GREMLIN Database
DUF3128 - Protein of unknown function (DUF3128)
PFAM: PF11326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (78)
Sequences: 575 (423)
Seq/√Len: 47.9
META: 0.301

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E60_E4.1311.00
4_C43_C3.4761.00
16_S19_G2.6781.00
62_E65_R2.5471.00
20_Q23_Q2.2811.00
35_Q39_D2.0981.00
76_W79_R2.0381.00
49_K53_E1.9070.99
60_E64_E1.8990.99
51_P55_R1.8630.99
6_Q10_E1.8400.99
66_K69_R1.6070.97
7_Y42_F1.5780.97
52_E55_R1.5750.97
13_F16_S1.4950.96
71_S74_D1.4620.95
11_A15_Y1.4470.95
70_P78_L1.4460.95
22_H36_W1.3460.93
50_K53_E1.3380.93
10_E36_W1.3190.92
7_Y10_E1.3090.92
61_R64_E1.2990.92
38_E77_E1.2820.91
12_F18_G1.2730.91
2_M7_Y1.2590.90
62_E66_K1.2520.90
11_A41_K1.2350.89
50_K57_A1.2100.88
64_E68_E1.1860.87
54_A58_L1.1440.85
38_E60_E1.1070.84
69_R74_D1.0990.83
3_S24_Y1.0830.82
5_R30_L1.0650.81
6_Q9_D1.0570.81
5_R9_D1.0460.80
44_M47_K1.0170.78
7_Y58_L1.0150.78
8_F25_Y1.0130.78
14_C33_C1.0130.78
15_Y24_Y1.0070.77
49_K52_E0.9590.74
17_L32_D0.9520.73
70_P74_D0.9490.73
11_A37_W0.9390.72
19_G31_D0.9300.71
20_Q31_D0.9250.71
48_T56_E0.9220.71
51_P58_L0.9210.71
25_Y31_D0.9210.71
40_F61_R0.9120.70
39_D62_E0.8950.68
17_L52_E0.8840.67
21_F43_C0.8600.65
4_C14_C0.8530.65
52_E64_E0.8500.64
41_K45_R0.8330.63
27_Y48_T0.8080.60
42_F58_L0.8060.60
10_E39_D0.7900.59
5_R11_A0.7740.57
37_W41_K0.7650.56
56_E78_L0.7640.56
48_T52_E0.7560.55
17_L40_F0.7540.55
56_E77_E0.7500.55
4_C16_S0.7390.54
26_R71_S0.7280.53
9_D20_Q0.7270.52
23_Q29_E0.7120.51
8_F47_K0.7070.50
21_F68_E0.7010.50
7_Y54_A0.6970.49
31_D35_Q0.6930.49
9_D26_R0.6920.49
7_Y62_E0.6880.49
17_L68_E0.6870.48
6_Q13_F0.6870.48
17_L30_L0.6750.47
19_G30_L0.6630.46
25_Y76_W0.6620.46
38_E61_R0.6510.45
60_E63_A0.6490.45
5_R52_E0.6310.43
59_R69_R0.6300.43
21_F29_E0.6230.42
19_G29_E0.6220.42
39_D61_R0.6040.40
70_P73_E0.5990.40
34_S44_M0.5950.39
34_S77_E0.5930.39
69_R73_E0.5920.39
49_K56_E0.5780.38
71_S78_L0.5700.37
29_E62_E0.5670.37
12_F60_E0.5640.36
2_M42_F0.5620.36
2_M39_D0.5580.36
65_R69_R0.5490.35
3_S77_E0.5480.35
27_Y68_E0.5470.35
43_C79_R0.5460.35
75_V79_R0.5420.34
13_F19_G0.5400.34
55_R78_L0.5360.34
9_D38_E0.5350.34
2_M5_R0.5350.34
29_E35_Q0.5290.33
25_Y30_L0.5290.33
29_E32_D0.5280.33
3_S10_E0.5260.33
49_K55_R0.5210.33
22_H39_D0.5130.32
18_G42_F0.5120.32
9_D59_R0.5050.31
10_E78_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xizM 1 0.8101 20.9 0.869 Contact Map
4xhrN 1 0.8228 9.2 0.888 Contact Map
2riqA 2 0.3038 2.1 0.919 Contact Map
4tpvA 2 0.519 1.9 0.92 Contact Map
4lirA 2 0.9114 1.8 0.921 Contact Map
3lb6A 1 0.3924 1.7 0.922 Contact Map
5aj3m 1 0.8481 1.7 0.922 Contact Map
1zhxA 1 0.9873 1.6 0.923 Contact Map
4b2zA 1 0.9747 1.6 0.924 Contact Map
2yg2A 1 0.4304 1.5 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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