GREMLIN Database
DUF3124 - Protein of unknown function (DUF3124)
PFAM: PF11322 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (122)
Sequences: 2507 (1700)
Seq/√Len: 153.9
META: 0.881

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_D55_S3.9611.00
4_V101_I3.4311.00
8_V25_A3.3951.00
38_I96_V3.3701.00
4_V120_G3.0711.00
43_V71_F2.6061.00
47_D51_K2.3091.00
102_E119_R2.2951.00
24_T72_V2.2041.00
41_T91_K2.1441.00
54_R79_S2.1331.00
44_D52_L2.0991.00
27_L88_V1.9221.00
32_T97_N1.7991.00
103_A118_S1.7451.00
70_E82_S1.7231.00
3_T89_E1.7131.00
64_K67_A1.7091.00
11_H82_S1.6431.00
33_D36_D1.6401.00
22_L78_T1.6191.00
49_D67_A1.5991.00
8_V103_A1.5901.00
26_T106_I1.5881.00
6_V27_L1.5721.00
3_T87_I1.5061.00
34_P66_L1.4981.00
33_D97_N1.4951.00
102_E118_S1.4721.00
46_Y85_N1.3821.00
48_T85_N1.3671.00
36_D94_K1.3641.00
52_L55_S1.3281.00
39_T91_K1.3181.00
42_S89_E1.2911.00
45_Y80_G1.2761.00
100_I121_R1.2761.00
11_H22_L1.2741.00
66_L87_I1.2621.00
21_F112_Q1.2541.00
67_A85_N1.2031.00
2_Q122_V1.2001.00
98_E122_V1.1881.00
32_T100_I1.1711.00
81_G86_F1.1701.00
108_T112_Q1.1681.00
43_V57_L1.1581.00
41_T89_E1.1521.00
14_S21_F1.1431.00
100_I119_R1.1060.99
56_Y86_F1.0950.99
55_S58_D1.0670.99
107_G115_S1.0660.99
37_P62_T1.0610.99
101_I120_G1.0540.99
38_I99_P1.0390.99
27_L86_F1.0330.99
68_S85_N1.0300.99
107_G114_I1.0250.99
92_A96_V1.0240.99
98_E121_R1.0210.99
18_E72_V1.0070.99
34_P87_I1.0070.99
63_L67_A1.0030.99
92_A95_P0.9990.99
66_L85_N0.9940.99
16_D76_S0.9720.99
108_T113_G0.9640.99
5_Y30_R0.9570.98
6_V88_V0.9530.98
30_R85_N0.9390.98
108_T114_I0.9310.98
28_S82_S0.9030.98
88_V101_I0.8980.98
46_Y52_L0.8970.98
13_Y24_T0.8950.98
12_I23_L0.8950.98
28_S83_G0.8880.98
56_Y73_I0.8730.97
75_E109_S0.8670.97
44_D89_E0.8660.97
27_L43_V0.8610.97
54_R58_D0.8610.97
61_I69_T0.8520.97
14_S24_T0.8470.97
30_R70_E0.8400.97
77_D80_G0.8380.96
62_T93_D0.8350.96
118_S121_R0.8280.96
106_I115_S0.8270.96
62_T65_P0.8170.96
108_T111_Q0.8130.96
38_I63_L0.8080.96
6_V101_I0.8020.95
13_Y82_S0.8010.95
33_D96_V0.7910.95
11_H20_P0.7900.95
23_L114_I0.7880.95
105_M115_S0.7660.94
97_N123_I0.7640.94
42_S55_S0.7630.94
106_I114_I0.7530.94
57_L61_I0.7470.93
54_R77_D0.7450.93
12_I106_I0.7440.93
77_D81_G0.7440.93
10_S45_Y0.7350.93
53_V78_T0.7310.93
30_R104_V0.7290.93
12_I104_V0.7260.92
2_Q98_E0.7200.92
105_M113_G0.7170.92
39_T62_T0.7070.91
10_S77_D0.7020.91
30_R66_L0.6990.91
13_Y72_V0.6940.91
48_T68_S0.6890.90
13_Y28_S0.6810.90
106_I111_Q0.6730.89
49_D64_K0.6700.89
106_I113_G0.6630.89
20_P82_S0.6590.88
48_T83_G0.6560.88
43_V53_V0.6510.88
93_D96_V0.6460.87
7_P102_E0.6420.87
32_T117_T0.6410.87
48_T82_S0.6410.87
19_R22_L0.6360.86
68_S82_S0.6340.86
35_K94_K0.6210.85
9_Y12_I0.6180.85
18_E70_E0.6120.84
4_V9_Y0.6110.84
25_A105_M0.6090.84
11_H30_R0.6050.84
16_D75_E0.6010.83
73_I86_F0.6000.83
80_G83_G0.5970.83
37_P64_K0.5960.83
29_I69_T0.5910.82
6_V103_A0.5900.82
13_Y26_T0.5860.82
34_P42_S0.5770.81
7_P10_S0.5740.80
48_T70_E0.5730.80
13_Y70_E0.5730.80
29_I38_I0.5720.80
110_G114_I0.5720.80
21_F107_G0.5690.80
54_R74_E0.5670.80
20_P24_T0.5660.79
53_V79_S0.5630.79
87_I123_I0.5580.78
45_Y84_A0.5570.78
17_K20_P0.5560.78
22_L75_E0.5540.78
3_T34_P0.5530.78
13_Y20_P0.5520.78
36_D93_D0.5510.78
11_H18_E0.5510.78
38_I43_V0.5510.78
8_V85_N0.5490.77
7_P14_S0.5470.77
108_T115_S0.5450.77
74_E78_T0.5400.76
34_P44_D0.5390.76
39_T60_P0.5350.76
30_R80_G0.5330.75
47_D85_N0.5290.75
75_E107_G0.5280.75
16_D72_V0.5280.75
57_L60_P0.5220.74
43_V88_V0.5200.73
25_A103_A0.5170.73
26_T82_S0.5130.72
10_S73_I0.5100.72
55_S94_K0.5080.72
22_L76_S0.5060.71
39_T67_A0.5030.71
4_V7_P0.5030.71
15_G70_E0.5010.71
90_W96_V0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f2gA 1 0.8211 13.9 0.939 Contact Map
2c5lC 1 0.6829 13 0.94 Contact Map
2ww2A 3 0.6992 8 0.945 Contact Map
1oh4A 1 0.4146 7.9 0.945 Contact Map
2oqoA 2 0.4634 7.7 0.946 Contact Map
2byeA 1 0.8374 7 0.947 Contact Map
3d8cA 2 0.6016 6.2 0.948 Contact Map
2wvxA 2 0.7154 5.4 0.949 Contact Map
4gioA 1 0.7073 5.3 0.95 Contact Map
3sluA 1 0.9756 4.7 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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