GREMLIN Database
DUF3071 - Protein of unknown function (DUF3071)
PFAM: PF11268 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 166 (166)
Sequences: 2195 (1333)
Seq/√Len: 103.5
META: 0.755

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_E80_V3.5371.00
15_H27_R3.2881.00
18_L28_L3.2551.00
69_A80_V3.1311.00
69_A87_A2.9821.00
45_Q48_I2.9411.00
98_A138_D2.8051.00
102_R118_G2.7101.00
62_R67_E2.6181.00
84_E87_A2.5531.00
70_E74_A2.5271.00
3_E27_R2.4771.00
67_E71_E2.4601.00
76_A83_V2.3991.00
78_V83_V2.3001.00
152_T161_T2.2811.00
135_V151_L2.2611.00
140_W150_T2.0971.00
67_E75_A2.0801.00
102_R122_A2.0621.00
62_R75_A2.0321.00
20_D24_E2.0271.00
96_H100_Q1.9041.00
96_H99_E1.8731.00
85_R88_G1.8171.00
94_R138_D1.8021.00
63_I72_V1.7061.00
107_R110_D1.6831.00
10_S15_H1.6581.00
6_L18_L1.6461.00
2_R26_F1.5861.00
46_L50_V1.5761.00
10_S14_E1.5691.00
123_E127_A1.5341.00
2_R24_E1.5021.00
4_L26_F1.4681.00
131_D134_D1.4581.00
157_G160_R1.4481.00
150_T163_R1.4231.00
155_A158_R1.3861.00
63_I98_A1.3721.00
154_T157_G1.3671.00
59_I78_V1.3330.99
146_R164_W1.3160.99
91_L95_A1.3130.99
81_E84_E1.3070.99
54_L76_A1.3050.99
116_T119_E1.2890.99
70_E84_E1.2680.99
125_L130_V1.2550.99
6_L16_L1.2490.99
47_E50_V1.2460.99
72_V76_A1.2430.99
69_A84_E1.2400.99
148_T164_W1.2320.99
33_R37_A1.2270.99
63_I141_R1.2160.99
46_L49_E1.2080.99
140_W148_T1.2060.99
39_R42_R1.1950.99
155_A160_R1.1720.98
91_L94_R1.1640.98
45_Q50_V1.1230.98
52_S78_V1.1150.98
8_G25_R1.1140.98
10_S27_R1.1090.98
63_I90_V1.0990.98
101_A117_L1.0970.98
55_R58_E1.0900.98
152_T159_E1.0790.97
15_H18_L1.0730.97
37_A40_G1.0680.97
150_T161_T1.0580.97
73_A80_V1.0570.97
6_L28_L1.0470.97
20_D26_F1.0470.97
140_W143_E1.0460.97
78_V82_R1.0200.96
80_V84_E1.0180.96
67_E72_V1.0090.96
36_A61_A0.9970.96
48_I51_E0.9910.96
35_R38_V0.9890.96
37_A41_D0.9780.95
92_A95_A0.9770.95
61_A72_V0.9770.95
72_V83_V0.9690.95
8_G16_L0.9610.95
96_H104_A0.9530.95
73_A76_A0.9410.94
72_V75_A0.9390.94
116_T120_A0.9250.94
118_G122_A0.9200.94
154_T160_R0.9140.93
32_D35_R0.9020.93
86_F90_V0.9020.93
61_A65_A0.8960.93
17_V24_E0.8930.93
94_R98_A0.8910.92
134_D154_T0.8910.92
30_I38_V0.8810.92
140_W144_D0.8800.92
98_A117_L0.8720.92
9_L17_V0.8700.92
7_V19_A0.8660.91
41_D46_L0.8660.91
36_A39_R0.8630.91
38_V49_E0.8620.91
20_D23_G0.8620.91
28_L109_A0.8580.91
124_R153_F0.8510.91
54_L78_V0.8490.90
58_E148_T0.8460.90
39_R55_R0.8340.90
15_H29_P0.8330.90
111_G115_L0.8290.89
153_F158_R0.8280.89
8_G101_A0.8170.89
41_D57_R0.8120.88
2_R9_L0.8090.88
46_L51_E0.7980.88
38_V42_R0.7920.87
95_A99_E0.7880.87
25_R29_P0.7880.87
15_H85_R0.7870.87
154_T159_E0.7860.87
142_R165_S0.7850.87
3_E15_H0.7840.87
122_A135_V0.7840.87
6_L95_A0.7830.87
58_E90_V0.7730.86
113_S123_E0.7720.86
88_G92_A0.7720.86
131_D135_V0.7700.86
109_A113_S0.7680.86
8_G19_A0.7660.85
112_P115_L0.7610.85
35_R39_R0.7580.85
68_S71_E0.7540.84
59_I101_A0.7450.84
9_L12_D0.7450.84
132_P135_V0.7290.82
28_L34_L0.7230.82
41_D49_E0.7020.80
19_A25_R0.7010.80
87_A153_F0.6940.79
97_V139_A0.6930.79
112_P128_R0.6900.79
3_E21_D0.6880.79
36_A40_G0.6880.79
72_V77_G0.6830.78
111_G120_A0.6820.78
154_T161_T0.6740.77
128_R166_F0.6730.77
41_D44_R0.6720.77
19_A110_D0.6640.76
32_D81_E0.6630.76
22_D25_R0.6630.76
117_L128_R0.6620.76
56_P92_A0.6590.76
143_E154_T0.6580.76
69_A88_G0.6530.75
87_A91_L0.6510.75
3_E7_V0.6480.74
10_S153_F0.6470.74
78_V120_A0.6460.74
157_G166_F0.6450.74
154_T165_S0.6440.74
72_V166_F0.6420.74
32_D48_I0.6410.74
153_F156_G0.6340.73
4_L8_G0.6330.73
71_E75_A0.6330.73
17_V28_L0.6330.73
148_T154_T0.6310.72
71_E74_A0.6300.72
76_A86_F0.6280.72
60_Q64_R0.6150.71
45_Q51_E0.6150.71
17_V20_D0.6140.70
102_R129_G0.6120.70
44_R47_E0.6110.70
5_R129_G0.6090.70
73_A83_V0.6040.69
38_V146_R0.6030.69
32_D36_A0.6030.69
16_L51_E0.6030.69
35_R100_Q0.6020.69
127_A131_D0.6000.69
156_G160_R0.5950.68
2_R7_V0.5910.68
161_T165_S0.5880.67
105_R128_R0.5880.67
7_V20_D0.5870.67
20_D28_L0.5860.67
52_S76_A0.5790.66
62_R140_W0.5790.66
33_R82_R0.5780.66
103_A119_E0.5780.66
158_R165_S0.5780.66
9_L14_E0.5750.65
110_D113_S0.5750.65
162_A166_F0.5740.65
88_G94_R0.5740.65
56_P101_A0.5710.65
107_R124_R0.5690.65
92_A98_A0.5630.64
133_D159_E0.5610.64
2_R18_L0.5600.63
38_V46_L0.5590.63
143_E146_R0.5590.63
138_D156_G0.5580.63
16_L97_V0.5570.63
36_A41_D0.5560.63
130_V153_F0.5550.63
134_D143_E0.5540.63
110_D115_L0.5530.62
149_V152_T0.5500.62
53_A82_R0.5500.62
101_A138_D0.5460.61
3_E29_P0.5450.61
103_A130_V0.5450.61
146_R165_S0.5440.61
124_R160_R0.5440.61
110_D156_G0.5440.61
83_V127_A0.5430.61
11_E17_V0.5390.60
58_E112_P0.5390.60
16_L25_R0.5380.60
1_M24_E0.5370.60
154_T158_R0.5370.60
125_L132_P0.5350.60
96_H106_V0.5330.60
11_E25_R0.5330.60
78_V90_V0.5300.59
125_L141_R0.5270.59
11_E29_P0.5230.58
13_G17_V0.5210.58
2_R28_L0.5200.58
58_E109_A0.5180.57
132_P136_E0.5120.57
90_V93_E0.5080.56
118_G132_P0.5080.56
13_G86_F0.5080.56
142_R145_G0.5080.56
113_S120_A0.5070.56
79_P82_R0.5060.56
123_E126_A0.5030.55
33_R43_P0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sztA 2 0.6807 51.5 0.928 Contact Map
3qp6A 2 0.7048 50.7 0.928 Contact Map
1gdtA 2 0.5301 46.1 0.93 Contact Map
1tc3C 1 0.2892 45 0.931 Contact Map
1jhgA 2 0.5241 44.1 0.931 Contact Map
2q0oA 2 0.6627 41.9 0.932 Contact Map
1l3lA 2 0.6627 38.4 0.933 Contact Map
3pxpA 2 0.6807 37.8 0.934 Contact Map
2mqkA 1 0.3675 36.4 0.934 Contact Map
1p4wA 1 0.512 36.4 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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