GREMLIN Database
DUF3077 - Protein of unknown function (DUF3077)
PFAM: PF11275 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (73)
Sequences: 583 (325)
Seq/√Len: 38.0
META: 0.439

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_S72_D3.7181.00
40_A64_S3.3981.00
68_K72_D2.4671.00
19_R73_D2.4361.00
63_L66_M2.2470.99
44_A60_A2.1840.99
8_G32_H1.9900.99
18_F71_V1.8200.98
32_H36_L1.7980.97
51_D54_D1.7500.97
48_A57_A1.7390.97
17_L24_V1.6500.96
43_L62_Y1.5930.95
31_E63_L1.4910.92
47_A56_L1.4250.91
59_A63_L1.3920.89
15_Q27_E1.3060.86
39_C59_A1.2890.85
30_L71_V1.2860.85
39_C43_L1.2750.85
7_F70_L1.2680.84
60_A63_L1.2330.83
43_L59_A1.2120.82
31_E64_S1.1870.80
30_L74_V1.1710.79
48_A53_T1.1630.79
58_W61_H1.1570.79
32_H52_D1.1420.78
39_C49_M1.0980.75
41_K67_A1.0930.74
23_G26_L1.0930.74
71_V75_V1.0530.72
23_G73_D1.0510.71
35_D70_L1.0460.71
63_L73_D1.0420.71
32_H61_H1.0070.68
41_K65_E1.0060.68
54_D58_W1.0020.68
9_Y39_C0.9990.68
34_S50_E0.9950.67
40_A67_A0.9730.65
24_V29_A0.9720.65
16_P39_C0.9560.64
21_N72_D0.9460.63
41_K64_S0.9450.63
20_V23_G0.9390.63
4_L11_G0.9170.61
32_H39_C0.9030.60
17_L26_L0.8940.59
3_G62_Y0.8920.59
20_V70_L0.8920.59
5_T9_Y0.8870.58
46_D61_H0.8580.56
22_P73_D0.8580.56
17_L53_T0.8430.54
62_Y66_M0.8210.52
5_T16_P0.8100.51
44_A66_M0.8030.51
30_L65_E0.7920.50
4_L67_A0.7910.50
21_N28_D0.7900.50
41_K71_V0.7880.49
40_A55_R0.7840.49
22_P71_V0.7800.49
44_A61_H0.7790.49
30_L48_A0.7730.48
49_M58_W0.7690.48
34_S68_K0.7680.48
29_A33_A0.7600.47
57_A61_H0.7570.47
62_Y68_K0.7510.46
47_A57_A0.7400.45
55_R63_L0.7180.43
6_P11_G0.7160.43
6_P19_R0.7110.43
14_D63_L0.7010.42
52_D56_L0.6960.41
18_F40_A0.6810.40
59_A66_M0.6550.38
65_E72_D0.6470.37
19_R66_M0.6440.37
67_A75_V0.6320.36
7_F31_E0.6320.36
25_P55_R0.6160.35
5_T11_G0.6150.35
34_S54_D0.6140.34
10_C75_V0.6110.34
32_H65_E0.6100.34
13_S20_V0.6080.34
69_A73_D0.6070.34
39_C72_D0.5990.33
13_S69_A0.5920.33
8_G38_G0.5870.32
46_D55_R0.5840.32
4_L9_Y0.5770.32
6_P10_C0.5760.31
21_N65_E0.5720.31
10_C31_E0.5720.31
5_T8_G0.5700.31
18_F33_A0.5660.31
56_L59_A0.5620.30
20_V26_L0.5590.30
3_G73_D0.5470.29
12_N26_L0.5390.29
71_V74_V0.5380.29
10_C70_L0.5150.27
4_L10_C0.5110.27
32_H40_A0.5110.27
51_D67_A0.5070.26
35_D58_W0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ztjA 2 0.8701 7.9 0.905 Contact Map
1vjeA 2 0.961 7.6 0.906 Contact Map
1j98A 2 0.961 6.9 0.908 Contact Map
3ewbX 2 0.987 6 0.91 Contact Map
3rmjA 2 0.987 5.9 0.911 Contact Map
1j6xA 2 0.961 5.8 0.911 Contact Map
1j6wA 2 0.974 5.5 0.912 Contact Map
1ub0A 2 0.7013 4.9 0.914 Contact Map
4xchA 4 0.974 4.8 0.915 Contact Map
4yt2A 2 0.974 4.7 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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