GREMLIN Database
Phage_gp53 - Base plate wedge protein 53
PFAM: PF11246 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 189 (173)
Sequences: 1237 (1096)
Seq/√Len: 83.4
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_L167_K3.9691.00
101_I104_Y3.5301.00
45_E53_K3.3661.00
50_V64_V2.9271.00
52_E58_P2.9251.00
63_V179_L2.5331.00
54_L173_L2.5011.00
47_P65_L2.3141.00
102_H105_E2.1941.00
38_K172_Y2.0631.00
159_E163_E1.9421.00
101_I105_E1.8771.00
25_L29_D1.8741.00
27_L31_L1.8651.00
64_V173_L1.8441.00
122_P125_I1.8421.00
155_V158_Y1.7961.00
84_L88_I1.7581.00
51_A57_D1.7521.00
47_P77_W1.7491.00
105_E108_E1.7291.00
57_D60_L1.6981.00
46_R61_D1.6851.00
18_N22_R1.6701.00
121_N124_V1.6651.00
80_S83_D1.6321.00
48_D61_D1.6231.00
27_L30_I1.6171.00
134_T137_D1.5821.00
106_T109_G1.5761.00
158_Y162_T1.5721.00
130_D133_N1.5230.99
30_I34_F1.5170.99
29_D35_T1.5010.99
110_R113_Y1.4950.99
100_T103_H1.4720.99
124_V127_D1.4560.99
92_Y161_E1.4520.99
40_T170_N1.4440.99
103_H106_T1.4230.99
25_L28_D1.4210.99
46_R49_T1.4010.99
29_D32_N1.3960.99
125_I128_K1.3720.99
29_D36_F1.3700.99
115_L118_V1.3590.99
29_D34_F1.3540.99
27_L34_F1.3530.99
25_L31_L1.3460.99
110_R114_N1.3430.99
94_S97_G1.3330.99
132_S135_Y1.3110.98
174_L182_F1.3070.98
111_D114_N1.2940.98
17_K20_F1.2830.98
67_T174_L1.2680.98
54_L176_P1.2560.98
31_L34_F1.2510.98
82_Y86_K1.2410.98
51_A60_L1.2340.98
27_L32_N1.2280.98
128_K131_V1.2270.98
166_E169_R1.2170.98
105_E109_G1.2130.97
45_E49_T1.2120.97
118_V121_N1.2090.97
132_S136_P1.1910.97
127_D130_D1.1910.97
25_L32_N1.1900.97
28_D31_L1.1850.97
65_L73_P1.1840.97
26_R29_D1.1810.97
148_Y151_I1.1810.97
32_N35_T1.1780.97
93_G97_G1.1780.97
106_T111_D1.1710.97
29_D33_A1.1670.97
71_I76_D1.1420.96
129_G132_S1.1420.96
70_I77_W1.1170.96
128_K132_S1.1120.96
156_T159_E1.1110.96
127_D131_V1.0990.95
31_L35_T1.0940.95
133_N136_P1.0770.95
159_E162_T1.0710.95
42_K45_E1.0700.95
126_Y129_G1.0670.95
119_P122_P1.0600.94
25_L34_F1.0580.94
30_I33_A1.0560.94
79_L83_D1.0490.94
93_G96_E1.0460.94
133_N137_D1.0280.94
155_V159_E1.0270.93
87_Y91_K1.0190.93
147_L150_G1.0190.93
125_I129_G1.0050.93
30_I35_T1.0010.93
42_K53_K0.9930.92
43_D81_Q0.9850.92
86_K89_E0.9830.92
102_H106_T0.9820.92
139_G142_D0.9800.92
107_E110_R0.9790.92
85_Y88_I0.9660.91
38_K170_N0.9630.91
109_G112_Y0.9620.91
64_V67_T0.9390.90
109_G113_Y0.9390.90
143_Y146_V0.9390.90
26_R32_N0.9280.89
19_I23_V0.9270.89
27_L36_F0.9250.89
26_R30_I0.9220.89
182_F186_F0.9140.89
131_V134_T0.9120.89
122_P127_D0.9110.89
98_A101_I0.9020.88
100_T104_Y0.9010.88
63_V174_L0.8990.88
51_A64_V0.8910.87
79_L84_L0.8900.87
44_G49_T0.8850.87
84_L87_Y0.8720.86
31_L36_F0.8680.86
99_N104_Y0.8680.86
131_V137_D0.8640.86
70_I76_D0.8600.86
60_L179_L0.8520.85
150_G153_I0.8490.85
60_L183_I0.8440.85
24_K27_L0.8400.84
65_L77_W0.8260.83
131_V135_Y0.8230.83
164_L168_K0.8200.83
108_E111_D0.8140.82
76_D168_K0.8030.81
84_L165_N0.7980.81
130_D134_T0.7930.81
119_P123_T0.7870.80
60_L63_V0.7830.80
112_Y117_E0.7770.79
81_Q84_L0.7750.79
89_E93_G0.7730.79
120_D123_T0.7690.79
124_V128_K0.7690.79
106_T113_Y0.7670.78
139_G143_Y0.7650.78
114_N117_E0.7600.78
16_V22_R0.7590.78
163_E167_K0.7560.77
98_A103_H0.7530.77
117_E120_D0.7450.76
118_V122_P0.7360.75
79_L87_Y0.7330.75
148_Y152_V0.7320.75
27_L33_A0.7300.75
89_E94_S0.7280.75
52_E56_G0.7240.74
14_V17_K0.7240.74
87_Y92_Y0.7210.74
25_L30_I0.7130.73
65_L76_D0.7110.73
111_D116_I0.7080.73
180_Q185_D0.6980.72
62_W68_N0.6970.71
141_D144_T0.6910.71
99_N103_H0.6910.71
27_L35_T0.6890.71
121_N125_I0.6890.71
46_R60_L0.6850.70
16_V19_I0.6830.70
129_G135_Y0.6810.70
143_Y148_Y0.6810.70
154_P158_Y0.6790.69
126_Y132_S0.6790.69
101_I106_T0.6780.69
39_Y45_E0.6760.69
111_D117_E0.6740.69
61_D66_L0.6640.68
30_I36_F0.6620.68
50_V54_L0.6620.68
154_P157_N0.6620.68
150_G157_N0.6610.67
23_V26_R0.6580.67
106_T112_Y0.6580.67
106_T110_R0.6540.67
167_K170_N0.6480.66
89_E95_E0.6450.66
97_G100_T0.6450.66
119_P124_V0.6410.65
54_L75_Y0.6360.64
117_E122_P0.6310.64
126_Y131_V0.6270.63
94_S98_A0.6250.63
107_E112_Y0.6180.62
165_N168_K0.6180.62
113_Y117_E0.6180.62
151_I154_P0.6110.61
41_I77_W0.6100.61
91_K161_E0.6070.61
26_R34_F0.6060.61
50_V53_K0.6040.60
127_D133_N0.6040.60
48_D72_N0.6030.60
28_D33_A0.5960.59
133_N138_V0.5950.59
66_L72_N0.5940.59
138_V143_Y0.5930.59
121_N127_D0.5930.59
20_F61_D0.5920.59
42_K50_V0.5910.59
100_T105_E0.5900.59
71_I170_N0.5850.58
88_I158_Y0.5850.58
63_V67_T0.5840.58
115_L119_P0.5840.58
114_N118_V0.5820.58
25_L36_F0.5740.57
107_E114_N0.5740.57
102_H107_E0.5710.56
81_Q162_T0.5690.56
22_R25_L0.5660.56
102_H157_N0.5640.55
142_D146_V0.5630.55
127_D132_S0.5620.55
120_D125_I0.5600.55
103_H107_E0.5540.54
88_I157_N0.5520.54
89_E98_A0.5520.54
65_L70_I0.5510.54
128_K133_N0.5490.53
110_R116_I0.5490.53
28_D34_F0.5410.52
21_R24_K0.5400.52
104_Y107_E0.5380.52
122_P128_K0.5340.51
155_V163_E0.5300.51
146_V150_G0.5280.51
145_T148_Y0.5270.50
72_N172_Y0.5260.50
108_E114_N0.5260.50
112_Y115_L0.5260.50
105_E110_R0.5200.50
91_K157_N0.5180.49
144_T149_N0.5180.49
127_D135_Y0.5130.49
108_E112_Y0.5120.48
98_A104_Y0.5080.48
72_N75_Y0.5070.48
45_E80_S0.5060.48
157_N163_E0.5050.48
43_D169_R0.5050.48
19_I22_R0.5050.48
180_Q184_N0.5050.48
132_S137_D0.5040.47
20_F24_K0.5020.47
136_P144_T0.5010.47
104_Y108_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ltfA 1 0.3545 90.2 0.909 Contact Map
4pxvA 1 0.254 12.1 0.953 Contact Map
3mujA 2 0.2593 4.5 0.961 Contact Map
3otdA 4 0.2593 3.2 0.964 Contact Map
1e0gA 1 0.254 3 0.965 Contact Map
3fwbB 1 0.1481 2.4 0.966 Contact Map
3hvzA 2 0.328 2.4 0.966 Contact Map
1ujlA 1 0.2222 2.2 0.967 Contact Map
2fgcA 2 0.3386 2.2 0.967 Contact Map
2mkxA 1 0.2698 2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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