GREMLIN Database
DUF3078 - Protein of unknown function (DUF3078)
PFAM: PF11276 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (91)
Sequences: 9780 (6093)
Seq/√Len: 638.7
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_F69_Y4.6611.00
44_Y90_A3.0861.00
73_A79_Y2.5321.00
43_A60_D2.4791.00
36_W67_S2.1981.00
42_L89_F2.0691.00
33_K71_Y2.0361.00
28_N37_D1.9291.00
38_N67_S1.8841.00
64_D84_N1.8791.00
30_K72_K1.6521.00
24_N41_D1.6171.00
34_F71_Y1.6111.00
35_S78_Y1.5951.00
64_D86_R1.5671.00
46_L56_F1.5081.00
72_K78_Y1.4981.00
42_L63_I1.4581.00
26_F39_S1.4461.00
74_S77_W1.4401.00
41_D62_R1.4161.00
52_Q57_R1.3121.00
20_N60_D1.3051.00
63_I87_T1.2891.00
31_K34_F1.2881.00
43_A62_R1.2571.00
58_K61_D1.2481.00
30_K35_S1.2391.00
47_V59_T1.2251.00
40_L65_L1.2181.00
29_Y34_F1.1911.00
14_E49_Q1.1851.00
61_D89_F1.1771.00
58_K88_Q1.1501.00
66_N84_N1.1301.00
69_Y81_A1.1211.00
37_D68_K1.1111.00
6_F13_G1.1011.00
49_Q52_Q1.0991.00
48_K55_G1.0821.00
1_F17_L1.0761.00
68_K82_L1.0571.00
48_K56_F1.0371.00
20_N43_A1.0131.00
72_K75_K1.0061.00
66_N82_L0.9961.00
6_F15_N0.9931.00
22_L41_D0.9931.00
19_L46_L0.9921.00
14_E57_R0.9821.00
41_D64_D0.9781.00
14_E50_G0.9771.00
27_A40_L0.9761.00
39_S66_N0.9761.00
24_N39_S0.9511.00
28_N39_S0.9341.00
63_I89_F0.9301.00
33_K72_K0.9291.00
49_Q57_R0.9281.00
25_L40_L0.9241.00
67_S83_L0.9211.00
61_D88_Q0.9041.00
70_G78_Y0.9021.00
45_G59_T0.9001.00
20_N45_G0.8991.00
35_S70_G0.8971.00
46_L90_A0.8941.00
28_N38_N0.8811.00
38_N65_L0.8801.00
88_Q92_G0.8651.00
51_D55_G0.8581.00
2_S20_N0.8551.00
70_G80_S0.8531.00
2_S18_S0.8341.00
21_G42_L0.8251.00
36_W69_Y0.8241.00
5_S15_N0.8221.00
45_G58_K0.8151.00
29_Y32_G0.8111.00
27_A65_L0.8101.00
15_N50_G0.8091.00
52_Q55_G0.7741.00
30_K37_D0.7611.00
33_K73_A0.7591.00
37_D70_G0.7501.00
22_L43_A0.7401.00
3_Q17_L0.7391.00
21_G25_L0.7381.00
12_G16_S0.7211.00
11_A58_K0.7201.00
35_S68_K0.7151.00
58_K92_G0.7121.00
68_K80_S0.6941.00
82_L86_R0.6801.00
37_D78_Y0.6751.00
28_N35_S0.6731.00
79_Y83_L0.6691.00
48_K52_Q0.6681.00
47_V57_R0.6671.00
63_I85_F0.6631.00
4_S18_S0.6621.00
18_S47_V0.6601.00
26_F37_D0.6541.00
14_E52_Q0.6501.00
27_A38_N0.6371.00
17_L48_K0.6351.00
39_S64_D0.6331.00
72_K76_K0.6301.00
64_D82_L0.6281.00
75_K78_Y0.6111.00
35_S72_K0.5921.00
52_Q56_F0.5811.00
73_A78_Y0.5811.00
45_G92_G0.5791.00
4_S16_S0.5791.00
74_S78_Y0.5741.00
19_L23_L0.5581.00
24_N27_A0.5541.00
77_W80_S0.5541.00
43_A82_L0.5531.00
34_F79_Y0.5511.00
71_Y79_Y0.5491.00
65_L85_F0.5481.00
18_S59_T0.5340.99
13_G18_S0.5340.99
57_R92_G0.5310.99
14_E51_D0.5290.99
66_N80_S0.5290.99
9_W87_T0.5140.99
38_N42_L0.5140.99
42_L90_A0.5130.99
4_S13_G0.5110.99
81_A85_F0.5100.99
10_A14_E0.5060.99
50_G56_F0.5060.99
85_F88_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x9kA 1 0.9785 7.5 0.888 Contact Map
3k63A 1 0.4409 4.8 0.898 Contact Map
4rl8A 3 0.9247 4.5 0.899 Contact Map
2krtA 1 0.4946 3.8 0.903 Contact Map
3nb3A 2 0.8602 2.1 0.915 Contact Map
3qraA 1 0.6237 1.2 0.927 Contact Map
1ormA 1 0.5591 1.2 0.927 Contact Map
4x1cC 5 0.2258 1 0.929 Contact Map
4fqeA 1 0.7204 0.9 0.931 Contact Map
1ajoA 1 0.9785 0.9 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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