GREMLIN Database
DUF3090 - Protein of unknown function (DUF3090)
PFAM: PF11290 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (168)
Sequences: 4792 (3042)
Seq/√Len: 234.7
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_D136_R3.7971.00
35_V88_V3.5391.00
134_L139_A3.4191.00
16_E19_Q3.2051.00
3_F33_V3.0881.00
36_A87_R3.0201.00
11_A42_V2.9411.00
21_T36_A2.9361.00
91_L106_A2.7871.00
27_R79_E2.7051.00
42_V146_A2.6541.00
8_R79_E2.6141.00
108_E128_D2.1961.00
156_P164_L2.1781.00
40_Q43_A2.0681.00
37_L42_V2.0611.00
89_G109_L2.0441.00
28_Q31_R2.0361.00
26_A132_V2.0051.00
27_R32_V1.9731.00
9_F142_F1.9611.00
49_L139_A1.9521.00
35_V130_L1.9301.00
4_D99_R1.9021.00
88_V106_A1.8771.00
50_E147_A1.8681.00
94_G103_V1.8641.00
7_D28_Q1.8631.00
135_T138_Q1.8271.00
9_F134_L1.8211.00
143_A147_A1.7091.00
78_L82_V1.6771.00
110_V127_P1.6251.00
142_F146_A1.5811.00
165_D168_G1.5171.00
115_D118_E1.4851.00
157_C160_C1.4731.00
46_A146_A1.4641.00
102_V139_A1.4611.00
11_A146_A1.4541.00
95_Y100_D1.4541.00
2_E131_R1.4411.00
90_T107_Q1.4201.00
78_L81_P1.4081.00
47_E147_A1.3871.00
6_P9_F1.3701.00
43_A150_V1.3621.00
10_T76_M1.3561.00
6_P28_Q1.3081.00
92_G107_Q1.3061.00
49_L143_A1.2951.00
52_L102_V1.2561.00
92_G131_R1.2561.00
144_R147_A1.2381.00
95_Y136_R1.2301.00
18_G39_K1.2141.00
36_A84_P1.2091.00
37_L88_V1.1981.00
50_E143_A1.1891.00
5_P101_R1.1771.00
107_Q129_V1.1741.00
23_Y36_A1.1521.00
24_L142_F1.1221.00
99_R133_R1.1051.00
7_D29_G1.0541.00
33_V130_L1.0521.00
119_D122_D1.0441.00
145_R149_V1.0361.00
96_D99_R1.0331.00
149_V152_A1.0331.00
72_L75_D1.0271.00
74_D77_P1.0101.00
26_A35_V1.0091.00
55_E59_R1.0081.00
5_P28_Q0.9961.00
80_E83_E0.9881.00
159_L170_F0.9751.00
54_D140_R0.9691.00
85_E130_L0.9651.00
6_P132_V0.9631.00
49_L134_L0.9601.00
24_L106_A0.9451.00
23_Y82_V0.9431.00
7_D27_R0.9431.00
25_Q34_S0.9411.00
18_G22_F0.9311.00
13_T42_V0.9261.00
35_V106_A0.9181.00
26_A130_L0.9031.00
89_G108_E0.9031.00
49_L102_V0.9011.00
13_T16_E0.8980.99
62_A65_P0.8910.99
164_L167_E0.8800.99
40_Q107_Q0.8780.99
44_A48_R0.8760.99
12_G23_Y0.8710.99
40_Q44_A0.8680.99
158_P161_G0.8590.99
31_R85_E0.8590.99
46_A150_V0.8570.99
19_Q167_E0.8560.99
119_D127_P0.8490.99
119_D126_G0.8460.99
55_E58_R0.8400.99
147_A151_A0.8370.99
11_A142_F0.8350.99
63_E66_A0.8310.99
53_L136_R0.8300.99
12_G25_Q0.8300.99
122_D126_G0.8300.99
32_V79_E0.8260.99
60_G63_E0.8210.99
50_E144_R0.8170.99
77_P145_R0.8090.99
101_R135_T0.8090.99
73_E144_R0.7960.99
45_L91_L0.7870.99
114_E118_E0.7850.99
21_T87_R0.7790.99
162_Q170_F0.7770.99
15_G18_G0.7770.99
57_A60_G0.7770.99
86_F130_L0.7740.99
23_Y84_P0.7740.99
166_P169_H0.7730.98
110_V113_E0.7690.98
57_A66_A0.7610.98
12_G77_P0.7550.98
26_A33_V0.7520.98
48_R93_L0.7510.98
84_P87_R0.7470.98
124_P127_P0.7450.98
25_Q81_P0.7420.98
105_E131_R0.7400.98
15_G20_R0.7390.98
56_L95_Y0.7370.98
33_V132_V0.7360.98
61_G65_P0.7360.98
94_G107_Q0.7300.98
143_A150_V0.7300.98
48_R51_E0.7290.98
42_V150_V0.7250.98
4_D133_R0.7230.98
74_D145_R0.7210.98
39_K153_G0.7190.98
78_L132_V0.7180.98
6_P138_Q0.7160.98
158_P164_L0.7150.98
10_T25_Q0.7110.97
115_D119_D0.7090.97
148_E151_A0.7070.97
69_P72_L0.7020.97
32_V82_V0.7010.97
34_S82_V0.6980.97
139_A142_F0.6970.97
23_Y81_P0.6960.97
14_V23_Y0.6910.97
58_R61_G0.6890.97
10_T145_R0.6830.97
40_Q48_R0.6820.97
144_R148_E0.6780.97
35_V85_E0.6750.96
85_E159_L0.6730.96
25_Q32_V0.6730.96
97_E100_D0.6720.96
17_P20_R0.6710.96
103_V133_R0.6670.96
44_A47_E0.6650.96
159_L164_L0.6620.96
164_L168_G0.6600.96
34_S84_P0.6570.96
44_A51_E0.6550.96
37_L142_F0.6530.96
118_E123_D0.6520.96
93_L140_R0.6490.96
46_A147_A0.6460.95
9_F146_A0.6460.95
65_P68_A0.6440.95
156_P159_L0.6440.95
101_R133_R0.6400.95
8_R27_R0.6370.95
147_A152_A0.6360.95
63_E144_R0.6340.95
134_L138_Q0.6340.95
17_P169_H0.6330.95
39_K154_R0.6270.95
110_V114_E0.6260.95
43_A47_E0.6200.94
139_A143_A0.6190.94
62_A66_A0.6140.94
94_G133_R0.6090.94
161_G170_F0.6090.94
15_G22_F0.6080.94
91_L107_Q0.6040.94
13_T21_T0.5990.93
71_P137_A0.5970.93
119_D123_D0.5950.93
9_F132_V0.5930.93
81_P84_P0.5900.93
47_E51_E0.5890.93
121_D126_G0.5870.93
3_F6_P0.5860.93
111_E125_E0.5860.93
25_Q78_L0.5850.92
79_E82_V0.5820.92
112_E118_E0.5820.92
48_R90_T0.5800.92
80_E85_E0.5790.92
156_P161_G0.5790.92
158_P170_F0.5770.92
4_D28_Q0.5750.92
138_Q141_A0.5720.92
3_F26_A0.5670.91
3_F28_Q0.5670.91
17_P22_F0.5670.91
108_E127_P0.5630.91
7_D30_G0.5590.91
41_Q92_G0.5560.90
92_G105_E0.5540.90
24_L37_L0.5510.90
115_D121_D0.5500.90
65_P69_P0.5440.90
113_E123_D0.5440.90
18_G153_G0.5430.89
112_E126_G0.5420.89
38_E154_R0.5400.89
33_V85_E0.5400.89
35_V132_V0.5380.89
52_L93_L0.5340.89
38_E153_G0.5330.89
160_C171_C0.5330.89
133_R148_E0.5290.88
73_E76_M0.5260.88
41_Q91_L0.5240.88
50_E140_R0.5240.88
123_D126_G0.5200.87
150_V153_G0.5190.87
70_D144_R0.5190.87
11_A149_V0.5180.87
93_L159_L0.5180.87
75_D78_L0.5120.87
86_F128_D0.5110.86
53_L140_R0.5080.86
46_A50_E0.5080.86
21_T84_P0.5070.86
120_P123_D0.5070.86
156_P162_Q0.5060.86
14_V21_T0.5060.86
88_V105_E0.5020.85
6_P134_L0.5010.85
14_V82_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r6fA 2 0.6667 45.7 0.933 Contact Map
1l8dA 2 0.3743 40.3 0.935 Contact Map
3zqjA 1 0.6784 38.2 0.936 Contact Map
3m86A 4 0.3216 19.8 0.944 Contact Map
4h9dA 3 0.3041 17.8 0.945 Contact Map
3pihA 2 0.6257 16.6 0.946 Contact Map
2h7wA 1 0.3216 16 0.946 Contact Map
2e1vA 1 0.2982 15.4 0.947 Contact Map
4gxbA 1 0.345 15.4 0.947 Contact Map
2c34A 1 0.3333 15.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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