GREMLIN Database
DUF3093 - Protein of unknown function (DUF3093)
PFAM: PF11292 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (139)
Sequences: 3023 (2089)
Seq/√Len: 177.2
META: 0.767

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_A111_A3.9361.00
90_A95_D3.5541.00
132_R135_E3.3081.00
64_E71_R3.1191.00
59_E66_R2.7511.00
73_P76_Y2.7501.00
3_R57_R2.4661.00
90_A94_P2.4031.00
72_I77_L2.3721.00
84_D87_A2.3331.00
100_A125_Y2.2411.00
78_G116_V2.1291.00
91_A95_D1.9981.00
72_I116_V1.9881.00
81_E115_E1.9341.00
67_A128_V1.9001.00
3_R59_E1.8931.00
81_E113_R1.7001.00
118_D121_D1.6921.00
92_R104_L1.6801.00
56_P103_L1.6751.00
78_G117_D1.6701.00
25_L29_P1.6591.00
78_G115_E1.6181.00
79_E115_E1.5911.00
67_A103_L1.5491.00
65_L128_V1.5271.00
80_V115_E1.5191.00
108_I129_S1.4831.00
80_V137_A1.4671.00
15_L19_L1.4121.00
26_V29_P1.4061.00
91_A113_R1.3911.00
111_A130_T1.3781.00
82_A137_A1.3731.00
56_P67_A1.3661.00
65_L114_V1.3631.00
83_L111_A1.3291.00
58_I128_V1.3281.00
91_A96_A1.3011.00
88_A92_R1.2941.00
86_E89_R1.2861.00
23_A26_V1.2721.00
31_G36_L1.2591.00
66_R71_R1.2321.00
33_G37_V1.2311.00
34_A38_V1.2251.00
64_E74_L1.2141.00
24_A27_A1.2091.00
8_V12_W1.2041.00
70_A101_F1.1961.00
85_A109_K1.1841.00
135_E138_A1.1841.00
31_G34_A1.1671.00
32_L35_A1.1551.00
9_P12_W1.1431.00
32_L36_L1.1381.00
25_L28_A1.1181.00
24_A28_A1.0951.00
82_A130_T1.0951.00
134_E138_A1.0951.00
118_D123_T1.0831.00
61_T64_E1.0661.00
48_A52_W1.0330.99
28_A32_L1.0250.99
72_I76_Y1.0120.99
13_W21_L1.0100.99
58_I65_L1.0090.99
29_P32_L1.0060.99
84_D134_E0.9910.99
30_V34_A0.9860.99
70_A121_D0.9830.99
23_A27_A0.9820.99
61_T66_R0.9800.99
74_L77_L0.9790.99
77_L80_V0.9710.99
81_E87_A0.9480.99
96_A111_A0.9450.99
31_G37_V0.9440.99
128_V136_L0.9370.99
74_L140_L0.9350.99
87_A95_D0.9330.99
88_A104_L0.9290.99
76_Y117_D0.9270.99
56_P105_R0.9210.99
31_G35_A0.9180.99
83_L91_A0.9150.99
23_A29_P0.9040.99
31_G38_V0.8920.98
45_L49_L0.8920.98
27_A35_A0.8890.98
46_A50_L0.8770.98
30_V36_L0.8750.98
22_S26_V0.8680.98
10_L14_L0.8680.98
27_A31_G0.8630.98
85_A110_T0.8440.98
92_R127_L0.8400.98
83_L88_A0.8390.98
26_V31_G0.8340.98
87_A90_A0.8230.97
27_A33_G0.8230.97
111_A127_L0.8200.97
27_A32_L0.8190.97
49_L53_L0.8190.97
130_T133_P0.8190.97
27_A30_V0.8140.97
25_L31_G0.8080.97
22_S25_L0.8080.97
61_T74_L0.8010.97
60_V139_A0.7980.97
70_A118_D0.7970.97
70_A123_T0.7960.97
60_V136_L0.7930.97
30_V35_A0.7900.97
97_D124_P0.7740.96
13_W16_A0.7720.96
24_A31_G0.7700.96
114_V128_V0.7640.96
135_E139_A0.7590.96
25_L34_A0.7590.96
88_A127_L0.7500.96
118_D122_P0.7460.95
10_L107_W0.7430.95
85_A88_A0.7360.95
133_P139_A0.7360.95
23_A28_A0.7340.95
76_Y116_V0.7340.95
113_R123_T0.7290.95
33_G38_V0.7250.95
20_A43_L0.7220.95
63_G74_L0.7120.94
82_A112_V0.7020.94
83_L96_A0.6960.93
32_L38_V0.6960.93
28_A35_A0.6950.93
15_L18_L0.6940.93
84_D96_A0.6840.93
54_G107_W0.6790.93
96_A102_L0.6780.93
101_F123_T0.6690.92
2_Y132_R0.6670.92
14_L18_L0.6620.92
11_W14_L0.6590.92
44_A48_A0.6460.91
72_I80_V0.6280.89
23_A31_G0.6280.89
76_Y123_T0.6280.89
12_W83_L0.6260.89
15_L21_L0.6220.89
40_A44_A0.6210.89
28_A31_G0.6190.89
20_A24_A0.6170.89
18_L21_L0.6130.88
65_L136_L0.6110.88
24_A29_P0.6070.88
97_D125_Y0.6030.87
75_S117_D0.6000.87
70_A122_P0.5990.87
19_L22_S0.5980.87
133_P138_A0.5910.86
96_A125_Y0.5890.86
12_W16_A0.5870.86
29_P37_V0.5850.86
30_V33_G0.5830.86
114_V137_A0.5820.86
21_L24_A0.5810.86
8_V50_L0.5740.85
58_I67_A0.5640.84
82_A106_P0.5620.84
116_V123_T0.5570.83
62_D74_L0.5560.83
52_W55_R0.5550.83
64_E73_P0.5540.83
26_V32_L0.5540.83
80_V114_V0.5530.83
26_V30_V0.5530.83
102_L107_W0.5490.82
25_L38_V0.5480.82
88_A110_T0.5470.82
40_A43_L0.5470.82
113_R127_L0.5470.82
39_Y42_L0.5450.82
50_L54_G0.5450.82
92_R111_A0.5430.81
30_V38_V0.5390.81
35_A39_Y0.5380.81
28_A38_V0.5340.80
73_P116_V0.5320.80
29_P33_G0.5310.80
100_A124_P0.5300.80
32_L37_V0.5290.80
67_A97_D0.5280.80
14_L120_A0.5270.80
29_P35_A0.5210.79
65_L77_L0.5160.78
90_A134_E0.5130.78
20_A44_A0.5130.78
136_L139_A0.5110.77
92_R102_L0.5100.77
89_R94_P0.5100.77
76_Y79_E0.5100.77
104_L129_S0.5050.77
2_Y60_V0.5020.76
77_L116_V0.5020.76
133_P137_A0.5010.76
25_L33_G0.5000.76
8_V15_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ynfA 2 0.2929 14.7 0.935 Contact Map
4c5eA 3 0.4 8.6 0.942 Contact Map
3ut1A 2 0.3786 8.4 0.942 Contact Map
3f70A 2 0.4214 8.3 0.942 Contact Map
1oz2A 1 0.3857 7.2 0.944 Contact Map
2bivA 1 0.4 6.7 0.944 Contact Map
3pmiA 4 0.2571 6.3 0.945 Contact Map
2jlnA 1 0.4714 5.4 0.947 Contact Map
1bxnI 3 0.4429 5.2 0.947 Contact Map
2r58A 1 0.3786 4.2 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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