GREMLIN Database
DUF3047 - Protein of unknown function (DUF3047)
PFAM: PF11249 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 183 (180)
Sequences: 7555 (5335)
Seq/√Len: 397.7
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_R140_E4.1911.00
54_S141_R3.0951.00
149_R155_E2.9371.00
143_N146_E2.7901.00
115_P123_R2.7011.00
29_R176_E2.4791.00
133_K138_V2.3971.00
52_I141_R2.3831.00
33_D174_S2.2911.00
128_R133_K2.2851.00
133_K136_Q2.2701.00
78_A177_A2.2471.00
102_Y147_D2.2211.00
34_G172_G2.1131.00
53_L82_V2.0421.00
128_R138_V2.0411.00
32_S168_S2.0361.00
56_R139_T2.0281.00
113_V151_A1.9761.00
166_T179_Y1.9711.00
56_R180_G1.8661.00
25_R56_R1.8581.00
82_V144_V1.7961.00
44_D158_R1.7951.00
82_V159_I1.7881.00
146_E150_R1.7531.00
31_E176_E1.7451.00
69_R108_L1.7051.00
21_E26_R1.6911.00
60_D178_Y1.6831.00
78_A179_Y1.6701.00
5_P14_K1.6671.00
70_T73_G1.6441.00
145_A149_R1.6431.00
63_P77_A1.6211.00
19_L26_R1.6181.00
18_S29_R1.5961.00
46_D49_E1.5931.00
125_I151_A1.5871.00
100_L151_A1.5751.00
62_L134_L1.5531.00
22_D58_K1.5491.00
68_E114_I1.5251.00
127_V142_R1.5241.00
54_S139_T1.5091.00
31_E174_S1.4931.00
113_V150_R1.4501.00
63_P168_S1.3931.00
56_R181_D1.3701.00
51_P143_N1.3571.00
85_D160_V1.3521.00
48_K145_A1.3381.00
28_L164_I1.3351.00
127_V140_E1.3151.00
142_R147_D1.3051.00
25_R180_G1.3051.00
27_V178_Y1.2981.00
29_R178_Y1.2941.00
20_V29_R1.2741.00
17_Y30_A1.2691.00
18_S31_E1.2631.00
166_T175_A1.2431.00
7_T14_K1.2381.00
30_A166_T1.2261.00
21_E24_G1.2241.00
84_F148_Y1.2191.00
109_P112_T1.1961.00
167_D170_N1.1911.00
16_R31_E1.1841.00
22_D27_V1.1721.00
113_V125_I1.1661.00
4_E42_E1.1561.00
67_D70_T1.1501.00
92_P95_E1.1431.00
60_D176_E1.1331.00
166_T177_A1.1291.00
59_V62_L1.0971.00
105_S108_L1.0681.00
61_N174_S1.0651.00
66_A106_S1.0641.00
30_A179_Y1.0641.00
59_V77_A1.0641.00
62_L106_S1.0641.00
66_A171_T1.0631.00
60_D135_G1.0501.00
116_N124_M1.0491.00
68_E105_S1.0311.00
58_K178_Y1.0311.00
146_E149_R1.0271.00
55_W140_E1.0221.00
123_R151_A1.0091.00
108_L112_T1.0021.00
69_R112_T0.9991.00
59_V78_A0.9991.00
62_L131_P0.9831.00
118_Y170_N0.9821.00
80_V182_I0.9821.00
83_V161_G0.9661.00
148_Y154_E0.9561.00
5_P37_S0.9551.00
47_L159_I0.9451.00
52_I143_N0.9451.00
45_I159_I0.9371.00
65_G173_S0.9361.00
58_K137_W0.9341.00
10_G13_P0.9311.00
94_F97_T0.9271.00
145_A155_E0.9261.00
47_L50_T0.9191.00
46_D51_P0.9081.00
168_S175_A0.9041.00
130_G133_K0.9031.00
63_P173_S0.8971.00
113_V123_R0.8931.00
6_L40_V0.8881.00
22_D25_R0.8781.00
76_Y79_R0.8781.00
15_T32_S0.8751.00
15_T30_A0.8751.00
32_S35_S0.8731.00
68_E76_Y0.8631.00
59_V177_A0.8631.00
68_E103_V0.8621.00
81_Y101_N0.8601.00
53_L142_R0.8541.00
45_I50_T0.8541.00
145_A156_P0.8541.00
116_N122_V0.8491.00
109_P129_S0.8451.00
111_G150_R0.8451.00
7_T10_G0.8421.00
125_I142_R0.8231.00
76_Y103_V0.8231.00
46_D158_R0.8221.00
91_L96_R0.8171.00
105_S126_V0.8161.00
102_Y142_R0.8151.00
110_V129_S0.8141.00
36_A165_M0.8111.00
61_N134_L0.8111.00
76_Y117_P0.8101.00
20_V27_V0.7941.00
131_P134_L0.7911.00
64_A173_S0.7901.00
63_P106_S0.7891.00
21_E25_R0.7871.00
123_R152_F0.7851.00
69_R114_I0.7821.00
103_V124_M0.7791.00
101_N122_V0.7771.00
48_K157_P0.7751.00
71_K117_P0.7741.00
73_G118_Y0.7731.00
91_L95_E0.7691.00
19_L28_L0.7641.00
39_L164_I0.7631.00
59_V134_L0.7601.00
61_N64_A0.7551.00
47_L51_P0.7541.00
44_D85_D0.7541.00
104_W130_G0.7491.00
71_K118_Y0.7361.00
53_L80_V0.7341.00
93_F96_R0.7331.00
61_N176_E0.7321.00
92_P96_R0.7321.00
15_T35_S0.7261.00
168_S173_S0.7231.00
13_P33_D0.7181.00
40_V83_V0.7141.00
32_S166_T0.7141.00
148_Y156_P0.7101.00
6_L10_G0.7091.00
95_E121_R0.7081.00
79_R101_N0.7071.00
74_D116_N0.7061.00
47_L144_V0.6961.00
98_R154_E0.6951.00
71_K116_N0.6860.99
126_V129_S0.6860.99
68_E108_L0.6810.99
67_D107_R0.6780.99
164_I179_Y0.6750.99
145_A148_Y0.6750.99
111_G126_V0.6680.99
30_A177_A0.6650.99
115_P120_D0.6640.99
8_F12_K0.6630.99
48_K155_E0.6550.99
99_A122_V0.6530.99
90_R94_F0.6510.99
90_R154_E0.6510.99
13_P34_G0.6480.99
110_V132_A0.6450.99
68_E74_D0.6440.99
68_E106_S0.6320.99
104_W128_R0.6320.99
76_Y106_S0.6270.99
63_P175_A0.6270.99
108_L114_I0.6240.99
38_G83_V0.6140.99
87_D90_R0.6080.99
103_V126_V0.6080.99
66_A76_Y0.6080.99
84_F156_P0.6060.99
104_W140_E0.6050.99
44_D160_V0.6010.99
2_G41_R0.5980.99
76_Y114_I0.5940.99
30_A37_S0.5890.98
86_G154_E0.5890.98
125_I150_R0.5850.98
75_D169_D0.5840.98
171_T175_A0.5790.98
26_R136_Q0.5780.98
45_I144_V0.5740.98
95_E98_R0.5720.98
84_F159_I0.5700.98
85_D158_R0.5680.98
93_F97_T0.5660.98
8_F38_G0.5600.98
164_I182_I0.5590.98
43_V159_I0.5580.98
22_D178_Y0.5570.98
40_V161_G0.5560.98
81_Y165_M0.5540.98
83_V163_A0.5510.98
148_Y152_F0.5490.98
17_Y179_Y0.5470.98
53_L144_V0.5460.98
83_V160_V0.5450.97
66_A73_G0.5450.97
12_K36_A0.5440.97
45_I51_P0.5440.97
165_M179_Y0.5420.97
32_S63_P0.5410.97
9_P13_P0.5390.97
103_V114_I0.5380.97
76_Y124_M0.5380.97
79_R165_M0.5380.97
25_R181_D0.5380.97
50_T143_N0.5380.97
58_K135_G0.5380.97
91_L94_F0.5380.97
110_V128_R0.5370.97
139_T181_D0.5370.97
80_V140_E0.5330.97
15_T37_S0.5300.97
110_V126_V0.5240.97
38_G41_R0.5240.97
46_D50_T0.5240.97
76_Y101_N0.5240.97
2_G42_E0.5230.97
6_L9_P0.5200.97
64_A131_P0.5190.97
92_P97_T0.5180.97
148_Y157_P0.5170.97
85_D159_I0.5170.97
111_G129_S0.5160.97
32_S175_A0.5160.97
48_K51_P0.5160.97
37_S165_M0.5160.97
42_E161_G0.5150.96
86_G90_R0.5140.96
165_M170_N0.5140.96
6_L38_G0.5070.96
61_N175_A0.5030.96
5_P9_P0.5030.96
95_E120_D0.5020.96
82_V102_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vtfA 1 0.694 21.8 0.934 Contact Map
3hbkA 1 0.8142 21 0.934 Contact Map
4qhzA 3 0.7705 15.9 0.938 Contact Map
3u1xA 2 0.7869 12.5 0.941 Contact Map
1l8wA 2 0.2732 12 0.941 Contact Map
3h3lA 2 0.8087 10.8 0.942 Contact Map
3osdA 1 0.8087 9.7 0.943 Contact Map
4jqtA 2 0.7814 8.2 0.945 Contact Map
3immA 1 0.765 7.1 0.947 Contact Map
3s5qA 1 0.765 7 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.