GREMLIN Database
DUF3109 - Protein of unknown function (DUF3109)
PFAM: PF11307 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 181 (180)
Sequences: 6126 (3975)
Seq/√Len: 296.3
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E172_F2.7151.00
55_K63_I2.6141.00
174_E178_E2.6071.00
19_V158_V2.5061.00
5_G179_E2.4421.00
57_Y111_E2.4181.00
123_H170_R2.2471.00
58_L66_I2.2171.00
165_K169_I2.1371.00
65_A69_Q2.1331.00
46_I49_E2.1271.00
110_N117_K2.1091.00
129_I136_E2.1081.00
152_L156_L2.0901.00
159_P162_K2.0831.00
55_K67_E2.0671.00
95_F101_A1.9891.00
169_I174_E1.9631.00
60_P64_A1.9231.00
50_I54_V1.9221.00
19_V156_L1.8661.00
17_K157_K1.8511.00
164_L167_P1.8391.00
117_K166_E1.8221.00
58_L104_A1.7801.00
50_I114_I1.7521.00
132_Y135_F1.7511.00
7_T176_W1.7221.00
46_I50_I1.7171.00
93_V101_A1.6421.00
28_A32_E1.6341.00
17_K154_K1.6261.00
53_K113_K1.6201.00
13_I127_I1.6171.00
131_K136_E1.6011.00
47_L105_I1.5991.00
45_E49_E1.5691.00
51_Y63_I1.5611.00
83_P92_F1.5531.00
48_E71_V1.5201.00
168_L176_W1.4991.00
75_D81_V1.4831.00
24_K148_P1.4711.00
50_I115_D1.4641.00
51_Y71_V1.4511.00
109_Y117_K1.4421.00
125_Y141_H1.4261.00
44_L72_Y1.4251.00
40_E171_K1.4061.00
50_I53_K1.3971.00
44_L80_L1.3691.00
62_G91_A1.3321.00
64_A68_K1.3181.00
3_Q6_D1.3131.00
35_A81_V1.3021.00
72_Y80_L1.2941.00
107_K111_E1.2891.00
21_D152_L1.2821.00
31_V101_A1.2761.00
56_P113_K1.2471.00
73_V83_P1.2451.00
16_K150_C1.2431.00
125_Y143_W1.2411.00
54_V105_I1.2371.00
60_P63_I1.2331.00
74_I80_L1.2121.00
94_I102_K1.2051.00
129_I138_V1.2011.00
94_I107_K1.1921.00
45_E48_E1.1801.00
51_Y55_K1.1781.00
46_I115_D1.1661.00
147_K150_C1.1631.00
65_A68_K1.1591.00
2_I14_L1.1521.00
19_V152_L1.1451.00
105_I114_I1.1431.00
120_I171_K1.1351.00
69_Q83_P1.1321.00
63_I67_E1.1291.00
32_E88_K1.1111.00
58_L62_G1.1051.00
96_D102_K1.1021.00
132_Y137_A1.1001.00
14_L180_L1.0941.00
129_I171_K1.0731.00
83_P91_A1.0551.00
117_K123_H1.0491.00
57_Y113_K1.0481.00
140_Y150_C1.0461.00
17_K21_D1.0391.00
44_L71_V1.0391.00
1_M11_D1.0361.00
73_V81_V1.0331.00
57_Y108_A1.0291.00
59_S62_G1.0271.00
107_K110_N1.0251.00
71_V92_F1.0251.00
102_K110_N1.0141.00
21_D24_K0.9961.00
10_S139_N0.9931.00
3_Q11_D0.9881.00
16_K142_R0.9871.00
17_K159_P0.9831.00
64_A67_E0.9821.00
41_E80_L0.9821.00
1_M8_L0.9801.00
96_D100_I0.9711.00
61_E86_N0.9691.00
69_Q73_V0.9481.00
59_S95_F0.9481.00
59_S89_E0.9401.00
4_I7_T0.9331.00
94_I104_A0.9281.00
65_A85_V0.9221.00
127_I138_V0.9181.00
2_I11_D0.9161.00
48_E72_Y0.9151.00
65_A83_P0.9111.00
3_Q8_L0.9091.00
39_L72_Y0.9081.00
65_A91_A0.9061.00
165_K174_E0.9041.00
44_L48_E0.8971.00
13_I160_V0.8921.00
47_L54_V0.8881.00
35_A75_D0.8791.00
39_L82_T0.8721.00
156_L159_P0.8691.00
9_V180_L0.8651.00
59_S93_V0.8601.00
152_L155_K0.8581.00
5_G175_E0.8491.00
12_D16_K0.8341.00
49_E115_D0.8311.00
16_K154_K0.8311.00
53_K114_I0.8301.00
129_I172_F0.8261.00
151_E154_K0.8241.00
40_E131_K0.8181.00
148_P152_L0.8181.00
144_D147_K0.8111.00
176_W180_L0.8101.00
6_D136_E0.8101.00
84_L91_A0.8091.00
94_I111_E0.8071.00
136_E171_K0.8001.00
39_L44_L0.7950.99
11_D14_L0.7950.99
21_D155_K0.7850.99
84_L93_V0.7840.99
151_E155_K0.7810.99
148_P151_E0.7780.99
50_I105_I0.7760.99
59_S94_I0.7740.99
106_E117_K0.7730.99
51_Y66_I0.7660.99
89_E95_F0.7660.99
47_L71_V0.7620.99
62_G85_V0.7610.99
61_E89_E0.7550.99
52_P56_P0.7520.99
26_K99_G0.7510.99
51_Y92_F0.7450.99
169_I178_E0.7440.99
49_E52_P0.7440.99
142_R150_C0.7440.99
162_K167_P0.7410.99
168_L172_F0.7390.99
51_Y54_V0.7330.99
14_L17_K0.7310.99
53_K56_P0.7300.99
105_I116_F0.7270.99
66_I91_A0.7240.99
41_E45_E0.7160.99
41_E44_L0.7050.99
28_A145_I0.7040.99
66_I70_G0.7000.99
22_L100_I0.6970.99
31_V93_V0.6960.99
52_P55_K0.6930.99
12_D142_R0.6910.99
75_D78_G0.6890.99
85_V88_K0.6880.99
77_D81_V0.6860.98
31_V95_F0.6850.98
54_V114_I0.6810.98
57_Y107_K0.6780.98
169_I177_Y0.6730.98
59_S63_I0.6720.98
46_I53_K0.6700.98
62_G89_E0.6630.98
85_V89_E0.6620.98
172_F176_W0.6600.98
147_K151_E0.6580.98
35_A77_D0.6540.98
102_K107_K0.6500.98
28_A148_P0.6430.98
120_I170_R0.6420.98
166_E169_I0.6360.98
103_C106_E0.6360.98
160_V164_L0.6290.97
7_T138_V0.6290.97
109_Y112_G0.6270.97
74_I78_G0.6270.97
162_K177_Y0.6210.97
138_V168_L0.6210.97
149_A160_V0.6180.97
42_E46_I0.6140.97
146_C153_G0.6140.97
158_V162_K0.6140.97
22_L102_K0.6130.97
23_S98_N0.6110.97
52_P71_V0.6100.97
144_D148_P0.6050.97
57_Y104_A0.6030.97
59_S85_V0.6010.97
28_A31_V0.6000.97
158_V163_F0.5980.96
165_K177_Y0.5980.96
125_Y145_I0.5970.96
14_L161_Y0.5970.96
97_E107_K0.5930.96
110_N113_K0.5910.96
175_E179_E0.5890.96
127_I168_L0.5840.96
130_K137_A0.5840.96
4_I179_E0.5830.96
8_L11_D0.5830.96
140_Y160_V0.5820.96
161_Y180_L0.5760.96
74_I79_D0.5760.96
48_E52_P0.5730.95
42_E45_E0.5730.95
164_L169_I0.5710.95
150_C154_K0.5660.95
7_T11_D0.5610.95
11_D15_E0.5600.95
60_P67_E0.5570.95
62_G65_A0.5560.95
23_S100_I0.5560.95
44_L92_F0.5530.95
85_V93_V0.5530.95
44_L50_I0.5520.94
84_L87_G0.5510.94
14_L160_V0.5500.94
149_A153_G0.5500.94
138_V172_F0.5450.94
75_D79_D0.5440.94
175_E178_E0.5430.94
16_K157_K0.5380.94
127_I164_L0.5360.94
35_A76_E0.5340.93
53_K57_Y0.5330.93
4_I9_V0.5320.93
95_F99_G0.5320.93
3_Q135_F0.5250.93
46_I116_F0.5210.93
65_A84_L0.5200.93
121_S128_R0.5190.92
3_Q14_L0.5180.92
82_T86_N0.5180.92
41_E72_Y0.5170.92
22_L148_P0.5130.92
19_V23_S0.5110.92
7_T129_I0.5110.92
132_Y138_V0.5100.92
35_A79_D0.5070.92
94_I99_G0.5050.91
81_V93_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lwuA 2 0.3149 8.2 0.951 Contact Map
1fzcA 1 0.2652 8.1 0.951 Contact Map
4qtqA 1 0.3591 6 0.953 Contact Map
1pm4A 3 0.2928 5.7 0.954 Contact Map
4jf3A 3 0.3149 4.6 0.956 Contact Map
1jg5A 3 0.2652 4.5 0.956 Contact Map
4ylfA 1 0.3757 3.3 0.959 Contact Map
2eboA 3 0.2707 3.3 0.959 Contact Map
2qpxA 3 0.3923 3 0.96 Contact Map
2gp4A 2 0.3646 2.8 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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