GREMLIN Database
DUF3082 - Protein of unknown function (DUF3082)
PFAM: PF11282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (78)
Sequences: 560 (370)
Seq/√Len: 41.9
META: 0.668

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_F67_F3.2901.00
7_L76_G3.2131.00
10_A73_F2.8231.00
18_W22_L2.8061.00
28_A55_V2.3891.00
19_L22_L2.3351.00
14_G69_A1.9010.99
22_L26_S1.8080.98
74_L77_I1.7070.97
56_G60_L1.6760.97
43_A47_A1.5430.95
15_G19_L1.5360.95
59_F63_F1.5140.95
41_P45_N1.4870.94
27_I58_S1.4770.94
24_T59_F1.4240.93
52_T64_V1.3300.90
5_R8_S1.3240.89
45_N48_S1.3190.89
38_S44_Q1.3080.89
29_A33_L1.3030.89
23_L54_V1.2670.87
10_A14_G1.2570.87
9_G65_F1.2520.87
49_A52_T1.2470.86
75_L78_Q1.2420.86
17_A66_G1.2190.85
25_Q58_S1.2080.85
7_L66_G1.1910.84
13_S68_I1.1820.83
11_L15_G1.1770.83
24_T61_A1.1440.81
17_A62_T1.1120.79
50_V54_V1.1050.79
2_G5_R1.0870.78
17_A55_V1.0580.76
3_P16_L1.0430.75
69_A78_Q1.0350.74
20_L64_V1.0010.72
18_W70_L0.9940.71
58_S61_A0.9910.71
2_G6_C0.9740.70
17_A29_A0.9740.70
16_L20_L0.9710.69
9_G20_L0.9690.69
46_I50_V0.9640.69
52_T56_G0.9500.68
73_F77_I0.9400.67
23_L53_L0.9320.66
3_P7_L0.9240.65
8_S77_I0.9190.65
13_S69_A0.9100.64
18_W73_F0.8950.63
22_L25_Q0.8890.62
17_A40_N0.8840.62
46_I53_L0.8820.62
31_F54_V0.8810.62
2_G8_S0.8750.61
25_Q34_H0.8720.61
11_L39_D0.8710.61
75_L79_L0.8690.61
26_S29_A0.8680.60
38_S43_A0.8550.59
46_I49_A0.8340.57
20_L54_V0.8230.56
30_Y34_H0.8170.56
27_I33_L0.8120.55
25_Q73_F0.8050.55
6_C76_G0.7970.54
42_I68_I0.7810.52
10_A69_A0.7740.52
13_S23_L0.7710.52
31_F48_S0.7530.50
19_L48_S0.7500.50
11_L76_G0.7320.48
26_S54_V0.7290.48
31_F47_A0.7180.47
17_A49_A0.7150.46
27_I50_V0.7100.46
24_T58_S0.6940.44
68_I78_Q0.6940.44
24_T55_V0.6900.44
32_A55_V0.6820.43
12_T17_A0.6770.43
26_S70_L0.6650.42
26_S37_H0.6610.41
24_T35_P0.6590.41
74_L78_Q0.6580.41
54_V60_L0.6490.40
39_D73_F0.6460.40
29_A73_F0.6310.39
36_I39_D0.6240.38
15_G57_L0.6140.37
35_P50_V0.6140.37
59_F66_G0.6120.37
10_A54_V0.6040.36
17_A65_F0.6020.36
64_V78_Q0.5890.35
28_A32_A0.5800.34
20_L62_T0.5480.32
16_L42_I0.5470.31
25_Q48_S0.5460.31
26_S33_L0.5460.31
2_G16_L0.5320.30
22_L77_I0.5310.30
45_N64_V0.5300.30
29_A44_Q0.5280.30
7_L15_G0.5270.30
15_G18_W0.5210.29
2_G18_W0.5200.29
45_N49_A0.5180.29
3_P10_A0.5150.29
36_I48_S0.5150.29
25_Q29_A0.5110.29
7_L73_F0.5080.28
47_A50_V0.5020.28
4_L68_I0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b2hA 3 0.825 23.2 0.873 Contact Map
3hd6A 3 0.8125 14.3 0.885 Contact Map
1u7gA 3 0.825 13 0.887 Contact Map
3b9wA 3 0.7625 9.3 0.894 Contact Map
4av3A 2 0.8875 4.9 0.907 Contact Map
4a01A 2 0.8625 3.8 0.911 Contact Map
3l1lA 2 0.4625 2.4 0.92 Contact Map
4m5bA 1 0.975 2.3 0.921 Contact Map
4rfsS 1 0.425 2.2 0.922 Contact Map
2m3eA 1 0.525 1.8 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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