GREMLIN Database
DUF3084 - Protein of unknown function (DUF3084)
PFAM: PF11283 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (75)
Sequences: 1229 (767)
Seq/√Len: 88.6
META: 0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_G54_A3.3061.00
36_L44_L2.8881.00
8_L54_A2.5601.00
70_T75_L2.4731.00
62_L72_L2.1401.00
70_T74_G1.9961.00
24_R28_K1.8151.00
13_G47_V1.7741.00
68_V75_L1.5481.00
3_L7_A1.5341.00
13_G51_M1.4971.00
72_L75_L1.4881.00
8_L58_L1.4700.99
64_V67_D1.4530.99
67_D76_E1.4340.99
21_R24_R1.4270.99
65_S68_V1.4130.99
66_E70_T1.3860.99
14_L18_L1.3750.99
26_V45_I1.3700.99
21_R25_K1.3700.99
25_K28_K1.3590.99
12_G28_K1.3510.99
18_L22_L1.3490.99
42_A46_T1.3350.99
62_L68_V1.2890.99
3_L33_L1.2750.99
27_G41_T1.2720.98
48_L52_L1.2490.98
43_I47_V1.2460.98
19_G49_T1.2300.98
11_L15_I1.1900.98
40_H43_I1.1720.97
62_L75_L1.1170.97
24_R42_A1.1030.96
65_S69_R1.0750.96
62_L66_E1.0690.96
70_T73_F1.0600.95
49_T53_I1.0550.95
17_Y32_S1.0450.95
39_R43_I1.0360.95
16_A47_V1.0290.95
17_Y21_R1.0270.94
62_L73_F1.0170.94
33_L44_L0.9980.94
59_G63_L0.9890.93
24_R40_H0.9720.93
17_Y47_V0.9600.92
65_S70_T0.9490.92
45_I49_T0.9230.91
36_L40_H0.8920.89
31_L45_I0.8750.88
29_K68_V0.8750.88
20_D30_R0.8470.86
71_A75_L0.8430.86
31_L42_A0.8010.83
61_L64_V0.7950.83
60_V64_V0.7950.83
7_A11_L0.7930.83
63_L69_R0.7880.82
14_L51_M0.7740.81
23_G30_R0.7740.81
66_E69_R0.7640.80
19_G58_L0.7630.80
18_L53_I0.7590.80
58_L71_A0.7580.80
57_T61_L0.7570.80
11_L18_L0.7490.79
49_T54_A0.7450.79
20_D24_R0.7380.78
30_R42_A0.7370.78
49_T73_F0.7080.75
70_T76_E0.7060.75
25_K40_H0.7030.74
24_R43_I0.6990.74
45_I63_L0.6980.74
25_K29_K0.6880.73
19_G45_I0.6810.72
21_R42_A0.6780.72
54_A57_T0.6780.72
26_V39_R0.6750.71
20_D25_K0.6730.71
4_L19_G0.6680.71
4_L11_L0.6680.71
4_L33_L0.6610.70
10_L15_I0.6540.69
47_V57_T0.6420.68
6_L9_V0.6350.67
22_L25_K0.6270.66
43_I48_L0.6260.66
12_G21_R0.6110.64
17_Y29_K0.6100.64
43_I46_T0.6030.63
17_Y35_G0.6020.63
33_L59_G0.5780.60
40_H46_T0.5750.59
36_L41_T0.5730.59
21_R39_R0.5670.58
10_L70_T0.5620.57
11_L72_L0.5600.57
28_K74_G0.5570.57
35_G48_L0.5560.57
39_R58_L0.5500.56
45_I51_M0.5340.54
45_I48_L0.5230.52
67_D71_A0.5210.52
53_I57_T0.5210.52
20_D39_R0.5180.51
40_H76_E0.5160.51
57_T73_F0.5140.51
67_D75_L0.5070.50
57_T74_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 1 40.6 0.876 Contact Map
4oh3A 2 0.8961 12.7 0.903 Contact Map
4gipD 3 0.3896 10.6 0.906 Contact Map
3tuiA 2 0.3636 8.3 0.91 Contact Map
3kfwX 4 0.5325 7.2 0.913 Contact Map
4zw9A 1 0.987 5.9 0.916 Contact Map
2cfqA 1 0.987 5.6 0.917 Contact Map
4gc0A 1 0.9481 4.5 0.921 Contact Map
4j05A 3 1 4.4 0.921 Contact Map
3o7qA 1 0.987 4 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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