GREMLIN Database
DUF3068 - Protein of unknown function (DUF3068)
PFAM: PF11271 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 300 (285)
Sequences: 1626 (1201)
Seq/√Len: 71.2
META: 0.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_T181_F8.8461.00
169_G180_R3.4471.00
285_I289_V3.3871.00
151_T164_P3.1931.00
267_D271_D3.1461.00
171_E178_V2.9441.00
176_L266_V2.9211.00
214_R230_E2.8931.00
170_E177_T2.8891.00
17_L21_F2.7821.00
16_A288_L2.7301.00
219_E273_R2.7171.00
180_R215_T2.6991.00
282_T286_V2.6521.00
9_G291_G2.6171.00
149_K179_Y2.5901.00
49_D52_T2.5711.00
263_A267_D2.4471.00
168_V182_T2.3511.00
178_V226_V2.3291.00
189_K207_T2.3111.00
259_D263_A2.2631.00
171_E217_W2.2151.00
42_G45_A2.1971.00
42_G253_A2.1821.00
231_H254_T2.1681.00
173_V178_V2.1421.00
30_L110_F2.1101.00
222_T272_N2.1041.00
167_Y170_E2.0741.00
227_K256_T2.0551.00
151_T166_R2.0341.00
278_L283_L2.0221.00
66_A255_L1.9441.00
231_H252_D1.9021.00
184_T213_T1.8101.00
23_V27_L1.8021.00
182_T215_T1.7991.00
153_P164_P1.7631.00
106_D136_R1.7261.00
171_E180_R1.7251.00
257_F261_T1.7141.00
80_V118_V1.7061.00
176_L220_P1.6831.00
168_V180_R1.6821.00
35_D69_T1.6531.00
45_A253_A1.6480.99
259_D262_V1.6440.99
72_G81_A1.6330.99
147_T220_P1.6320.99
154_Y165_A1.6290.99
165_A183_Q1.6270.99
143_F181_F1.6180.99
176_L219_E1.6050.99
294_L297_A1.5940.99
174_D263_A1.5940.99
172_T177_T1.5770.99
139_L143_F1.5750.99
28_A146_G1.5690.99
24_V28_A1.5570.99
278_L282_T1.5520.99
159_L163_V1.5440.99
116_E153_P1.5380.99
147_T219_E1.5330.99
173_V227_K1.5260.99
167_Y179_Y1.5110.99
182_T213_T1.5030.99
281_T285_I1.4960.99
148_E152_Y1.4770.99
19_L287_L1.4700.99
20_R288_L1.4430.99
189_K209_Y1.4300.99
123_C126_G1.4240.98
68_R228_G1.4230.98
149_K167_Y1.4150.98
282_T285_I1.4150.98
143_F147_T1.4080.98
221_V273_R1.4070.98
227_K262_V1.3980.98
24_V280_G1.3960.98
271_D275_K1.3870.98
217_W227_K1.3750.98
149_K170_E1.3670.98
180_R217_W1.3550.98
178_V217_W1.3500.98
143_F216_L1.3480.98
28_A276_L1.3480.98
154_Y216_L1.3360.98
264_A268_L1.3220.98
200_G203_V1.3130.97
142_K145_F1.3080.97
64_L253_A1.2740.97
117_A136_R1.2680.97
143_F165_A1.2500.97
226_V265_Q1.2470.96
32_L112_R1.2230.96
65_T92_D1.2190.96
52_T55_A1.2170.96
38_T70_V1.2060.96
156_D210_Y1.2060.96
124_C127_A1.2050.96
122_N125_G1.1880.95
152_Y179_Y1.1720.95
73_D107_R1.1710.95
251_L255_L1.1640.95
265_Q269_A1.1610.95
116_E139_L1.1570.95
289_V296_V1.1530.95
183_Q214_R1.1520.95
30_L142_K1.1480.94
83_W110_F1.1360.94
229_E254_T1.1360.94
71_K84_D1.1280.94
277_R282_T1.1250.94
81_A112_R1.1110.93
272_N279_L1.1100.93
12_L287_L1.1060.93
17_L288_L1.1040.93
163_V183_Q1.0980.93
273_R277_R1.0910.93
123_C129_V1.0840.93
2_G298_G1.0750.92
272_N275_K1.0700.92
52_T56_G1.0690.92
123_C128_P1.0670.92
233_R252_D1.0670.92
115_G139_L1.0480.91
48_L52_T1.0430.91
209_Y235_T1.0380.91
291_G298_G1.0310.91
84_D107_R1.0290.90
18_L22_Y1.0290.90
30_L83_W1.0240.90
174_D266_V1.0140.90
261_T265_Q1.0060.89
21_F25_P1.0050.89
41_E258_T1.0050.89
141_Y261_T1.0040.89
170_E179_Y1.0010.89
185_V188_T0.9910.89
279_L283_L0.9880.89
277_R281_T0.9840.88
123_C127_A0.9820.88
176_L226_V0.9790.88
11_F18_L0.9730.88
176_L270_K0.9720.88
7_G11_F0.9720.88
174_D262_V0.9690.88
12_L290_L0.9600.87
32_L76_S0.9520.87
80_V109_A0.9500.87
108_Y141_Y0.9470.86
213_T231_H0.9470.86
159_L188_T0.9460.86
143_F218_V0.9420.86
91_D94_G0.9370.86
267_D292_L0.9290.85
64_L101_L0.9260.85
13_L290_L0.9240.85
117_A140_V0.9230.85
125_G128_P0.9220.85
159_L190_V0.9050.84
8_L32_L0.9050.84
155_F276_L0.9050.84
190_V234_Q0.9040.84
131_A135_P0.8960.83
293_V297_A0.8940.83
130_G133_A0.8880.83
27_L30_L0.8870.83
226_V269_A0.8860.82
229_E256_T0.8850.82
149_K152_Y0.8820.82
212_N230_E0.8820.82
111_D114_T0.8800.82
262_V266_V0.8750.82
211_S214_R0.8740.82
39_V258_T0.8730.82
108_Y140_V0.8720.81
156_D219_E0.8700.81
227_K257_F0.8700.81
217_W229_E0.8590.80
168_V213_T0.8530.80
137_E162_A0.8480.80
17_L20_R0.8400.79
124_C130_G0.8390.79
278_L284_P0.8390.79
75_A82_V0.8360.79
134_V155_F0.8330.78
224_A272_N0.8300.78
124_C128_P0.8300.78
105_T211_S0.8270.78
22_Y26_R0.8230.78
278_L286_V0.8230.78
289_V293_V0.8220.77
48_L53_L0.8220.77
126_G297_A0.8220.77
209_Y237_R0.8210.77
187_P211_S0.8200.77
269_A273_R0.8180.77
127_A130_G0.8170.77
270_K274_D0.8150.77
195_T203_V0.8090.76
241_G244_G0.8090.76
212_N255_L0.8080.76
260_A264_A0.8060.76
186_P211_S0.8040.76
6_L298_G0.8040.76
42_G64_L0.7980.75
81_A110_F0.7980.75
274_D278_L0.7970.75
224_A269_A0.7970.75
198_V203_V0.7940.75
159_L250_L0.7920.75
249_T252_D0.7910.75
274_D282_T0.7840.74
122_N126_G0.7820.74
6_L295_L0.7810.74
218_V225_I0.7780.74
238_D241_G0.7780.74
86_G103_A0.7740.73
40_L228_G0.7700.73
233_R249_T0.7680.73
258_T261_T0.7620.72
4_V296_V0.7600.72
257_F265_Q0.7560.71
19_L283_L0.7500.71
83_W87_T0.7480.71
283_L287_L0.7480.71
26_R29_K0.7470.70
290_L297_A0.7440.70
111_D118_V0.7440.70
153_P165_A0.7360.69
124_C131_A0.7360.69
40_L68_R0.7300.69
150_K179_Y0.7270.68
13_L291_G0.7240.68
222_T226_V0.7230.68
97_D100_L0.7230.68
162_A183_Q0.7190.68
292_L296_V0.7180.67
264_A267_D0.7170.67
167_Y266_V0.7170.67
142_K222_T0.7150.67
89_V155_F0.7080.66
266_V270_K0.7070.66
203_V206_L0.7060.66
126_G129_V0.7050.66
68_R87_T0.7020.66
165_A216_L0.7020.66
30_L145_F0.7010.66
75_A84_D0.6990.65
262_V267_D0.6980.65
16_A21_F0.6890.64
53_L56_G0.6860.64
37_T222_T0.6860.64
166_R174_D0.6850.64
47_Y91_D0.6810.63
29_K42_G0.6770.63
67_T236_L0.6740.63
287_L294_L0.6720.62
108_Y115_G0.6670.62
198_V202_L0.6650.61
6_L299_L0.6630.61
216_L225_I0.6630.61
82_V109_A0.6620.61
63_P92_D0.6600.61
107_R226_V0.6590.61
47_Y62_V0.6580.61
216_L228_G0.6520.60
130_G134_V0.6500.60
164_P183_Q0.6480.59
109_A118_V0.6480.59
73_D84_D0.6470.59
217_W220_P0.6460.59
29_K113_R0.6460.59
154_Y158_T0.6450.59
85_V141_Y0.6440.59
81_A225_I0.6410.59
37_T67_T0.6400.59
197_T200_G0.6380.58
173_V266_V0.6370.58
172_T267_D0.6330.58
49_D65_T0.6300.57
195_T200_G0.6300.57
146_G221_V0.6270.57
230_E290_L0.6250.57
127_A132_D0.6240.57
44_T61_G0.6230.57
19_L23_V0.6230.57
207_T240_G0.6220.56
155_F257_F0.6210.56
117_A139_L0.6200.56
156_D214_R0.6200.56
82_V118_V0.6170.56
7_G14_V0.6150.56
181_F298_G0.6150.56
125_G129_V0.6130.55
179_Y220_P0.6130.55
44_T63_P0.6120.55
125_G130_G0.6080.55
9_G298_G0.6080.55
93_D100_L0.6070.55
124_C132_D0.6070.55
36_S104_T0.6060.54
128_P133_A0.6060.54
161_K188_T0.6050.54
104_T157_P0.6030.54
267_D270_K0.6030.54
10_A14_V0.6020.54
296_V299_L0.6010.54
156_D185_V0.6000.54
9_G13_L0.5990.54
20_R107_R0.5980.53
27_L145_F0.5970.53
11_F40_L0.5950.53
35_D71_K0.5940.53
23_V30_L0.5920.53
2_G6_L0.5920.53
128_P131_A0.5920.53
36_S102_S0.5890.52
123_C131_A0.5890.52
150_K166_R0.5890.52
6_L34_L0.5880.52
275_K279_L0.5870.52
31_P152_Y0.5850.52
265_Q268_L0.5840.52
136_R140_V0.5810.51
237_R243_G0.5800.51
21_F276_L0.5800.51
39_V46_T0.5770.51
83_W141_Y0.5770.51
84_D167_Y0.5760.51
10_A54_A0.5760.51
140_V155_F0.5750.51
240_G244_G0.5750.51
16_A82_V0.5750.51
197_T205_T0.5730.50
139_L153_P0.5710.50
225_I257_F0.5710.50
41_E63_P0.5710.50
155_F268_L0.5700.50
250_L262_V0.5670.50
116_E138_G0.5670.50
131_A134_V0.5650.49
15_L74_A0.5640.49
265_Q273_R0.5630.49
9_G295_L0.5630.49
208_R234_Q0.5600.49
67_T75_A0.5600.49
8_L61_G0.5580.49
25_P284_P0.5580.49
16_A284_P0.5560.48
198_V235_T0.5550.48
218_V227_K0.5550.48
52_T239_P0.5540.48
244_G276_L0.5520.48
29_K78_S0.5500.48
81_A85_V0.5490.47
145_F256_T0.5480.47
5_L10_A0.5480.47
62_V115_G0.5480.47
204_V208_R0.5470.47
80_V213_T0.5470.47
285_I297_A0.5460.47
222_T269_A0.5460.47
4_V260_A0.5460.47
286_V290_L0.5460.47
112_R156_D0.5430.47
8_L15_L0.5420.47
67_T88_T0.5390.46
201_S296_V0.5390.46
30_L33_D0.5360.46
61_G295_L0.5360.46
181_F261_T0.5350.46
41_E76_S0.5340.46
197_T202_L0.5340.46
5_L290_L0.5340.46
5_L169_G0.5340.46
293_V296_V0.5320.45
195_T201_S0.5310.45
35_D86_G0.5310.45
155_F209_Y0.5300.45
80_V91_D0.5300.45
47_Y255_L0.5280.45
156_D230_E0.5280.45
187_P190_V0.5280.45
86_G91_D0.5280.45
143_F154_Y0.5270.45
34_L72_G0.5270.45
47_Y81_A0.5250.45
221_V277_R0.5240.44
60_T219_E0.5240.44
189_K195_T0.5240.44
222_T283_L0.5230.44
274_D281_T0.5230.44
237_R244_G0.5200.44
168_V215_T0.5180.44
4_V126_G0.5180.44
169_G219_E0.5170.44
20_R24_V0.5150.43
52_T84_D0.5140.43
199_P202_L0.5140.43
68_R212_N0.5130.43
276_L284_P0.5130.43
47_Y55_A0.5130.43
189_K259_D0.5120.43
40_L140_V0.5110.43
64_L89_V0.5100.43
47_Y101_L0.5100.43
84_D149_K0.5090.43
61_G161_K0.5090.43
85_V106_D0.5080.43
50_P56_G0.5080.43
238_D243_G0.5080.43
198_V236_L0.5070.42
66_A206_L0.5060.42
198_V201_S0.5050.42
196_L203_V0.5040.42
22_Y27_L0.5030.42
49_D91_D0.5030.42
41_E77_D0.5030.42
67_T90_R0.5020.42
229_E262_V0.5020.42
8_L95_G0.5010.42
90_R130_G0.5010.42
49_D218_V0.5010.42
24_V276_L0.5000.42
123_C130_G0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4fA 1 0.8233 63.7 0.94 Contact Map
2byoA 1 0.5833 17.4 0.956 Contact Map
3mh9C 1 0.6233 13 0.959 Contact Map
2mc7A 1 0.0867 8.3 0.962 Contact Map
1s7qA 1 0 7.9 0.963 Contact Map
2kluA 1 0.09 6.2 0.964 Contact Map
4qa8A 1 0.5767 5.3 0.966 Contact Map
4um9B 2 0 4.3 0.967 Contact Map
2qjyB 1 0.5767 4.2 0.967 Contact Map
2j5lA 1 0 3.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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