GREMLIN Database
DUF3106 - Protein of unknown function (DUF3106)
PFAM: PF11304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (102)
Sequences: 10394 (7055)
Seq/√Len: 698.6
META: 0.962

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_E101_Q2.9781.00
23_P26_R2.9521.00
5_S8_Q2.6531.00
59_T62_Q2.6081.00
95_P98_E2.5931.00
77_P80_E2.5211.00
41_P44_E2.4311.00
8_Q31_L2.1351.00
37_W45_R2.1151.00
87_A90_R1.9471.00
32_E35_Q1.9391.00
53_E57_K1.9161.00
62_Q65_Q1.7991.00
6_P9_Q1.7551.00
35_Q39_S1.6881.00
7_E10_Q1.6441.00
80_E83_R1.6351.00
18_R21_S1.6041.00
54_R57_K1.5721.00
40_M48_L1.5191.00
26_R29_R1.4991.00
64_Q68_E1.4891.00
90_R93_A1.4851.00
70_F74_R1.4641.00
34_A38_P1.4601.00
36_R40_M1.4431.00
88_W91_Y1.3681.00
55_W67_R1.3151.00
13_A16_A1.3011.00
96_P99_R1.2931.00
16_A20_D1.2761.00
87_A91_Y1.2571.00
61_E64_Q1.2471.00
72_R75_Q1.2461.00
42_P45_R1.2431.00
19_W27_Q1.2331.00
10_Q13_A1.2181.00
37_W49_Q1.2151.00
44_E47_R1.1901.00
36_R39_S1.1881.00
46_Q50_E1.1841.00
78_P81_R1.1821.00
82_Q86_Q1.1631.00
28_Q32_E1.1571.00
69_R72_R1.1471.00
86_Q89_R1.0911.00
30_L52_M1.0711.00
29_R32_E1.0651.00
65_Q69_R1.0631.00
27_Q31_L1.0411.00
83_R87_A1.0411.00
30_L33_R1.0361.00
62_Q66_A1.0321.00
65_Q68_E1.0231.00
22_L27_Q1.0211.00
89_R93_A1.0171.00
96_P100_Q1.0071.00
1_W16_A1.0031.00
71_Q75_Q0.9961.00
68_E72_R0.9901.00
1_W5_S0.9891.00
29_R33_R0.9641.00
24_P28_Q0.9601.00
51_R54_R0.9591.00
43_E46_Q0.9591.00
44_E48_L0.9571.00
68_E71_Q0.9351.00
47_R51_R0.9241.00
50_E53_E0.9231.00
66_A70_F0.9221.00
66_A69_R0.8981.00
81_R85_R0.8831.00
19_W37_W0.8831.00
82_Q85_R0.8821.00
55_W63_R0.8751.00
91_Y94_L0.8571.00
74_R81_R0.8551.00
84_L87_A0.8521.00
90_R94_L0.8361.00
58_L66_A0.8291.00
24_P27_Q0.8231.00
9_Q16_A0.8101.00
15_L19_W0.8071.00
45_R49_Q0.7931.00
33_R36_R0.7921.00
86_Q90_R0.7851.00
9_Q13_A0.7821.00
52_M56_A0.7671.00
89_R92_Q0.7631.00
8_Q35_Q0.7611.00
35_Q38_P0.7611.00
6_P10_Q0.7211.00
73_F81_R0.7131.00
28_Q31_L0.7081.00
37_W48_L0.7041.00
88_W92_Q0.7001.00
22_L30_L0.6921.00
30_L34_A0.6901.00
50_E54_R0.6831.00
94_L98_E0.6801.00
19_W34_A0.6681.00
73_F76_L0.6661.00
47_R50_E0.6611.00
1_W12_L0.6601.00
83_R86_Q0.6451.00
40_M45_R0.6411.00
11_V14_P0.6381.00
26_R30_L0.6371.00
31_L34_A0.6261.00
67_R70_F0.6231.00
61_E65_Q0.6221.00
94_L102_L0.6131.00
33_R48_L0.6091.00
55_W66_A0.6081.00
42_P46_Q0.6061.00
25_E28_Q0.6051.00
54_R58_L0.6001.00
91_Y95_P0.5971.00
40_M44_E0.5931.00
48_L51_R0.5911.00
97_E101_Q0.5771.00
37_W52_M0.5771.00
46_Q49_Q0.5761.00
8_Q11_V0.5681.00
34_A70_F0.5651.00
49_Q53_E0.5651.00
63_R67_R0.5551.00
64_Q67_R0.5541.00
85_R88_W0.5541.00
14_P17_P0.5531.00
97_E100_Q0.5531.00
93_A101_Q0.5521.00
55_W70_F0.5491.00
73_F77_P0.5421.00
53_E56_A0.5361.00
27_Q30_L0.5291.00
23_P30_L0.5281.00
11_V19_W0.5271.00
75_Q78_P0.5261.00
69_R73_F0.5251.00
55_W74_R0.5231.00
48_L52_M0.5231.00
57_K60_P0.5221.00
33_R52_M0.5211.00
15_L22_L0.5171.00
55_W69_R0.5110.99
11_V15_L0.5100.99
37_W56_A0.5070.99
85_R89_R0.5040.99
5_S10_Q0.5020.99
49_Q52_M0.5020.99
58_L62_Q0.5000.99
17_P20_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w9yA 1 0.9135 83.9 0.751 Contact Map
4mncA 1 0.7596 51.8 0.804 Contact Map
1j7nA 2 0.7019 47.8 0.808 Contact Map
2ouxA 2 0.8269 46.9 0.81 Contact Map
4wwfA 2 0.9038 45.7 0.811 Contact Map
2zy9A 2 0.7981 42.8 0.814 Contact Map
3u65B 1 0.7596 40 0.817 Contact Map
3oeoA 3 0.7981 37.5 0.82 Contact Map
3o39A 2 0.7981 37.1 0.821 Contact Map
3zg1A 2 0.9135 35.6 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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