GREMLIN Database
DUF3072 - Protein of unknown function (DUF3072)
PFAM: PF11272 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (55)
Sequences: 3937 (1231)
Seq/√Len: 166.0
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_R51_E3.4121.00
6_D47_K3.2801.00
15_M20_A2.5411.00
32_E55_K2.3281.00
24_K36_F2.1711.00
24_K28_E1.9361.00
44_E47_K1.9311.00
20_A24_K1.8831.00
32_E48_R1.7761.00
27_A36_F1.6531.00
18_A28_E1.5731.00
30_A56_T1.5721.00
4_D7_D1.5401.00
23_L26_L1.5131.00
20_A38_E1.4761.00
53_Q58_R1.3951.00
21_S25_T1.3741.00
53_Q56_T1.3381.00
2_E9_V1.2571.00
10_T13_E1.1351.00
17_G21_S1.1151.00
29_E56_T1.0921.00
12_D41_T1.0831.00
15_M36_F1.0801.00
24_K38_E1.0751.00
22_Y53_Q1.0130.99
22_Y46_S1.0090.99
25_T29_E1.0050.99
32_E51_E0.9780.99
42_K46_S0.9650.99
22_Y25_T0.9560.99
8_W42_K0.9280.99
51_E55_K0.9150.98
46_S50_D0.9140.98
20_A36_F0.8930.98
3_K9_V0.8830.98
13_E42_K0.8600.98
36_F39_D0.8560.98
41_T44_E0.8520.97
44_E48_R0.8290.97
24_K27_A0.8070.96
9_V28_E0.7750.96
36_F48_R0.7730.96
48_R52_L0.7360.94
16_T19_Q0.7290.94
11_G40_L0.7230.94
2_E6_D0.6960.92
7_D28_E0.6890.92
29_E58_R0.6820.92
18_A21_S0.6760.91
46_S53_Q0.6620.90
10_T56_T0.6580.90
21_S50_D0.6480.89
15_M40_L0.6360.88
13_E16_T0.6320.88
23_L40_L0.6090.86
22_Y42_K0.6080.86
18_A50_D0.6070.86
27_A32_E0.6050.86
8_W13_E0.6040.86
43_A50_D0.5980.85
13_E46_S0.5930.85
22_Y31_G0.5920.85
28_E33_E0.5880.84
14_P26_L0.5850.84
27_A48_R0.5840.84
18_A22_Y0.5820.84
36_F40_L0.5770.83
23_L45_A0.5720.83
5_P18_A0.5650.82
15_M37_D0.5370.79
3_K17_G0.5340.78
16_T49_I0.5340.78
13_E53_Q0.5310.78
30_A53_Q0.5290.77
2_E7_D0.5170.76
23_L36_F0.5160.76
2_E18_A0.5140.75
54_E57_G0.5080.75
30_A55_K0.5040.74
20_A48_R0.5030.74
20_A54_E0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qt7A 3 0.8621 16.6 0.856 Contact Map
3mfqA 1 0.9828 12.1 0.865 Contact Map
4pzjA 2 0.7586 12 0.865 Contact Map
3j3iA 6 0.931 11.6 0.866 Contact Map
4htiA 1 0.8621 11.5 0.866 Contact Map
1al3A 1 0 11.1 0.867 Contact Map
1ykdA 2 0.7586 11 0.867 Contact Map
1ixcA 4 0.7586 10.5 0.868 Contact Map
2h98A 2 0 10.4 0.869 Contact Map
4r60A 2 0.7586 10 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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