GREMLIN Database
DUF3073 - Protein of unknown function (DUF3073)
PFAM: PF11273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (60)
Sequences: 3783 (2569)
Seq/√Len: 331.6
META: 0.844

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_D29_Q3.1041.00
5_A25_L2.5711.00
55_D58_D2.4661.00
29_Q33_G2.2371.00
5_A9_Q2.1921.00
12_V16_L1.9631.00
5_A19_S1.9181.00
12_V18_Y1.8211.00
27_A30_R1.7121.00
44_D47_D1.7091.00
19_S22_D1.6851.00
23_T31_E1.6511.00
15_E22_D1.6091.00
45_D48_D1.5211.00
10_T15_E1.5171.00
6_K10_T1.5061.00
56_Y59_Y1.4061.00
8_K12_V1.3591.00
39_D42_D1.3221.00
18_Y23_T1.3071.00
9_Q24_D1.2851.00
21_P29_Q1.2821.00
22_D25_L1.2721.00
19_S23_T1.2441.00
12_V23_T1.1871.00
10_T21_P1.1851.00
21_P27_A1.1401.00
9_Q12_V1.1201.00
43_D46_D1.0831.00
44_D48_D1.0521.00
37_S40_D1.0481.00
57_D60_A1.0451.00
9_Q16_L1.0051.00
27_A31_E0.9841.00
10_T19_S0.9771.00
19_S26_D0.9331.00
29_Q34_G0.9051.00
19_S25_L0.8981.00
49_D52_Y0.8561.00
15_E19_S0.8491.00
22_D33_G0.8481.00
39_D43_D0.8391.00
19_S27_A0.8371.00
40_D43_D0.8301.00
55_D59_Y0.8131.00
15_E21_P0.8101.00
21_P25_L0.8001.00
19_S33_G0.7991.00
35_G38_S0.7951.00
38_S41_D0.7621.00
56_Y60_A0.7440.99
1_G4_R0.7260.99
26_D33_G0.7100.99
20_S27_A0.7090.99
23_T29_Q0.7070.99
54_D59_Y0.6910.99
27_A33_G0.6850.99
38_S43_D0.6840.99
23_T32_L0.6790.99
22_D27_A0.6750.99
36_S39_D0.6750.99
53_D60_A0.6660.99
53_D56_Y0.6610.99
48_D51_D0.6250.98
13_A16_L0.6200.98
52_Y55_D0.6140.98
23_T27_A0.6050.98
50_D53_D0.6000.98
5_A27_A0.5990.98
55_D60_A0.5920.97
11_K15_E0.5850.97
41_D46_D0.5800.97
38_S44_D0.5690.97
24_D27_A0.5600.96
41_D45_D0.5570.96
42_D45_D0.5450.96
26_D30_R0.5450.96
50_D54_D0.5420.96
42_D47_D0.5400.95
53_D57_D0.5360.95
24_D30_R0.5230.95
15_E30_R0.5210.94
15_E26_D0.5190.94
53_D59_Y0.5180.94
53_D58_D0.5120.94
37_S42_D0.5110.94
41_D48_D0.5090.94
38_S42_D0.5000.93
11_K16_L0.5000.93
43_D47_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kblA 2 0 9.7 0.897 Contact Map
2ezdA 1 0.127 7.5 0.902 Contact Map
3mwyW 2 0 2.5 0.922 Contact Map
4u7aA 1 0 2.4 0.923 Contact Map
3huuA 2 0.4127 2.3 0.924 Contact Map
1g2rA 1 0.6984 2.2 0.924 Contact Map
2qx5A 1 0.4762 2.2 0.925 Contact Map
2c8mA 1 0.4444 2.2 0.925 Contact Map
3cmuA 1 0.3968 2.1 0.926 Contact Map
4n78D 1 0.4921 1.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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