GREMLIN Database
DUF3107 - Protein of unknown function (DUF3107)
PFAM: PF11305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (73)
Sequences: 5254 (3028)
Seq/√Len: 354.4
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E49_R3.7041.00
41_W51_L2.7911.00
20_Q24_E2.4381.00
27_A31_A2.3851.00
41_W49_R2.3411.00
8_Q56_K2.2191.00
21_S24_E2.1391.00
26_E30_E2.0891.00
10_A58_A2.0671.00
24_E28_A1.9391.00
26_E41_W1.8041.00
19_D45_E1.7171.00
30_E41_W1.6271.00
29_V60_V1.5811.00
29_V40_L1.5571.00
66_E69_R1.5431.00
20_Q28_A1.4431.00
35_G38_G1.4431.00
39_V51_L1.4411.00
28_A31_A1.4191.00
16_V50_V1.3751.00
37_G55_A1.3501.00
48_R61_E1.3011.00
7_V53_P1.2981.00
9_N55_A1.2881.00
30_E34_A1.2871.00
24_E27_A1.2421.00
25_V42_L1.2191.00
31_A35_G1.1811.00
17_E45_E1.1721.00
31_A34_A1.1671.00
27_A30_E1.1561.00
9_N56_K1.1531.00
31_A36_G1.1401.00
23_D27_A1.1131.00
23_D26_E1.0541.00
13_E59_Y1.0511.00
54_A57_I1.0501.00
12_R59_Y1.0251.00
20_Q25_V1.0201.00
17_E50_V1.0141.00
34_A38_G1.0081.00
4_R13_E0.9961.00
30_E39_V0.9641.00
43_T49_R0.9511.00
8_Q58_A0.9401.00
49_R70_V0.9021.00
2_E15_V0.8761.00
32_A40_L0.8691.00
22_A26_E0.8571.00
26_E62_I0.8291.00
40_L57_I0.8281.00
32_A54_A0.7971.00
31_A38_G0.7671.00
65_P68_R0.7471.00
14_L54_A0.7451.00
26_E70_V0.7391.00
6_G59_Y0.7391.00
29_V57_I0.7351.00
57_I60_V0.7301.00
8_Q11_P0.7270.99
25_V28_A0.7090.99
2_E63_G0.7060.99
64_A70_V0.6940.99
36_G55_A0.6890.99
64_A68_R0.6890.99
4_R56_K0.6880.99
5_I52_V0.6870.99
34_A37_G0.6750.99
7_V52_V0.6600.99
11_P19_D0.6370.99
23_D49_R0.6280.99
48_R64_A0.6240.98
5_I57_I0.6210.98
22_A25_V0.6200.98
33_L54_A0.6160.98
44_D48_R0.6160.98
18_S45_E0.6150.98
50_V73_G0.6140.98
46_K66_E0.6090.98
18_S42_L0.6070.98
53_P58_A0.6050.98
22_A49_R0.6000.98
12_R68_R0.5990.98
68_R73_G0.5970.98
40_L52_V0.5940.98
44_D62_I0.5860.98
66_E70_V0.5770.97
7_V10_A0.5630.97
61_E68_R0.5600.97
9_N58_A0.5590.97
28_A40_L0.5570.97
9_N64_A0.5560.97
33_L39_V0.5540.97
21_S65_P0.5500.97
22_A65_P0.5470.97
18_S21_S0.5470.97
16_V63_G0.5410.96
50_V53_P0.5370.96
10_A56_K0.5360.96
4_R15_V0.5340.96
2_E17_E0.5340.96
29_V62_I0.5220.95
7_V58_A0.5180.95
3_V7_V0.5120.95
45_E70_V0.5100.95
20_Q43_T0.5050.95
27_A34_A0.5040.95
17_E53_P0.5000.94
4_R61_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3oA 1 0.6301 19.9 0.879 Contact Map
1wfxA 3 0.7671 9.2 0.896 Contact Map
4wtvA 1 0.7945 9 0.896 Contact Map
1vpzA 2 0.3836 8.7 0.897 Contact Map
4lkbF 4 0.8082 7.1 0.901 Contact Map
2y9jY 3 0.8082 6.9 0.901 Contact Map
4yl8A 1 1 6.7 0.902 Contact Map
2i1jA 3 1 6.4 0.903 Contact Map
4w4mA 1 0.7671 6.3 0.903 Contact Map
2wgkA 2 0.9863 6.1 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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