GREMLIN Database
DUF3046 - Protein of unknown function (DUF3046)
PFAM: PF11248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (61)
Sequences: 3453 (1689)
Seq/√Len: 216.3
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_R37_D3.0581.00
11_E20_R2.6051.00
34_R42_A2.5901.00
11_E16_P2.4851.00
26_H56_A2.4391.00
37_D41_A2.2591.00
30_E55_A2.0431.00
44_V48_D1.8731.00
21_S25_D1.7681.00
22_L57_F1.7451.00
10_M19_A1.6641.00
40_L46_P1.5791.00
20_R37_D1.5451.00
7_W23_A1.4721.00
26_H57_F1.4231.00
8_E12_E1.3761.00
38_Q42_A1.3581.00
10_M23_A1.3031.00
11_E19_A1.2931.00
51_R55_A1.2751.00
14_F57_F1.2481.00
7_W37_D1.2451.00
30_E56_A1.2281.00
10_M53_V1.1871.00
14_F22_L1.1021.00
34_R44_V1.1001.00
5_E9_R1.0741.00
54_C59_V1.0591.00
6_F10_M1.0311.00
27_V33_G1.0291.00
5_E8_E1.0261.00
22_L26_H1.0191.00
30_E52_A1.0041.00
45_D48_D0.9921.00
3_L7_W0.9841.00
3_L46_P0.9841.00
23_A36_V0.9611.00
48_D51_R0.9381.00
10_M36_V0.9290.99
23_A37_D0.9160.99
27_V34_R0.8890.99
29_A33_G0.8860.99
7_W20_R0.8800.99
13_E59_V0.8680.99
34_R38_Q0.8490.99
13_E22_L0.8240.99
25_D45_D0.8010.98
47_K51_R0.7960.98
46_P49_V0.7940.98
13_E54_C0.7600.98
20_R24_R0.7530.98
36_V53_V0.7440.97
24_R27_V0.7200.97
18_Y22_L0.7160.97
28_L53_V0.7150.97
52_A55_A0.7110.97
3_L49_V0.6970.96
6_F36_V0.6920.96
7_W11_E0.6890.96
40_L49_V0.6790.96
31_L39_A0.6570.95
29_A56_A0.6560.95
7_W49_V0.6520.95
25_D38_Q0.6420.94
32_G44_V0.6350.94
34_R39_A0.6300.94
31_L44_V0.6050.92
55_A61_A0.5990.92
6_F23_A0.5950.92
14_F59_V0.5950.92
21_S57_F0.5930.91
27_V32_G0.5900.91
3_L6_F0.5860.91
9_R46_P0.5810.91
10_M47_K0.5800.90
8_E11_E0.5660.89
28_L56_A0.5590.89
28_L36_V0.5570.89
13_E61_A0.5550.88
19_A53_V0.5550.88
9_R45_D0.5440.87
53_V59_V0.5440.87
18_Y26_H0.5400.87
3_L40_L0.5350.87
22_L54_C0.5350.87
18_Y28_L0.5330.86
39_A49_V0.5330.86
8_E16_P0.5300.86
28_L31_L0.5230.85
7_W18_Y0.5180.85
3_L14_F0.5070.84
6_F46_P0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ee8A 2 0.9839 29 0.868 Contact Map
4mb7A 2 0.9677 21.5 0.876 Contact Map
4ls6A 2 0.5806 19.7 0.878 Contact Map
3w0fA 1 1 18.2 0.88 Contact Map
2vz8A 2 0.5645 16.3 0.883 Contact Map
2ix4A 2 0.5484 16.2 0.883 Contact Map
2vbaA 2 0.5645 15.5 0.884 Contact Map
4ewgA 2 0.5806 15 0.885 Contact Map
1j3nA 3 0.5645 14.4 0.885 Contact Map
2iwzA 2 0.6774 13.9 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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