GREMLIN Database
DUF3126 - Protein of unknown function (DUF3126)
PFAM: PF11324 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (63)
Sequences: 2899 (1227)
Seq/√Len: 154.6
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_Q10_R3.2371.00
44_R51_R3.1721.00
32_V55_F3.0751.00
21_V33_Y2.9991.00
23_R29_S2.3611.00
8_Y12_L2.1571.00
3_A6_Q2.0131.00
46_D51_R1.9751.00
33_Y36_E1.8821.00
14_G17_R1.8041.00
29_S41_V1.6171.00
34_I39_I1.5471.00
17_R35_G1.4711.00
20_V30_A1.4571.00
15_N34_I1.4501.00
40_G57_M1.4381.00
23_R41_V1.4011.00
32_V42_L1.3931.00
38_F41_V1.3671.00
47_E50_E1.3491.00
23_R31_E1.3351.00
54_N58_A1.3131.00
18_I34_I1.2991.00
7_A11_R1.2921.00
19_R36_E1.2471.00
40_G55_F1.1881.00
1_E44_R1.1721.00
10_R16_P1.1411.00
23_R28_D1.1211.00
10_R15_N1.0580.99
29_S43_F1.0440.99
55_F59_I1.0200.99
51_R54_N1.0020.99
5_L9_L0.9570.98
18_I32_V0.9320.98
31_E38_F0.9270.98
4_K8_Y0.8900.98
26_K29_S0.8500.97
60_L63_D0.8470.97
22_P25_K0.8160.96
46_D50_E0.8110.96
9_L40_G0.8070.96
32_V39_I0.7990.95
38_F43_F0.7910.95
8_Y11_R0.7900.95
3_A7_A0.7710.94
43_F56_Q0.7650.94
1_E4_K0.7220.92
45_D54_N0.7110.92
48_D52_S0.6880.90
31_E41_V0.6870.90
44_R53_Y0.6860.90
26_K43_F0.6800.90
40_G45_D0.6790.90
23_R43_F0.6770.90
44_R50_E0.6670.89
12_L37_E0.6620.89
10_R18_I0.6590.88
1_E53_Y0.6500.88
34_I40_G0.6390.87
45_D48_D0.6380.87
9_L32_V0.6280.86
19_R33_Y0.6270.86
2_I30_A0.6240.86
7_A16_P0.6160.85
51_R56_Q0.6150.85
51_R61_D0.6080.84
11_R14_G0.6070.84
15_N19_R0.5950.83
12_L34_I0.5950.83
37_E43_F0.5910.82
53_Y62_I0.5730.80
14_G22_P0.5730.80
29_S37_E0.5720.80
14_G19_R0.5710.80
44_R49_G0.5710.80
3_A14_G0.5570.78
23_R42_L0.5450.77
28_D38_F0.5410.76
3_A10_R0.5380.76
21_V24_P0.5350.76
50_E53_Y0.5310.75
38_F57_M0.5280.75
11_R25_K0.5240.74
38_F58_A0.5220.74
42_L55_F0.5220.74
2_I5_L0.5190.73
46_D49_G0.5190.73
5_L10_R0.5160.73
38_F44_R0.5150.73
41_V58_A0.5120.72
6_Q15_N0.5110.72
34_I37_E0.5080.72
50_E62_I0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4madA 1 0.9524 34.5 0.864 Contact Map
1jmxA 1 0.9841 34.2 0.865 Contact Map
3d3aA 1 0.9206 28.9 0.869 Contact Map
3w5fA 1 0.9524 27.5 0.871 Contact Map
4e8dA 2 0.9524 18.5 0.881 Contact Map
3pl5A 1 0.7302 14.6 0.886 Contact Map
3tpdA 1 0.5556 12 0.891 Contact Map
3jr7A 1 0.6349 11.3 0.892 Contact Map
2g7zA 3 0.6667 11.3 0.892 Contact Map
3fysA 1 0.6825 10.3 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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