GREMLIN Database
DUF3054 - Protein of unknown function (DUF3054)
PFAM: PF11255 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (105)
Sequences: 3838 (2749)
Seq/√Len: 268.3
META: 0.823

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_F103_F3.0911.00
94_V98_V2.8611.00
70_W101_A2.8331.00
74_V97_L2.5621.00
7_A103_F2.5491.00
90_P94_V2.3541.00
78_M93_V2.2291.00
82_A85_G2.1911.00
38_G72_V2.1871.00
3_G107_W2.1321.00
33_W84_F2.0491.00
38_G76_V2.0091.00
5_V36_L1.9791.00
8_V100_L1.9591.00
72_V75_P1.9391.00
32_A36_L1.9241.00
8_V39_L1.9161.00
41_V76_V1.8471.00
16_R21_E1.7721.00
27_G31_T1.6881.00
99_F102_L1.6481.00
16_R31_T1.5111.00
42_G46_V1.4921.00
88_T93_V1.4611.00
91_S95_V1.4611.00
98_V102_L1.4411.00
59_P62_L1.4151.00
82_A86_Q1.3641.00
101_A105_L1.3591.00
16_R27_G1.3541.00
86_Q89_A1.2821.00
9_L32_A1.2521.00
18_S21_E1.2411.00
33_W37_A1.2251.00
53_A68_V1.2011.00
82_A88_T1.1931.00
78_M96_A1.1831.00
62_L65_T1.1491.00
54_R57_R1.1151.00
64_R68_V1.0891.00
13_A28_V1.0721.00
61_A64_R1.0401.00
23_L28_V1.0371.00
97_L101_A1.0131.00
89_A93_V1.0091.00
42_G72_V1.0081.00
39_L43_W0.9781.00
59_P64_R0.9691.00
42_G73_T0.9651.00
11_F96_A0.9541.00
91_S94_V0.9451.00
74_V78_M0.9431.00
20_G24_S0.9421.00
69_V72_V0.9411.00
77_G96_A0.9401.00
60_P64_R0.9361.00
66_G69_V0.9281.00
53_A56_W0.9241.00
12_V32_A0.9221.00
95_V99_F0.9221.00
70_W100_L0.9171.00
70_W104_L0.9041.00
65_T69_V0.9021.00
62_L105_L0.9021.00
80_L84_F0.9011.00
13_A17_A0.8921.00
69_V73_T0.8891.00
10_V14_I0.8771.00
17_A28_V0.8681.00
20_G23_L0.8471.00
39_L73_T0.8461.00
97_L100_L0.8431.00
26_A29_L0.8431.00
74_V96_A0.8401.00
67_V71_L0.8350.99
63_W67_V0.8330.99
100_L104_L0.8320.99
90_P93_V0.8280.99
31_T86_Q0.8240.99
15_G81_R0.8200.99
55_A65_T0.8190.99
80_L83_L0.8160.99
11_F103_F0.8140.99
85_G88_T0.8120.99
37_A84_F0.8100.99
17_A21_E0.7950.99
37_A80_L0.7860.99
11_F16_R0.7780.99
22_G28_V0.7770.99
84_F88_T0.7750.99
7_A104_L0.7680.99
25_L28_V0.7550.99
7_A10_V0.7540.99
2_A6_L0.7520.99
19_H92_F0.7410.99
14_I18_S0.7400.99
29_L33_W0.7390.99
7_A107_W0.7360.99
74_V100_L0.7300.99
65_T68_V0.7260.99
82_A87_G0.7230.99
67_V70_W0.7180.98
5_V44_L0.7170.98
37_A40_A0.7090.98
35_F77_G0.7020.98
15_G19_H0.6900.98
46_V49_L0.6880.98
17_A24_S0.6880.98
12_V74_V0.6820.98
62_L66_G0.6790.98
63_W105_L0.6750.98
12_V28_V0.6740.98
79_L82_A0.6660.97
75_P79_L0.6610.97
46_V72_V0.6590.97
27_G30_R0.6590.97
11_F19_H0.6580.97
64_R67_V0.6580.97
100_L103_F0.6560.97
78_M88_T0.6480.97
53_A57_R0.6480.97
8_V36_L0.6440.97
85_G89_A0.6420.97
3_G60_P0.6390.97
43_W55_A0.6380.97
71_L97_L0.6370.97
45_L49_L0.6190.96
6_L10_V0.6180.96
23_L26_A0.6150.96
91_S99_F0.6110.96
30_R33_W0.6090.96
33_W42_G0.6060.96
16_R28_V0.6050.96
71_L75_P0.6030.95
9_L28_V0.5950.95
72_V76_V0.5890.95
14_I99_F0.5860.95
68_V72_V0.5810.94
91_S97_L0.5750.94
68_V71_L0.5620.93
12_V17_A0.5620.93
104_L107_W0.5620.93
17_A20_G0.5610.93
11_F14_I0.5600.93
96_A99_F0.5550.93
57_R60_P0.5430.92
12_V77_G0.5410.92
46_V54_R0.5400.92
44_L48_P0.5330.92
66_G105_L0.5310.91
33_W106_G0.5270.91
92_F95_V0.5270.91
64_R105_L0.5200.91
36_L44_L0.5160.90
5_V39_L0.5100.90
56_W65_T0.5070.89
31_T34_P0.5040.89
10_V13_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.5225 1.2 0.932 Contact Map
1fl2A 2 0.3333 1 0.936 Contact Map
1hr0W 1 0.2162 1 0.936 Contact Map
1hyuA 2 0.3333 1 0.936 Contact Map
2lotA 1 0.1982 0.9 0.937 Contact Map
4uc1A 3 0.5225 0.9 0.937 Contact Map
4ql5A 4 0.2252 0.9 0.938 Contact Map
4p02A 1 0.6757 0.9 0.938 Contact Map
2ksfA 1 0.4865 0.8 0.939 Contact Map
1xioA 2 0.2162 0.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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