GREMLIN Database
DUF3099 - Protein of unknown function (DUF3099)
PFAM: PF11298 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (70)
Sequences: 3651 (1905)
Seq/√Len: 227.7
META: 0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R18_R3.2511.00
21_L25_G2.5581.00
30_C52_G2.4911.00
13_I17_Q2.2901.00
33_L49_L2.2731.00
37_V49_L2.1671.00
7_R15_R2.0341.00
9_L13_I1.9861.00
7_R11_E1.8901.00
34_A50_V1.7721.00
15_R19_R1.6591.00
43_G47_W1.4801.00
24_M60_A1.4721.00
17_Q21_L1.4711.00
18_R21_L1.4441.00
19_R63_I1.4241.00
33_L36_V1.4041.00
31_F53_A1.3791.00
22_I26_I1.3781.00
18_R22_I1.3671.00
44_W48_V1.3611.00
8_S11_E1.3571.00
23_S28_T1.3531.00
14_R17_Q1.3171.00
58_Y62_V1.3091.00
42_P46_A1.2941.00
37_V42_P1.2901.00
59_V62_V1.2801.00
50_V54_V1.2131.00
33_L37_V1.1971.00
42_P45_L1.1591.00
34_A46_A1.1571.00
7_R12_D1.1331.00
28_T32_V1.0781.00
41_H46_A1.0751.00
23_S59_V1.0691.00
34_A49_L1.0571.00
12_D15_R0.9541.00
55_V59_V0.9431.00
11_E15_R0.9381.00
10_S13_I0.9321.00
62_V66_A0.9261.00
30_C53_A0.9211.00
25_G29_V0.9151.00
37_V46_A0.9090.99
26_I30_C0.9010.99
45_L48_V0.9010.99
6_P12_D0.8770.99
22_I25_G0.8540.99
1_L47_W0.8150.99
29_V53_A0.8040.99
37_V43_G0.8030.99
37_V41_H0.7900.99
66_A69_P0.7790.98
1_L58_Y0.7770.98
63_I66_A0.7740.98
11_E17_Q0.7640.98
9_L12_D0.7580.98
61_V64_A0.7550.98
48_V52_G0.7500.98
47_W51_V0.7470.98
26_I52_G0.7430.98
52_G56_L0.7260.98
63_I69_P0.7150.97
53_A58_Y0.7140.97
19_R23_S0.7130.97
29_V55_V0.7090.97
32_V36_V0.7040.97
51_V55_V0.7030.97
41_H45_L0.7000.97
1_L5_A0.6850.96
66_A70_R0.6810.96
2_I13_I0.6740.96
23_S56_L0.6620.96
1_L23_S0.6470.95
27_R61_V0.6470.95
28_T31_F0.6430.95
31_F54_V0.6410.95
10_S14_R0.6210.94
27_R30_C0.6090.93
2_I5_A0.6050.93
43_G53_A0.6030.93
38_Y41_H0.5990.93
46_A50_V0.5930.92
9_L68_R0.5900.92
56_L59_V0.5890.92
24_M57_P0.5880.92
15_R63_I0.5850.92
37_V45_L0.5790.92
29_V33_L0.5740.91
23_S60_A0.5690.91
61_V65_N0.5660.91
35_V46_A0.5570.90
49_L52_G0.5500.89
25_G28_T0.5370.88
37_V40_V0.5350.88
19_R32_V0.5340.88
4_S9_L0.5310.88
59_V63_I0.5300.88
21_L28_T0.5290.87
35_V50_V0.5250.87
43_G46_A0.5100.85
6_P10_S0.5080.85
27_R57_P0.5040.85
54_V58_Y0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 1 12.6 0.883 Contact Map
4umwA 1 1 7.3 0.895 Contact Map
4f4cA 1 1 7.1 0.895 Contact Map
3zdqA 2 1 6.6 0.897 Contact Map
4ry2A 2 1 6.4 0.898 Contact Map
4q9hA 1 0.9028 6.4 0.898 Contact Map
3b5xA 2 1 5.6 0.901 Contact Map
3j09A 2 0.9722 5 0.903 Contact Map
4a82A 2 1 4.8 0.904 Contact Map
4q4hB 1 1 4.6 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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