.00
7_E22_L1.8171.00
20_E23_R1.6881.00
39_Q43_R1.6801.00
49_I66_I1.5861.00
58_N61_A1.5801.00
4_D7_E1.5241.00
47_W51_M1.5231.00
52_E55_R1.4541.00
30_L34_A1.4381.00
51_M54_R1.4261.00
71_W74_L1.4171.00
8_W22_L1.3661.00
53_R62_A1.3451.00
5_F9_A1.3421.00
18_A21_A1.3251.00
3_F22_L1.3231.00
56_A61_A1.2921.00
26_L29_E1.2330.99
57_K61_A1.2150.99
48_R52_E1.2140.99
41_R44_G1.1640.99
31_I34_A1.1580.99
27_I46_Q1.1400.99
30_L33_S1.1350.99
67_S70_M1.1280.99
60_L63_C1.1130.99
32_A39_Q1.0980.99
8_W26_L1.0930.99
21_A25_E1.0300.98
76_E79_G1.0270.98
19_F27_I1.0130.98
26_L30_L1.0010.98
64_I67_S0.9910.97
70_M73_S0.9770.97
44_G51_M0.9720.97
56_A65_R0.9700.97
63_C67_S0.9560.97
36_E39_Q0.9170.96
24_R28_E0.9040.96
22_L25_E0.8860.95
65_R68_R0.8820.95
23_R53_R0.8740.95
7_E11_L0.8500.94
73_S76_E0.8440.94
11_L22_L0.8230.93
8_W19_F0.7990.92
3_F19_F0.7660.90
35_P38_Q0.7610.90
53_R66_I0.7500.89
61_A64_I0.7480.89
52_E69_M0.7240.87
19_F30_L0.7190.87
56_A62_A0.7180.87
19_F71_W0.7040.86
31_I46_Q0.6910.85
35_P39_Q0.6820.84
40_R75_A0.6790.84
24_R50_D0.6770.83
25_E29_E0.6740.83
60_L64_I0.6710.83
19_F23_R0.6670.83
74_L78_R0.6650.82
27_I30_L0.6580.82
70_M77_L0.6540.81
27_I31_I0.6380.80
19_F22_L0.6340.79
64_I68_R0.6300.79
25_E28_E0.6290.79
62_A66_I0.6260.78
44_G48_R0.6190.78
12_A19_F0.6110.77
47_W77_L0.6040.76
18_A25_E0.6020.76
18_A22_L0.6010.76
27_I50_D0.5960.75
47_W74_L0.5950.75
49_I63_C0.5900.74
6_D9_A0.5880.74
67_S71_W0.5840.74
34_A38_Q0.5790.73
20_E53_R0.5730.72
73_S77_L0.5690.72
47_W71_W0.5670.71
57_K68_R0.5660.71
61_A65_R0.5650.71
46_Q66_I0.5650.71
11_L15_D0.5630.71
63_C66_I0.5590.70
41_R47_W0.5560.70
65_R69_M0.5530.69
26_L54_R0.5520.69
62_A70_M0.5460.68
16_P59_P0.5410.68
38_Q75_A0.5410.68
66_I70_M0.5320.67
34_A39_Q0.5310.66
26_L56_A0.5310.66
43_R50_D0.5310.66
48_R69_M0.5280.66
38_Q74_L0.5270.66
58_N64_I0.5230.65
14_E21_A0.5130.64
21_A32_A0.5020.62
49_I53_R0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iyuX 3 0.6296 12.3 0.882 Contact Map
4uopA 2 0.4568 11.2 0.884 Contact Map
2p0tA 1 0.9383 8.5 0.89 Contact Map
2p22C 2 0.9877 8 0.891 Contact Map
3bboS 1 0.3704 7.8 0.892 Contact Map
1i7kA 1 0.3827 6.9 0.895 Contact Map
3l1nA 2 0.7407 6.1 0.897 Contact Map
1zkrA 2 0.963 5.9 0.898 Contact Map
1yrvA 1 0.3333 5.6 0.899 Contact Map
4nooA 1 0.8642 5.5 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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