GREMLIN Database
DUF3119 - Protein of unknown function (DUF3119)
PFAM: PF11317 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (113)
Sequences: 517 (364)
Seq/√Len: 34.3
META: 0.702

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L12_V4.5231.00
14_V35_G3.5221.00
113_D116_Q3.2691.00
47_L54_L3.0311.00
59_G63_E2.8241.00
9_L13_L2.7251.00
45_L56_V2.5971.00
34_F45_L2.5171.00
118_R122_E2.4551.00
17_G32_A2.4001.00
10_P42_T2.3650.99
53_A72_R2.2330.99
80_N95_K2.0360.98
9_L111_L1.8900.97
79_Q95_K1.8290.97
57_Y66_I1.7930.96
120_C123_Q1.7050.95
49_F54_L1.6720.94
2_E48_Q1.6710.94
48_Q55_D1.5720.92
26_W29_L1.5570.92
77_E97_V1.5490.92
36_L40_V1.5370.91
29_L123_Q1.5000.90
80_N107_F1.4350.88
56_V66_I1.4210.88
45_L59_G1.3890.87
91_L105_I1.3810.86
34_F37_F1.3760.86
22_L87_P1.2940.82
13_L17_G1.2800.82
13_L16_L1.2470.80
20_L31_I1.2460.80
73_F78_W1.2380.79
14_V36_L1.2280.79
106_H109_P1.2220.79
92_F108_L1.2180.78
8_R12_V1.2100.78
55_D65_L1.1820.76
7_Y57_Y1.1750.76
78_W117_L1.1680.75
65_L72_R1.1640.75
34_F44_T1.1570.75
29_L32_A1.1270.73
45_L72_R1.1220.72
25_P30_V1.1180.72
72_R124_R1.1150.72
34_F38_L1.0940.70
42_T115_K1.0770.69
9_L77_E1.0730.69
11_L29_L1.0550.68
2_E80_N1.0160.65
78_W92_F1.0090.64
34_F66_I0.9990.63
99_S121_L0.9750.61
52_T56_V0.9640.60
7_Y43_A0.9540.60
35_G39_L0.9330.58
20_L23_L0.9300.58
1_V124_R0.9240.57
25_P28_G0.9240.57
80_N125_C0.9210.57
36_L42_T0.9150.56
36_L48_Q0.9080.56
17_G35_G0.9000.55
9_L16_L0.8970.55
76_S97_V0.8860.54
50_T72_R0.8820.54
8_R11_L0.8760.53
73_F92_F0.8670.52
117_L121_L0.8590.52
75_Y78_W0.8570.52
18_L32_A0.8550.51
74_P77_E0.8440.50
2_E7_Y0.8410.50
85_W105_I0.8370.50
4_A8_R0.8360.50
64_N124_R0.8320.49
53_A75_Y0.8300.49
18_L22_L0.8250.49
12_V16_L0.8240.49
1_V123_Q0.8120.48
120_C125_C0.8090.47
6_S9_L0.8050.47
92_F99_S0.7950.46
22_L35_G0.7910.46
11_L15_L0.7810.45
116_Q119_E0.7570.43
112_F121_L0.7560.43
74_P78_W0.7450.42
14_V43_A0.7450.42
39_L43_A0.7290.41
73_F108_L0.7250.40
6_S44_T0.7180.40
9_L88_V0.7090.39
18_L83_I0.7080.39
22_L27_L0.7070.39
64_N76_S0.7030.39
73_F99_S0.7010.38
97_V107_F0.6970.38
87_P118_R0.6950.38
32_A113_D0.6830.37
14_V40_V0.6790.37
50_T53_A0.6710.36
8_R13_L0.6700.36
6_S114_P0.6660.36
44_T58_R0.6660.36
4_A116_Q0.6650.36
82_R111_L0.6600.35
86_P118_R0.6600.35
35_G95_K0.6590.35
110_I114_P0.6590.35
40_V98_K0.6570.35
99_S108_L0.6430.34
48_Q63_E0.6390.34
81_W112_F0.6390.34
40_V91_L0.6370.33
37_F40_V0.6320.33
98_K107_F0.6310.33
119_E123_Q0.6230.32
12_V48_Q0.6200.32
118_R124_R0.6190.32
56_V81_W0.6170.32
21_L39_L0.6150.32
19_P22_L0.6140.32
78_W81_W0.6140.32
45_L55_D0.6140.32
67_R92_F0.6110.32
47_L92_F0.6110.32
34_F125_C0.6070.31
75_Y85_W0.6060.31
74_P112_F0.6030.31
20_L24_Q0.6030.31
44_T56_V0.6010.31
10_P110_I0.5900.30
6_S110_I0.5870.30
15_L22_L0.5860.30
82_R107_F0.5850.30
35_G91_L0.5850.30
25_P64_N0.5840.30
4_A10_P0.5820.29
37_F112_F0.5780.29
10_P13_L0.5660.28
5_P16_L0.5640.28
47_L73_F0.5630.28
25_P29_L0.5620.28
22_L25_P0.5600.28
30_V123_Q0.5570.28
119_E122_E0.5490.27
56_V108_L0.5480.27
116_Q123_Q0.5470.27
17_G120_C0.5470.27
39_L87_P0.5440.27
1_V25_P0.5430.27
47_L108_L0.5400.27
18_L122_E0.5390.27
40_V44_T0.5300.26
55_D63_E0.5280.26
21_L25_P0.5270.26
86_P116_Q0.5230.25
85_W88_V0.5200.25
19_P23_L0.5150.25
115_K118_R0.5130.25
21_L28_G0.5130.25
8_R88_V0.5130.25
39_L111_L0.5100.25
56_V65_L0.5080.25
110_I121_L0.5060.24
73_F121_L0.5050.24
43_A58_R0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j0wA 1 0.6587 10 0.95 Contact Map
1ciiA 1 0.4444 8.6 0.952 Contact Map
3hrgA 1 0.9048 5 0.957 Contact Map
3fm7C 1 0.2143 4.1 0.959 Contact Map
3glwZ 2 0.1349 3.7 0.959 Contact Map
2p8iA 2 0.3095 3.5 0.96 Contact Map
1g8mA 2 0.5 3.3 0.96 Contact Map
2dlwA 1 0.6984 3.3 0.96 Contact Map
1xr0B 1 0.6587 3 0.961 Contact Map
1yumA 4 0.9683 3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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