GREMLIN Database
DUF3079 - Protein of unknown function (DUF3079)
PFAM: PF11278 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (50)
Sequences: 1031 (335)
Seq/√Len: 47.4
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K29_A4.8251.00
35_I38_Q3.9131.00
11_H14_R3.0691.00
28_L37_T2.5061.00
8_H46_D1.6810.98
5_F34_S1.4890.96
33_G37_T1.4650.95
36_R41_V1.3950.94
35_I44_F1.3850.94
8_H41_V1.3730.93
16_C19_C1.3650.93
3_K37_T1.3640.93
22_Y37_T1.3190.92
44_F51_W1.3110.92
35_I43_L1.2930.91
33_G38_Q1.1970.88
45_G48_W1.1750.87
36_R49_L1.1560.86
3_K6_P1.1210.84
8_H38_Q1.0900.82
18_G36_R1.0580.80
24_P29_A1.0440.79
41_V47_D1.0160.77
34_S43_L1.0040.77
14_R17_W0.9900.76
7_L20_D0.9810.75
24_P43_L0.9730.74
10_K35_I0.9230.70
18_G39_H0.9100.69
41_V46_D0.9090.69
20_D41_V0.9010.68
10_K28_L0.8900.68
15_I26_D0.8730.66
7_L26_D0.8660.65
44_F49_L0.8430.63
15_I25_A0.8340.62
31_G38_Q0.8180.61
14_R19_C0.7980.59
13_E16_C0.7940.59
7_L49_L0.7850.58
12_P28_L0.7770.57
15_I24_P0.7700.56
9_P23_C0.7450.54
34_S37_T0.7440.54
9_P48_W0.7280.52
11_H15_I0.6950.49
38_Q43_L0.6920.49
16_C39_H0.6840.48
22_Y31_G0.6820.48
8_H44_F0.6600.45
12_P36_R0.6520.45
11_H19_C0.6460.44
13_E30_C0.6440.44
6_P41_V0.6390.43
29_A38_Q0.6340.43
37_T44_F0.6240.42
12_P17_W0.6230.42
4_K11_H0.6150.41
29_A35_I0.5630.36
27_D31_G0.5600.36
21_K26_D0.5560.35
3_K15_I0.5460.35
30_C36_R0.5460.35
26_D41_V0.5430.34
2_A8_H0.5410.34
31_G37_T0.5340.33
23_C48_W0.5340.33
17_W39_H0.5290.33
42_E47_D0.5250.33
26_D50_E0.5220.32
40_P48_W0.5170.32
32_N38_Q0.5130.32
3_K22_Y0.5110.31
20_D43_L0.5050.31
20_D49_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gqiA 2 0.3333 6.9 0.921 Contact Map
1j3gA 1 0.6863 4.3 0.928 Contact Map
4uquA 2 0.9216 4.1 0.929 Contact Map
2hw2A 1 0.5686 3.6 0.93 Contact Map
3nzpA 2 0.9804 2.9 0.934 Contact Map
4knkA 1 0.902 2.5 0.936 Contact Map
2i1sA 1 0.9412 2.3 0.938 Contact Map
4ivvA 1 0.902 2.1 0.939 Contact Map
3m97X 1 0.2157 2.1 0.939 Contact Map
4r43A 1 0.9216 2 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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