GREMLIN Database
DUF3080 - Protein of unknown function (DUF3080)
PFAM: PF11279 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 316 (313)
Sequences: 581 (502)
Seq/√Len: 28.3
META: 0.527

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_S177_E6.0501.00
83_F87_L5.4411.00
75_Q177_E4.7911.00
211_E300_R4.1611.00
239_Y302_V3.9801.00
80_E118_V3.1191.00
230_I233_N3.0781.00
3_D242_E2.9891.00
199_L250_L2.9401.00
63_R80_E2.8781.00
177_E180_L2.8661.00
47_D103_T2.8581.00
87_L107_A2.8091.00
76_R80_E2.6771.00
235_F305_W2.5790.99
181_Q185_K2.4580.99
235_F246_Y2.4180.99
207_T235_F2.4030.99
207_T304_A2.3380.99
83_F107_A2.2990.99
7_R244_Q2.2190.98
193_L290_L2.2000.98
52_R57_Q2.1730.98
74_S180_L2.1500.98
65_S70_V2.0430.97
75_Q78_L2.0270.97
59_L79_Y1.9730.96
299_R303_Q1.9360.96
251_D295_R1.9330.96
196_L250_L1.9170.96
126_S129_W1.8810.95
239_Y246_Y1.8670.95
7_R233_N1.8630.95
172_D175_E1.8200.94
72_D177_E1.8050.94
62_E82_R1.7960.94
28_L133_F1.7200.92
195_S246_Y1.7070.92
10_R238_F1.7060.92
234_V237_K1.7040.92
80_E111_K1.6750.91
39_P114_Q1.6720.91
220_P225_T1.6720.91
309_L316_P1.6600.91
279_Y282_Y1.6380.90
3_D10_R1.6330.90
207_T300_R1.6110.89
196_L294_F1.6060.89
13_D105_Q1.6020.89
44_G69_K1.5750.88
87_L108_L1.5720.88
77_L122_A1.5670.88
221_N225_T1.5660.88
7_R234_V1.5630.88
128_E184_R1.5420.87
305_W312_C1.5400.87
206_A209_L1.5300.87
48_F132_F1.5240.86
301_H312_C1.5230.86
7_R306_Q1.4990.85
34_L130_R1.4950.85
6_Q10_R1.4430.83
275_L278_Y1.4420.83
238_F242_E1.4420.83
74_S128_E1.4380.83
49_L57_Q1.4220.82
234_V238_F1.4200.82
3_D7_R1.4170.82
235_F239_Y1.4170.82
214_L311_Q1.4160.82
114_Q118_V1.3870.81
217_R311_Q1.3770.80
133_F261_L1.3690.80
173_S218_L1.3640.79
115_L192_L1.3440.78
200_T207_T1.3320.78
252_R307_Q1.3300.78
204_N297_A1.3210.77
207_T297_A1.3110.77
7_R238_F1.3060.76
18_E26_P1.3010.76
113_Q277_P1.2930.76
58_Q61_A1.2810.75
74_S78_L1.2720.74
136_S139_L1.2700.74
202_W254_Y1.2630.74
31_R130_R1.2620.74
76_R118_V1.2580.74
71_A75_Q1.2530.73
132_F190_G1.2500.73
251_D255_Q1.2470.73
10_R230_I1.2470.73
156_A179_H1.2460.73
203_L297_A1.2440.73
291_W295_R1.2410.72
8_L12_L1.2370.72
120_W272_P1.2360.72
11_V133_F1.2290.72
3_D6_Q1.2290.72
145_D250_L1.2220.71
57_Q61_A1.2200.71
232_R236_Q1.2160.71
5_L206_A1.2150.71
213_R311_Q1.2120.71
51_L61_A1.2070.70
51_L71_A1.2010.70
48_F57_Q1.1990.70
31_R127_E1.1960.70
4_Y45_L1.1900.69
128_E206_A1.1900.69
24_P41_L1.1880.69
84_L108_L1.1730.68
204_N293_Q1.1600.67
308_L313_G1.1570.67
181_Q184_R1.1550.67
155_A243_V1.1380.66
66_S256_Q1.1360.66
4_Y301_H1.1340.65
42_R48_F1.1340.65
306_Q312_C1.1330.65
7_R10_R1.1260.65
146_T149_E1.1250.65
84_L87_L1.1230.65
298_T302_V1.1190.64
72_D75_Q1.1180.64
41_L110_Q1.1170.64
11_V231_L1.1000.63
89_A106_E1.1000.63
244_Q248_A1.0990.63
250_L259_P1.0880.62
69_K206_A1.0710.61
80_E122_A1.0700.61
59_L82_R1.0700.61
69_K233_N1.0670.61
81_L85_R1.0610.60
18_E262_Q1.0550.60
210_L214_L1.0480.59
43_I100_L1.0420.59
156_A159_Q1.0390.59
48_F61_A1.0390.59
112_R261_L1.0380.58
7_R11_V1.0370.58
42_R80_E1.0370.58
34_L71_A1.0370.58
80_E116_P1.0310.58
123_L182_T1.0300.58
230_I234_V1.0290.58
235_F309_L1.0270.58
188_L253_R1.0260.58
199_L247_L1.0250.57
304_A309_L1.0230.57
183_L234_V1.0200.57
149_E152_Q1.0080.56
61_A100_L1.0010.56
30_R123_L1.0010.56
79_Y305_W0.9970.55
69_K266_Q0.9940.55
199_L294_F0.9900.55
65_S73_P0.9900.55
203_L291_W0.9840.54
8_L209_L0.9820.54
163_R166_D0.9770.54
53_G57_Q0.9740.54
38_I114_Q0.9710.53
36_L157_L0.9680.53
192_L254_Y0.9620.53
10_R244_Q0.9600.52
60_I290_L0.9590.52
228_A309_L0.9590.52
153_A156_A0.9580.52
24_P36_L0.9550.52
230_I309_L0.9510.52
157_L183_L0.9480.52
117_A154_L0.9460.51
254_Y291_W0.9450.51
178_Q250_L0.9430.51
80_E246_Y0.9410.51
105_Q113_Q0.9390.51
163_R168_D0.9380.51
11_V32_R0.9360.51
42_R257_L0.9310.50
57_Q180_L0.9300.50
196_L254_Y0.9290.50
83_F123_L0.9270.50
233_N244_Q0.9270.50
120_W190_G0.9260.50
4_Y8_L0.9250.50
132_F189_G0.9240.50
123_L129_W0.9210.49
10_R309_L0.9140.49
235_F306_Q0.9140.49
81_L115_L0.9110.49
196_L298_T0.9100.49
309_L314_L0.9090.49
8_L207_T0.9080.48
243_V255_Q0.9060.48
78_L173_S0.9060.48
78_L176_L0.9040.48
245_P305_W0.9030.48
8_L206_A0.9020.48
66_S70_V0.9010.48
78_L177_E0.8980.48
91_L105_Q0.8980.48
131_Q187_R0.8970.48
36_L113_Q0.8960.48
239_Y247_L0.8890.47
77_L119_F0.8880.47
84_L165_L0.8720.46
233_N248_A0.8700.46
275_L279_Y0.8700.46
19_P205_Q0.8640.45
70_V246_Y0.8620.45
63_R69_K0.8590.45
3_D238_F0.8540.44
12_L308_L0.8520.44
69_K111_K0.8510.44
272_P278_Y0.8500.44
5_L190_G0.8460.44
276_Q279_Y0.8440.44
43_I48_F0.8430.44
91_L101_A0.8430.44
166_D262_Q0.8430.44
180_L184_R0.8430.44
233_N237_K0.8430.44
38_I121_N0.8350.43
49_L52_R0.8320.43
256_Q259_P0.8300.43
99_E161_V0.8240.42
130_R133_F0.8210.42
239_Y305_W0.8190.42
94_E310_K0.8180.42
188_L192_L0.8150.41
277_P303_Q0.8130.41
21_P99_E0.8080.41
136_S191_Q0.8070.41
107_A294_F0.8070.41
272_P276_Q0.8020.40
48_F128_E0.7980.40
139_L194_R0.7950.40
128_E189_G0.7940.40
288_D307_Q0.7940.40
294_F305_W0.7920.40
190_G313_G0.7900.40
56_L103_T0.7850.39
56_L77_L0.7850.39
234_V244_Q0.7820.39
71_A130_R0.7810.39
11_V233_N0.7800.39
124_L239_Y0.7780.39
243_V315_S0.7750.38
29_P120_W0.7750.38
69_K114_Q0.7740.38
125_A190_G0.7710.38
50_S80_E0.7660.38
21_P102_A0.7650.38
308_L311_Q0.7650.38
152_Q156_A0.7630.38
222_G302_V0.7600.37
43_I298_T0.7570.37
243_V252_R0.7570.37
100_L283_L0.7560.37
92_L288_D0.7560.37
226_P230_I0.7540.37
150_L261_L0.7530.37
218_L311_Q0.7480.36
26_P206_A0.7450.36
272_P275_L0.7410.36
38_I118_V0.7410.36
30_R241_G0.7400.36
37_P99_E0.7370.36
47_D100_L0.7370.36
49_L126_S0.7360.36
109_Q208_A0.7340.35
247_L298_T0.7340.35
228_A314_L0.7330.35
264_L303_Q0.7320.35
82_R183_L0.7310.35
107_A183_L0.7300.35
225_T229_R0.7280.35
93_P98_E0.7270.35
36_L117_A0.7260.35
6_Q60_I0.7260.35
123_L268_L0.7220.35
52_R61_A0.7220.35
45_L100_L0.7190.34
203_L206_A0.7190.34
6_Q238_F0.7180.34
41_L157_L0.7160.34
129_W180_L0.7160.34
160_L188_L0.7130.34
121_N235_F0.7120.34
244_Q302_V0.7120.34
204_N296_Q0.7090.34
34_L291_W0.7050.33
47_D161_V0.7030.33
268_L272_P0.7020.33
242_E245_P0.7010.33
97_D198_L0.7010.33
71_A133_F0.7000.33
100_L103_T0.6960.33
46_L63_R0.6960.33
78_L180_L0.6940.33
41_L49_L0.6940.33
54_C68_G0.6930.33
115_L119_F0.6900.32
54_C64_N0.6880.32
4_Y7_R0.6880.32
119_F268_L0.6860.32
277_P296_Q0.6860.32
239_Y251_D0.6850.32
13_D156_A0.6820.32
71_A190_G0.6750.31
63_R76_R0.6750.31
11_V244_Q0.6740.31
104_L210_L0.6730.31
207_T211_E0.6720.31
94_E101_A0.6700.31
49_L311_Q0.6690.31
121_N231_L0.6680.31
11_V18_E0.6670.31
76_R161_V0.6660.31
219_C312_C0.6640.31
10_R235_F0.6640.31
2_D243_V0.6620.31
188_L298_T0.6570.30
104_L157_L0.6540.30
61_A64_N0.6530.30
3_D20_S0.6530.30
183_L232_R0.6530.30
82_R165_L0.6520.30
77_L87_L0.6510.30
41_L239_Y0.6500.30
227_R230_I0.6490.30
41_L195_S0.6490.30
60_I111_K0.6480.30
69_K218_L0.6470.30
32_R181_Q0.6450.29
12_L214_L0.6450.29
111_K231_L0.6430.29
98_E102_A0.6400.29
235_F253_R0.6400.29
47_D226_P0.6380.29
214_L304_A0.6370.29
127_E215_A0.6360.29
230_I244_Q0.6340.29
201_A205_Q0.6320.29
65_S190_G0.6310.29
222_G225_T0.6280.28
72_D127_E0.6280.28
278_Y282_Y0.6270.28
22_P25_L0.6270.28
199_L202_W0.6250.28
64_N68_G0.6250.28
129_W133_F0.6240.28
80_E132_F0.6230.28
88_P99_E0.6220.28
53_G61_A0.6220.28
70_V220_P0.6220.28
226_P229_R0.6200.28
61_A121_N0.6200.28
50_S190_G0.6190.28
27_R33_E0.6180.28
9_A108_L0.6160.28
149_E185_K0.6150.28
153_A197_A0.6150.28
110_Q266_Q0.6110.27
249_Q253_R0.6100.27
11_V243_V0.6100.27
112_R158_N0.6090.27
15_E18_E0.6090.27
52_R308_L0.6040.27
37_P109_Q0.6040.27
64_N244_Q0.6030.27
53_G239_Y0.6020.27
65_S125_A0.6020.27
176_L255_Q0.5950.26
287_R291_W0.5950.26
46_L72_D0.5950.26
192_L250_L0.5940.26
265_E268_L0.5940.26
147_S156_A0.5930.26
109_Q300_R0.5920.26
70_V79_Y0.5920.26
130_R239_Y0.5920.26
102_A280_Q0.5920.26
25_L135_L0.5900.26
162_Q289_S0.5890.26
9_A262_Q0.5890.26
96_E102_A0.5860.26
84_L107_A0.5860.26
64_N69_K0.5840.26
12_L209_L0.5840.26
228_A316_P0.5840.26
66_S261_L0.5830.26
61_A254_Y0.5830.26
133_F305_W0.5820.26
217_R226_P0.5800.25
50_S196_L0.5800.25
28_L36_L0.5780.25
76_R142_Y0.5780.25
124_L190_G0.5760.25
65_S189_G0.5750.25
142_Y265_E0.5750.25
40_E204_N0.5730.25
90_C219_C0.5720.25
55_E58_Q0.5700.25
83_F210_L0.5660.25
235_F244_Q0.5640.25
241_G256_Q0.5640.25
192_L253_R0.5640.25
62_E79_Y0.5630.24
224_P314_L0.5610.24
136_S166_D0.5600.24
164_W167_G0.5590.24
8_L179_H0.5560.24
54_C90_C0.5560.24
220_P252_R0.5520.24
231_L305_W0.5510.24
9_A109_Q0.5500.24
30_R113_Q0.5500.24
233_N238_F0.5500.24
79_Y245_P0.5470.24
126_S196_L0.5470.24
51_L246_Y0.5470.24
28_L56_L0.5450.23
49_L193_L0.5430.23
28_L134_S0.5420.23
222_G316_P0.5410.23
183_L250_L0.5400.23
50_S61_A0.5400.23
147_S150_L0.5390.23
150_L296_Q0.5390.23
46_L100_L0.5380.23
151_L243_V0.5370.23
239_Y290_L0.5360.23
143_P191_Q0.5360.23
58_Q248_A0.5360.23
80_E133_F0.5340.23
104_L203_L0.5340.23
10_R233_N0.5310.23
102_A205_Q0.5290.23
69_K246_Y0.5250.22
112_R125_A0.5230.22
3_D149_E0.5230.22
24_P293_Q0.5220.22
59_L305_W0.5220.22
60_I108_L0.5210.22
10_R234_V0.5190.22
97_D284_S0.5170.22
13_D280_Q0.5160.22
76_R177_E0.5150.22
65_S234_V0.5150.22
110_Q195_S0.5140.22
102_A116_P0.5130.22
119_F133_F0.5130.22
39_P118_V0.5110.22
29_P34_L0.5090.22
88_P108_L0.5070.21
19_P152_Q0.5060.21
21_P252_R0.5060.21
72_D183_L0.5050.21
120_W125_A0.5050.21
65_S111_K0.5020.21
45_L184_R0.5020.21
48_F80_E0.5000.21
120_W278_Y0.5000.21
229_R314_L0.5000.21
17_P162_Q0.5000.21
60_I138_G0.5000.21
4_Y46_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hiuA 3 0.212 29.7 0.961 Contact Map
1uptB 2 0.1867 18 0.965 Contact Map
2gyqA 2 0.2342 17.8 0.965 Contact Map
3oghB 2 0.2215 11.4 0.968 Contact Map
2gs4A 5 0.212 9.7 0.969 Contact Map
4yifA 2 0.1013 7.3 0.97 Contact Map
3fmpB 1 0 6.9 0.971 Contact Map
2ozbB 1 0.3418 5.8 0.972 Contact Map
3fhtA 1 0.1487 5.6 0.972 Contact Map
4etrA 1 0.1962 5.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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