GREMLIN Database
DUF3098 - Protein of unknown function (DUF3098)
PFAM: PF11297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (66)
Sequences: 6907 (3363)
Seq/√Len: 413.9
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_F47_L3.6281.00
13_G59_E2.9901.00
5_E65_K2.4911.00
31_D34_V2.3371.00
16_V58_I2.2431.00
11_L15_A2.1511.00
4_K8_I2.0131.00
5_E8_I1.7581.00
13_G58_I1.6881.00
23_L51_L1.6231.00
8_I12_I1.6151.00
46_T50_I1.5371.00
42_F46_T1.5351.00
17_I21_F1.4111.00
15_A19_L1.4091.00
24_M52_I1.4091.00
16_V54_A1.4021.00
22_I25_S1.3781.00
50_I54_A1.3261.00
59_E62_A1.2811.00
17_I56_F1.2641.00
53_L57_V1.2631.00
10_M59_E1.2581.00
21_F52_I1.2341.00
10_M62_A1.2271.00
54_A58_I1.1921.00
61_Y65_K1.1851.00
38_E41_S1.1731.00
9_L65_K1.1681.00
9_L58_I1.1561.00
16_V51_L1.1511.00
56_F59_E1.1461.00
26_G44_R1.1051.00
29_S35_F1.0591.00
5_E9_L1.0371.00
57_V61_Y1.0361.00
41_S45_I1.0211.00
3_G65_K1.0151.00
60_I64_M1.0141.00
58_I61_Y1.0011.00
48_A52_I0.9661.00
29_S34_V0.9651.00
41_S44_R0.9601.00
1_A40_F0.9541.00
17_I59_E0.9521.00
43_R47_L0.9241.00
21_F64_M0.8851.00
29_S38_E0.8741.00
30_D38_E0.8661.00
8_I11_L0.8381.00
1_A4_K0.8221.00
19_L22_I0.7951.00
9_L12_I0.7851.00
24_M45_I0.7641.00
9_L62_A0.7411.00
11_L14_L0.7281.00
34_V37_P0.7261.00
14_L18_I0.7221.00
30_D34_V0.7101.00
12_I15_A0.7091.00
2_F7_Y0.6901.00
29_S36_N0.6761.00
27_G30_D0.6751.00
44_R48_A0.6610.99
2_F10_M0.6510.99
33_N37_P0.6400.99
2_F6_N0.6350.99
20_G52_I0.6300.99
18_I22_I0.6280.99
23_L43_R0.6240.99
17_I52_I0.6150.99
27_G43_R0.6120.99
40_F44_R0.5930.99
54_A57_V0.5890.99
3_G6_N0.5870.99
36_N39_I0.5870.99
40_F45_I0.5800.99
6_N62_A0.5800.99
12_I58_I0.5710.98
21_F56_F0.5680.98
19_L23_L0.5590.98
30_D33_N0.5590.98
29_S40_F0.5520.98
12_I16_V0.5440.98
35_F39_I0.5330.97
19_L51_L0.5300.97
12_I19_L0.5290.97
13_G62_A0.5290.97
19_L47_L0.5280.97
27_G41_S0.5240.97
26_G43_R0.5220.97
24_M48_A0.5200.97
9_L61_Y0.5170.97
5_E61_Y0.5160.97
3_G7_Y0.5120.97
35_F38_E0.5090.97
55_G62_A0.5070.97
51_L59_E0.5030.96
37_P40_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gsmB 1 1 7.4 0.891 Contact Map
2mmuA 1 0.3881 6.6 0.893 Contact Map
3hb3B 1 1 6.4 0.894 Contact Map
3ixzA 1 0.8955 5.6 0.897 Contact Map
2zxeA 1 0.8955 5.6 0.897 Contact Map
3b5dA 2 0.4179 5.4 0.897 Contact Map
3ayfA 2 0.9403 4.1 0.903 Contact Map
4phuA 1 0.4179 3.7 0.905 Contact Map
2yevB 1 1 3.6 0.906 Contact Map
3mk7A 1 0.9104 3.5 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.004 seconds.