GREMLIN Database
DUF3105 - Protein of unknown function (DUF3105)
PFAM: PF11303 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (118)
Sequences: 9794 (6421)
Seq/√Len: 591.1
META: 0.913

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_L111_I3.0581.00
27_C49_A2.7261.00
99_R118_Y2.6481.00
59_P62_D2.3371.00
38_D85_Y2.3001.00
31_V82_L2.2581.00
53_T95_T2.1871.00
101_L110_R2.1111.00
60_A64_A2.0991.00
21_Y40_N1.9841.00
43_H47_H1.9621.00
115_I119_R1.9371.00
53_T83_S1.8521.00
62_D65_A1.8471.00
21_Y39_E1.8221.00
37_P40_N1.7941.00
70_V82_L1.7601.00
13_N85_Y1.7471.00
89_D102_K1.7451.00
20_H46_E1.7101.00
31_V67_K1.6971.00
16_T100_Q1.6111.00
69_L112_R1.5761.00
93_A102_K1.5511.00
90_S102_K1.5471.00
43_H46_E1.5301.00
66_L82_L1.5081.00
25_A36_V1.4681.00
64_A68_A1.4681.00
112_R116_D1.4631.00
56_P59_P1.4621.00
41_A53_T1.4581.00
25_A44_N1.4311.00
95_T100_Q1.4221.00
64_A67_K1.4171.00
44_N81_L1.3671.00
122_G125_P1.3521.00
108_D112_R1.3511.00
41_A81_L1.3511.00
41_A51_V1.3471.00
113_A117_A1.3311.00
67_K71_D1.3041.00
90_S104_D1.3011.00
50_V96_A1.2931.00
55_N91_P1.2931.00
58_L62_D1.2791.00
15_P38_D1.2781.00
35_P86_P1.2331.00
96_A114_F1.2231.00
93_A100_Q1.2101.00
94_L101_L1.2001.00
36_V41_A1.1921.00
13_N38_D1.1701.00
6_T21_Y1.1601.00
33_D67_K1.1431.00
103_L110_R1.1371.00
60_A63_V1.1321.00
61_A65_A1.1081.00
12_T16_T1.0771.00
12_T100_Q1.0741.00
21_Y37_P1.0661.00
51_V83_S1.0641.00
25_A40_N1.0481.00
53_T88_L1.0431.00
72_E112_R1.0201.00
88_L93_A1.0131.00
44_N49_A1.0051.00
96_A118_Y0.9941.00
110_R113_A0.9871.00
38_D41_A0.9831.00
20_H47_H0.9771.00
41_A83_S0.9741.00
10_Y39_E0.9631.00
109_P113_A0.9531.00
77_Q119_R0.9461.00
41_A95_T0.9351.00
27_C44_N0.9191.00
118_Y121_K0.9011.00
31_V70_V0.8921.00
80_V119_R0.8761.00
58_L63_V0.8681.00
13_N89_D0.8631.00
88_L91_P0.8611.00
63_V67_K0.8591.00
47_H124_E0.8551.00
62_D91_P0.8531.00
17_S98_G0.8351.00
80_V115_I0.8321.00
50_V115_I0.8251.00
8_V19_P0.8241.00
107_D110_R0.8231.00
69_L106_F0.8171.00
106_F111_I0.7981.00
113_A116_D0.7821.00
94_L103_L0.7741.00
72_E108_D0.7741.00
65_A106_F0.7741.00
65_A108_D0.7731.00
91_P104_D0.7651.00
24_W40_N0.7641.00
121_K125_P0.7631.00
52_I94_L0.7611.00
13_N87_G0.7601.00
36_V40_N0.7451.00
8_V39_E0.7431.00
38_D87_G0.7411.00
56_P86_P0.7181.00
24_W47_H0.7161.00
52_I80_V0.7141.00
52_I69_L0.7041.00
90_S93_A0.6951.00
23_V40_N0.6911.00
43_H124_E0.6871.00
45_L51_V0.6771.00
7_P39_E0.6751.00
20_H43_H0.6751.00
53_T85_Y0.6621.00
25_A81_L0.6601.00
55_N58_L0.6581.00
12_T19_P0.6561.00
120_G125_P0.6561.00
52_I115_I0.6541.00
59_P63_V0.6511.00
36_V83_S0.6511.00
92_I105_S0.6491.00
46_E124_E0.6311.00
79_Y119_R0.6271.00
12_T98_G0.6201.00
70_V80_V0.6021.00
35_P84_P0.5961.00
42_V45_L0.5891.00
85_Y88_L0.5851.00
21_Y24_W0.5851.00
100_Q103_L0.5841.00
16_T95_T0.5741.00
61_A64_A0.5741.00
66_L69_L0.5691.00
25_A32_Y0.5661.00
51_V81_L0.5641.00
119_R122_G0.5631.00
24_W27_C0.5611.00
65_A68_A0.5580.99
49_A81_L0.5540.99
54_Y63_V0.5520.99
69_L73_L0.5500.99
51_V95_T0.5500.99
103_L111_I0.5440.99
11_N17_S0.5420.99
73_L119_R0.5420.99
79_Y120_G0.5420.99
69_L111_I0.5410.99
80_V85_Y0.5400.99
73_L76_G0.5390.99
34_E84_P0.5370.99
58_L91_P0.5360.99
56_P91_P0.5340.99
65_A107_D0.5310.99
68_A71_D0.5300.99
52_I70_V0.5300.99
54_Y84_P0.5280.99
73_L115_I0.5230.99
92_I111_I0.5220.99
65_A69_L0.5220.99
23_V26_N0.5200.99
96_A99_R0.5160.99
62_D106_F0.5130.99
80_V84_P0.5130.99
14_P85_Y0.5120.99
22_P40_N0.5110.99
63_V66_L0.5110.99
88_L102_K0.5100.99
66_L92_I0.5070.99
67_K82_L0.5050.99
99_R119_R0.5040.99
63_V70_V0.5030.99
52_I92_I0.5020.99
55_N89_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkxL 1 0.5906 13.9 0.928 Contact Map
1cvrA 1 0.5591 7.6 0.936 Contact Map
2ru8A 1 0.378 7.5 0.936 Contact Map
3o39A 2 0.5197 5.4 0.94 Contact Map
4g0oA 1 0.3465 5.2 0.94 Contact Map
4g0xA 1 0.3465 4.9 0.941 Contact Map
2v8tA 5 0.4016 4.8 0.941 Contact Map
1yviA 1 0.4252 4.5 0.942 Contact Map
2a1xA 1 0.6929 4.5 0.942 Contact Map
2fctA 1 0.7165 4.1 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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