GREMLIN Database
DUF3055 - Protein of unknown function (DUF3055)
PFAM: PF11256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 549 (317)
Seq/√Len: 35.6
META: 0.455

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_I36_K4.6951.00
27_V39_L3.4341.00
39_L46_S3.4261.00
39_L44_G2.7451.00
28_Y36_K2.4771.00
2_Y14_G2.2270.99
60_L75_R2.0300.98
32_F43_T2.0050.98
6_E30_N1.9370.98
3_D11_R1.9360.98
72_E76_E1.7740.96
67_S70_E1.7350.96
61_E68_E1.6670.95
34_G53_D1.4510.90
40_D43_T1.4340.89
11_R15_F1.4190.89
18_E38_V1.3440.86
20_Q70_E1.3440.86
60_L64_F1.3280.85
70_E77_F1.3050.84
61_E75_R1.2550.82
47_A59_Y1.2180.80
10_T27_V1.2160.80
40_D65_K1.1690.77
4_E45_R1.1670.77
20_Q66_L1.1360.75
38_V49_I1.1160.73
19_S67_S1.1150.73
16_V32_F1.1150.73
32_F41_M1.0900.72
27_V79_Y1.0880.72
3_D13_V1.0880.72
35_K53_D1.0810.71
41_M44_G1.0760.71
22_F64_F1.0750.71
72_E75_R1.0540.69
27_V37_L1.0390.68
1_L14_G1.0350.68
62_H68_E1.0220.67
49_I75_R1.0010.65
51_P65_K0.9970.65
51_P62_H0.9640.62
28_Y40_D0.9510.61
4_E14_G0.9380.60
11_R50_G0.9180.58
20_Q40_D0.9170.58
46_S64_F0.9080.57
15_F77_F0.8920.56
19_S76_E0.8790.55
16_V73_E0.8790.55
45_R65_K0.8790.55
8_T27_V0.8710.54
43_T70_E0.8700.54
55_E79_Y0.8690.54
29_T34_G0.8620.53
58_G61_E0.8600.53
37_L48_I0.8570.53
11_R25_A0.8500.52
60_L74_L0.8400.52
14_G20_Q0.8380.51
50_G56_E0.8280.51
1_L4_E0.7800.46
11_R71_A0.7800.46
4_E12_F0.7420.43
42_Q53_D0.7230.42
23_D42_Q0.7150.41
68_E72_E0.7130.41
31_R54_L0.7130.41
52_D56_E0.7110.41
66_L74_L0.7110.41
40_D61_E0.7090.40
15_F25_A0.7080.40
29_T33_Y0.7060.40
19_S32_F0.7050.40
9_K45_R0.7030.40
20_Q75_R0.7020.40
42_Q59_Y0.7000.40
28_Y43_T0.6990.40
19_S73_E0.6810.38
19_S22_F0.6680.37
50_G54_L0.6650.37
66_L77_F0.6640.37
5_T25_A0.6570.36
30_N41_M0.6480.35
11_R77_F0.6270.34
33_Y74_L0.6260.34
43_T76_E0.6240.34
49_I52_D0.6210.33
22_F74_L0.6190.33
1_L18_E0.6180.33
12_F39_L0.6150.33
47_A63_V0.6110.33
19_S69_E0.6100.32
47_A78_L0.6050.32
63_V71_A0.6040.32
17_G24_L0.6020.32
21_R38_V0.6000.32
10_T74_L0.5930.31
6_E26_I0.5810.30
60_L67_S0.5790.30
7_E41_M0.5770.30
17_G62_H0.5650.29
31_R40_D0.5560.29
63_V67_S0.5480.28
37_L41_M0.5460.28
48_I59_Y0.5430.28
14_G37_L0.5380.27
15_F73_E0.5340.27
9_K27_V0.5330.27
32_F44_G0.5200.26
17_G50_G0.5180.26
4_E46_S0.5160.26
12_F67_S0.5100.25
49_I54_L0.5090.25
8_T74_L0.5080.25
3_D15_F0.5030.25
76_E79_Y0.5020.25
14_G17_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bijA 5 0.4875 13.6 0.916 Contact Map
1dgwY 1 0.7375 13.3 0.916 Contact Map
4nhxA 1 0.375 12.5 0.917 Contact Map
3kt7A 2 0.4125 9 0.922 Contact Map
1f0kA 2 0.9875 8.6 0.923 Contact Map
4lejA 3 0.7625 8.4 0.923 Contact Map
3fz3A 5 0.8875 7.9 0.924 Contact Map
2ct9A 2 0.4375 7.9 0.924 Contact Map
2ozlA 2 0.9875 7.5 0.925 Contact Map
3e18A 2 0.8625 7.3 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.