GREMLIN Database
DUF3087 - Protein of unknown function (DUF3087)
PFAM: PF11286 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 165 (165)
Sequences: 560 (360)
Seq/√Len: 28.0
META: 0.532

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_F53_L3.8791.00
10_R14_H3.4781.00
106_G151_L3.1951.00
89_L120_G3.1121.00
111_M148_M3.0821.00
88_S160_F3.0031.00
18_V79_V2.8841.00
12_R16_R2.6440.99
100_K140_E2.3740.99
117_Y121_L2.3500.99
29_L59_G2.3440.99
93_T96_M2.2250.98
26_L30_S2.1620.98
16_R19_T2.1460.98
80_V84_Q2.1360.98
42_G48_N1.9180.95
17_R75_W1.8890.95
91_R165_L1.8220.94
103_V111_M1.8090.94
141_I145_D1.7870.93
117_Y160_F1.7390.92
12_R15_L1.7340.92
147_R153_L1.7280.92
147_R151_L1.6830.91
121_L137_L1.6590.90
122_R141_I1.6370.90
137_L144_L1.6080.89
106_G150_A1.5930.88
89_L124_L1.5820.88
73_H76_M1.5780.88
31_L35_T1.5770.88
12_R19_T1.5330.86
106_G147_R1.5300.86
1_M8_K1.4760.84
93_T125_Y1.4660.84
111_M144_L1.4630.84
124_L132_L1.4350.82
35_T42_G1.4220.82
24_A61_L1.4120.81
53_L57_I1.3940.80
143_E161_D1.3750.80
90_N94_R1.3660.79
4_Q36_L1.3550.79
93_T133_T1.3390.78
92_I116_F1.3340.77
6_I78_E1.3290.77
142_D146_E1.3130.76
49_F57_I1.3120.76
25_I59_G1.2920.75
146_E150_A1.2350.72
29_L33_L1.2290.71
157_Q164_W1.2240.71
24_A28_V1.2000.69
148_M153_L1.1990.69
42_G51_L1.1950.69
101_A149_E1.1660.67
96_M99_V1.1590.67
99_V114_L1.1530.66
103_V114_L1.1400.65
37_L51_L1.1380.65
66_L70_L1.1340.65
138_V142_D1.1330.65
89_L121_L1.1150.64
50_R54_L1.1130.63
96_M114_L1.1050.63
70_L76_M1.0990.62
53_L100_K1.0980.62
34_S89_L1.0760.61
107_D159_R1.0730.61
54_L59_G1.0550.59
97_H101_A1.0250.57
140_E143_E1.0170.56
159_R164_W1.0170.56
135_S142_D1.0150.56
61_L65_A1.0150.56
26_L31_L1.0150.56
61_L75_W1.0140.56
121_L124_L1.0050.56
35_T48_N1.0040.55
85_L120_G1.0020.55
63_T121_L1.0020.55
154_D157_Q0.9920.55
96_M113_I0.9910.54
4_Q77_A0.9800.54
131_T134_L0.9740.53
99_V113_I0.9740.53
15_L90_N0.9590.52
84_Q87_Q0.9550.52
133_T153_L0.9530.52
38_I49_F0.9450.51
34_S37_L0.9410.51
43_E47_S0.9390.50
19_T23_A0.9360.50
25_I116_F0.9320.50
97_H102_A0.9260.49
91_R162_P0.9250.49
120_G124_L0.9220.49
108_P146_E0.9220.49
16_R116_F0.9170.49
76_M115_R0.9070.48
152_G161_D0.8990.47
136_E140_E0.8980.47
148_M155_L0.8950.47
115_R157_Q0.8940.47
2_Q28_V0.8930.47
109_D165_L0.8920.47
106_G153_L0.8890.47
145_D155_L0.8820.46
8_K129_D0.8820.46
9_E13_K0.8730.45
13_K28_V0.8690.45
125_Y133_T0.8690.45
87_Q91_R0.8670.45
28_V57_I0.8660.45
63_T120_G0.8650.45
131_T144_L0.8590.44
108_P143_E0.8590.44
26_L40_L0.8580.44
20_L133_T0.8560.44
36_L96_M0.8540.44
99_V145_D0.8540.44
121_L160_F0.8450.43
104_E147_R0.8430.43
60_L73_H0.8430.43
51_L59_G0.8420.43
52_N56_V0.8390.43
76_M141_I0.8380.43
146_E149_E0.8380.43
36_L100_K0.8370.43
71_K87_Q0.8350.43
18_V21_I0.8340.42
122_R138_V0.8340.42
49_F56_V0.8330.42
75_W84_Q0.8280.42
100_K147_R0.8190.41
29_L114_L0.8190.41
137_L141_I0.8140.41
4_Q54_L0.8080.41
12_R96_M0.8040.40
19_T60_L0.8010.40
37_L100_K0.7930.39
51_L122_R0.7900.39
53_L75_W0.7830.39
28_V149_E0.7780.38
87_Q94_R0.7580.37
41_F65_A0.7570.37
11_Y92_I0.7560.37
76_M124_L0.7540.37
135_S139_R0.7420.36
88_S132_L0.7390.36
132_L137_L0.7370.35
89_L137_L0.7260.35
109_D154_D0.7250.35
1_M90_N0.7240.34
78_E113_I0.7240.34
62_L155_L0.7210.34
40_L64_A0.7200.34
48_N56_V0.7160.34
83_W87_Q0.7160.34
22_I48_N0.7140.34
33_L58_L0.7100.34
11_Y82_V0.7100.34
37_L58_L0.7060.33
41_F109_D0.7050.33
113_I160_F0.7020.33
121_L125_Y0.7000.33
142_D145_D0.7000.33
132_L136_E0.6990.33
126_Q134_L0.6970.33
67_L80_V0.6970.33
36_L39_A0.6940.32
13_K30_S0.6820.32
103_V144_L0.6760.31
31_L91_R0.6670.31
46_G58_L0.6660.31
135_S138_V0.6590.30
114_L117_Y0.6500.30
57_I160_F0.6470.29
100_K109_D0.6450.29
75_W112_K0.6430.29
29_L42_G0.6420.29
2_Q153_L0.6410.29
72_T134_L0.6400.29
2_Q159_R0.6390.29
3_L78_E0.6370.29
23_A128_D0.6340.29
71_K80_V0.6330.28
36_L163_A0.6320.28
21_I87_Q0.6240.28
6_I129_D0.6240.28
23_A30_S0.6230.28
16_R34_S0.6220.28
103_V147_R0.6210.28
129_D132_L0.6200.28
35_T39_A0.6140.27
94_R133_T0.6130.27
87_Q124_L0.6110.27
10_R158_D0.6030.27
103_V115_R0.6000.26
112_K164_W0.6000.26
32_L35_T0.5970.26
19_T67_L0.5960.26
142_D149_E0.5940.26
112_K125_Y0.5940.26
74_P78_E0.5910.26
3_L148_M0.5910.26
114_L143_E0.5890.26
19_T22_I0.5880.26
139_R155_L0.5810.25
6_I71_K0.5790.25
68_R162_P0.5780.25
27_A32_L0.5750.25
74_P80_V0.5690.25
65_A69_K0.5670.25
26_L71_K0.5610.24
13_K17_R0.5600.24
95_K111_M0.5590.24
96_M115_R0.5550.24
108_P153_L0.5530.24
14_H78_E0.5520.24
34_S120_G0.5500.24
28_V36_L0.5460.23
120_G152_G0.5440.23
16_R22_I0.5420.23
84_Q111_M0.5420.23
37_L49_F0.5370.23
97_H116_F0.5370.23
82_V94_R0.5350.23
125_Y129_D0.5340.23
26_L38_I0.5320.23
95_K99_V0.5300.22
6_I121_L0.5290.22
1_M6_I0.5280.22
22_I42_G0.5250.22
1_M82_V0.5230.22
76_M85_L0.5220.22
154_D158_D0.5200.22
64_A72_T0.5200.22
27_A85_L0.5180.22
84_Q124_L0.5170.22
114_L140_E0.5170.22
15_L19_T0.5150.22
119_L164_W0.5110.21
63_T100_K0.5050.21
99_V157_Q0.5020.21
69_K108_P0.5010.21
57_I61_L0.5000.21
139_R142_D0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qq0A 1 0.5152 60.9 0.94 Contact Map
2m8rA 1 0.2545 32.8 0.95 Contact Map
4n9nA 2 0.6364 25.5 0.952 Contact Map
4djkA 2 0.497 25 0.952 Contact Map
3ixzA 1 0.4788 18 0.956 Contact Map
2c9kA 1 0.7818 17.8 0.956 Contact Map
4xmmE 1 0.5394 16 0.957 Contact Map
1ji6A 1 0.7636 15.1 0.957 Contact Map
3pjsK 4 0.6545 14.5 0.957 Contact Map
2zxeA 1 0.4788 13.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.