GREMLIN Database
DUF3043 - Protein of unknown function (DUF3043)
PFAM: PF11241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (169)
Sequences: 2951 (1907)
Seq/√Len: 146.7
META: 0.732

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R166_Q3.7781.00
37_R41_R3.0351.00
46_E50_A2.6261.00
82_F86_A2.6031.00
53_E66_R2.5401.00
25_D28_E2.4591.00
8_K11_E2.4201.00
47_A50_A2.3351.00
26_R30_R2.2461.00
70_D166_Q2.2401.00
45_R49_A2.2331.00
68_V150_A2.1711.00
128_R132_L2.1441.00
132_L135_E2.0001.00
28_E32_R1.9111.00
76_R169_R1.9011.00
42_A46_E1.8741.00
68_V146_L1.8681.00
168_K171_D1.8601.00
25_D29_A1.8431.00
132_L136_R1.8341.00
147_G151_A1.7751.00
39_A43_R1.7491.00
67_F132_L1.7411.00
76_R81_F1.7311.00
71_Y128_R1.7061.00
10_K13_E1.7051.00
47_A55_Y1.6531.00
67_F137_F1.6511.00
77_N121_D1.6091.00
81_F84_P1.5981.00
35_E39_A1.5961.00
129_L150_A1.5851.00
22_A25_D1.5651.00
129_L133_V1.5441.00
36_A39_A1.5311.00
99_P104_Q1.5091.00
133_V146_L1.4841.00
40_A44_Q1.4411.00
126_G147_G1.4161.00
28_E31_K1.3961.00
1_G4_R1.3911.00
157_M160_L1.3731.00
77_N125_L1.3721.00
123_V127_R1.3711.00
35_E38_R1.3671.00
87_L90_L1.3591.00
105_L109_L1.3441.00
18_R21_K1.3311.00
13_E16_R1.3161.00
67_F71_Y1.2851.00
64_V143_T1.2761.00
32_R36_A1.2671.00
40_A43_R1.2551.00
13_E17_R1.2521.00
113_V117_V1.2511.00
86_A90_L1.2461.00
48_M162_L1.2461.00
138_P142_S1.2301.00
109_L113_V1.2261.00
87_L91_V1.2131.00
120_V124_L1.1961.00
53_E61_R1.1761.00
127_R131_R1.1731.00
36_A40_A1.1701.00
32_R35_E1.1571.00
128_R131_R1.1471.00
64_V141_E1.1360.99
26_R29_A1.1280.99
65_R146_L1.1250.99
130_K134_A1.1170.99
41_R44_Q1.1150.99
15_A19_P1.1120.99
100_N103_V1.1100.99
84_P88_V1.1100.99
125_L154_A1.1050.99
22_A26_R1.1000.99
15_A18_R1.0940.99
39_A42_A1.0930.99
50_A55_Y1.0840.99
27_K30_R1.0810.99
152_M155_L1.0670.99
43_R55_Y1.0640.99
2_K5_P1.0640.99
33_A37_R1.0610.99
124_L128_R1.0560.99
48_M57_P1.0530.99
147_G150_A1.0450.99
34_R38_R1.0420.99
106_Y110_L1.0390.99
22_A32_R1.0300.99
101_P104_Q1.0260.99
64_V133_V1.0250.99
25_D31_K1.0190.99
152_M156_Q1.0060.99
27_K33_A1.0030.99
122_G155_L0.9800.98
138_P143_T0.9790.98
95_L98_V0.9630.98
83_L87_L0.9530.98
124_L127_R0.9520.98
37_R40_A0.9510.98
58_A61_R0.9510.98
62_G66_R0.9430.98
52_D55_Y0.9370.98
23_P26_R0.9320.98
108_S112_L0.9310.98
112_L116_L0.9250.98
74_S77_N0.9210.98
46_E49_A0.9200.98
49_A164_K0.9130.98
89_V111_M0.9110.98
71_Y129_L0.8990.97
167_V170_G0.8990.97
116_L120_V0.8990.97
10_K14_A0.8860.97
2_K6_T0.8850.97
130_K147_G0.8730.97
68_V133_V0.8680.97
121_D125_L0.8650.97
82_F118_V0.8580.96
142_S145_G0.8560.96
134_A143_T0.8550.96
138_P141_E0.8490.96
44_Q47_A0.8360.96
22_A27_K0.8320.96
100_N104_Q0.8310.96
133_V147_G0.8220.95
34_R37_R0.8170.95
25_D32_R0.8170.95
126_G151_A0.8170.95
30_R33_A0.8090.95
143_T146_L0.8050.95
43_R47_A0.8040.95
156_Q160_L0.7960.95
23_P29_A0.7850.94
12_A16_R0.7840.94
148_W152_M0.7750.94
141_E144_R0.7680.94
53_E62_G0.7670.93
78_V117_V0.7620.93
141_E145_G0.7620.93
55_Y61_R0.7600.93
107_A110_L0.7600.93
119_V123_V0.7560.93
98_V103_V0.7540.93
77_N154_A0.7540.93
160_L164_K0.7530.93
8_K12_A0.7440.92
103_V106_Y0.7400.92
23_P28_E0.7390.92
29_A32_R0.7390.92
126_G130_K0.7320.92
79_G121_D0.7240.91
80_E169_R0.7230.91
38_R42_A0.7190.91
71_Y132_L0.7190.91
13_E18_R0.7130.91
4_R11_E0.7090.90
22_A29_A0.7080.90
92_L107_A0.7060.90
78_V85_L0.7060.90
89_V107_A0.7030.90
72_V125_L0.7030.90
95_L100_N0.7020.90
67_F136_R0.6970.90
47_A57_P0.6970.90
74_S132_L0.6890.89
19_P22_A0.6880.89
127_R134_A0.6860.89
109_L116_L0.6840.89
88_V92_L0.6800.89
52_D56_L0.6790.89
64_V67_F0.6780.88
68_V137_F0.6770.88
24_A28_E0.6760.88
140_D143_T0.6750.88
125_L129_L0.6740.88
44_Q50_A0.6690.88
103_V168_K0.6670.88
134_A138_P0.6590.87
16_R20_L0.6560.87
142_S146_L0.6520.86
71_Y80_E0.6520.86
115_L155_L0.6480.86
38_R41_R0.6480.86
43_R46_E0.6470.86
3_G6_T0.6440.86
2_K9_R0.6430.86
45_R93_T0.6390.85
14_A19_P0.6380.85
27_K31_K0.6360.85
6_T9_R0.6340.85
115_L160_L0.6300.85
23_P27_K0.6280.84
79_G154_A0.6270.84
118_V155_L0.6260.84
152_M160_L0.6260.84
71_Y125_L0.6250.84
53_E56_L0.6240.84
92_L103_V0.6230.84
158_R161_R0.6180.83
49_A162_L0.6090.83
59_R62_G0.6060.82
17_R21_K0.6050.82
99_P103_V0.6050.82
105_L108_S0.6040.82
47_A54_R0.6030.82
102_A106_Y0.6020.82
15_A20_L0.6000.82
30_R34_R0.6000.82
59_R65_R0.5880.80
22_A28_E0.5870.80
90_L114_L0.5870.80
10_K15_A0.5860.80
12_A19_P0.5840.80
127_R135_E0.5840.80
157_M162_L0.5820.80
111_M122_G0.5800.79
59_R154_A0.5780.79
159_R168_K0.5770.79
130_K143_T0.5720.78
126_G129_L0.5690.78
79_G122_G0.5670.78
14_A18_R0.5660.78
76_R170_G0.5660.78
82_F111_M0.5650.78
49_A53_E0.5620.77
77_N80_E0.5620.77
117_V120_V0.5610.77
8_K14_A0.5580.77
127_R159_R0.5560.76
78_V92_L0.5530.76
53_E60_D0.5510.76
24_A31_K0.5490.76
111_M115_L0.5470.75
71_Y74_S0.5410.75
47_A52_D0.5410.75
60_D66_R0.5390.74
18_R22_A0.5340.74
74_S167_V0.5320.73
131_R135_E0.5270.73
50_A54_R0.5240.72
122_G126_G0.5220.72
42_A47_A0.5210.72
119_V148_W0.5190.71
126_G150_A0.5160.71
43_R52_D0.5160.71
100_N107_A0.5140.71
148_W151_A0.5140.71
88_V168_K0.5040.69
44_Q55_Y0.5040.69
154_A157_M0.5020.69
122_G151_A0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jweC 1 0.0585 5.8 0.961 Contact Map
4cylA 1 0 5.5 0.962 Contact Map
1pi7A 1 0.1111 3.9 0.965 Contact Map
1wazA 1 0.2632 3.7 0.965 Contact Map
2m7gA 1 0.3567 3.4 0.965 Contact Map
3uwpA 1 0 3.2 0.966 Contact Map
1mhsA 2 0.7368 2.9 0.967 Contact Map
2f93B 2 0.2105 2.5 0.968 Contact Map
3aaeX 1 0.076 2.5 0.968 Contact Map
2hi2A 1 0.4795 2.3 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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