GREMLIN Database
DUF3038 - Protein of unknown function (DUF3038)
PFAM: PF11237 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (168)
Sequences: 565 (299)
Seq/√Len: 23.1
META: 0.692

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L163_L4.3511.00
31_N36_N2.8470.99
162_R167_L2.7340.99
85_L108_R2.6870.99
37_D79_A2.5150.98
24_E42_R2.3190.97
18_L167_L2.2950.97
52_N58_Y2.2860.97
49_R123_R2.2560.97
69_D164_W2.2280.97
8_L72_V2.1970.96
49_R55_R2.1320.96
55_R123_R2.1010.95
24_E79_A2.0240.94
51_S61_K1.9780.93
87_R112_Y1.9420.93
6_E50_C1.9400.93
75_T99_K1.8940.92
157_T162_R1.8780.91
94_E98_E1.8650.91
53_P123_R1.8630.91
52_N57_S1.8450.91
88_Q92_S1.8350.90
46_W55_R1.8290.90
67_E143_L1.8210.90
140_L144_A1.7660.88
52_N55_R1.7380.88
46_W49_R1.6990.86
84_P88_Q1.6690.85
46_W123_R1.6540.85
2_R6_E1.6390.84
25_A78_L1.5820.82
19_D78_L1.5430.80
45_L61_K1.5340.80
92_S107_A1.5290.80
38_V70_A1.5220.80
112_Y148_L1.4960.78
41_N44_T1.4770.77
55_R124_M1.4750.77
16_E49_R1.4590.77
41_N47_R1.4480.76
2_R19_D1.4270.75
140_L143_L1.4150.74
133_K163_L1.4110.74
150_D154_C1.4000.73
61_K67_E1.3900.73
88_Q108_R1.3810.72
92_S108_R1.3690.72
43_V74_I1.3650.72
159_G162_R1.3150.69
160_Y163_L1.3080.68
98_E102_P1.3060.68
14_A35_L1.3010.68
16_E55_R1.2970.67
49_R52_N1.2910.67
14_A87_R1.2870.67
60_R123_R1.2350.64
42_R60_R1.2230.63
30_A149_L1.2140.62
8_L94_E1.2060.62
14_A112_Y1.2060.62
14_A168_F1.2040.62
58_Y78_L1.1820.60
9_D12_L1.1810.60
92_S106_S1.1800.60
16_E46_W1.1700.59
52_N128_R1.1660.59
9_D159_G1.1650.59
109_L120_I1.1510.58
36_N149_L1.1350.57
52_N125_N1.1270.56
8_L35_L1.1070.55
101_L107_A1.1030.55
52_N119_L1.0950.54
40_P44_T1.0920.54
18_L162_R1.0910.54
103_P163_L1.0910.54
18_L86_I1.0900.54
114_D121_R1.0880.54
22_G25_A1.0820.53
43_V123_R1.0800.53
52_N123_R1.0750.53
58_Y130_R1.0620.52
125_N128_R1.0480.51
102_P105_N1.0450.51
82_L154_C1.0320.50
11_L150_D1.0260.49
92_S101_L1.0170.49
152_L164_W1.0080.48
14_A33_L1.0040.48
84_P92_S0.9940.47
12_L22_G0.9900.47
84_P108_R0.9870.47
115_R156_G0.9860.47
16_E27_L0.9800.46
94_E135_L0.9690.45
143_L153_F0.9570.45
112_Y144_A0.9560.45
32_E40_P0.9520.44
45_L60_R0.9510.44
51_S126_P0.9510.44
74_I105_N0.9240.42
98_E158_G0.9230.42
29_A77_E0.9200.42
22_G30_A0.9060.41
35_L117_R0.9010.41
101_L105_N0.8990.41
116_F144_A0.8950.40
5_K59_G0.8830.40
38_V74_I0.8770.39
17_A25_A0.8740.39
42_R124_M0.8730.39
151_L159_G0.8720.39
120_I143_L0.8700.39
67_E74_I0.8700.39
11_L75_T0.8680.39
85_L94_E0.8610.38
129_S157_T0.8560.38
7_Q43_V0.8540.38
11_L151_L0.8480.37
115_R119_L0.8470.37
53_P124_M0.8410.37
34_G38_V0.8390.37
74_I93_L0.8370.37
6_E54_L0.8370.37
84_P100_Q0.8330.36
6_E78_L0.8290.36
158_G165_L0.8230.36
96_L106_S0.8190.35
75_T132_K0.8190.35
93_L97_E0.8170.35
76_C86_I0.8170.35
69_D168_F0.8120.35
4_I61_K0.8030.34
63_L102_P0.7990.34
23_S27_L0.7980.34
28_A102_P0.7870.33
114_D161_Q0.7820.33
14_A116_F0.7720.32
43_V71_L0.7680.32
47_R152_L0.7660.32
112_Y116_F0.7620.32
9_D16_E0.7610.32
70_A88_Q0.7590.32
11_L74_I0.7590.32
5_K67_E0.7580.32
10_L102_P0.7560.32
70_A92_S0.7540.31
114_D133_K0.7520.31
136_S139_E0.7460.31
116_F155_S0.7400.31
100_Q136_S0.7350.30
9_D13_L0.7240.30
83_Y91_S0.7200.29
27_L42_R0.7200.29
2_R115_R0.7190.29
4_I79_A0.7110.29
85_L88_Q0.7070.29
148_L168_F0.7060.29
82_L115_R0.7000.28
153_F164_W0.6950.28
66_E169_D0.6950.28
110_G141_D0.6950.28
56_K119_L0.6940.28
86_I97_E0.6890.28
29_A73_L0.6860.27
13_L17_A0.6800.27
95_Q109_L0.6800.27
9_D123_R0.6770.27
116_F152_L0.6770.27
52_N156_G0.6760.27
115_R125_N0.6720.27
65_L86_I0.6710.27
16_E43_V0.6700.27
28_A32_E0.6690.27
148_L151_L0.6660.26
107_A158_G0.6660.26
40_P156_G0.6640.26
104_E141_D0.6640.26
51_S59_G0.6630.26
159_G163_L0.6610.26
30_A114_D0.6590.26
62_K132_K0.6570.26
119_L122_E0.6530.26
96_L169_D0.6520.26
88_Q95_Q0.6500.26
164_W168_F0.6310.25
5_K64_D0.6310.25
113_L144_A0.6280.24
73_L94_E0.6270.24
69_D120_I0.6240.24
66_E81_R0.6230.24
13_L16_E0.6230.24
76_C81_R0.6220.24
14_A78_L0.6180.24
71_L87_R0.6140.24
5_K54_L0.6120.24
47_R63_L0.6090.23
21_N26_M0.6040.23
19_D59_G0.6020.23
19_D25_A0.6020.23
59_G130_R0.6010.23
17_A56_K0.5960.23
18_L117_R0.5930.23
144_A152_L0.5920.23
22_G55_R0.5910.23
31_N121_R0.5900.22
12_L45_L0.5900.22
15_L23_S0.5890.22
109_L112_Y0.5870.22
55_R60_R0.5790.22
54_L94_E0.5780.22
28_A103_P0.5760.22
80_K119_L0.5680.21
48_L129_S0.5640.21
18_L27_L0.5600.21
139_E142_E0.5550.21
45_L68_A0.5540.21
13_L81_R0.5520.21
43_V46_W0.5470.20
125_N162_R0.5460.20
100_Q135_L0.5440.20
65_L164_W0.5440.20
91_S145_L0.5410.20
68_A104_E0.5380.20
15_L151_L0.5320.20
23_S45_L0.5310.20
62_K135_L0.5310.20
115_R168_F0.5300.20
52_N115_R0.5290.20
114_D132_K0.5270.20
5_K78_L0.5270.20
9_D53_P0.5250.19
8_L75_T0.5250.19
32_E44_T0.5210.19
78_L93_L0.5200.19
85_L92_S0.5200.19
86_I91_S0.5190.19
42_R45_L0.5170.19
13_L119_L0.5170.19
16_E52_N0.5150.19
56_K73_L0.5140.19
76_C130_R0.5110.19
145_L154_C0.5100.19
95_Q143_L0.5090.19
42_R79_A0.5090.19
101_L106_S0.5080.19
34_G165_L0.5030.19
28_A97_E0.5020.18
76_C169_D0.5010.18
27_L60_R0.5000.18
34_G142_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yczB 1 0.8462 25.5 0.949 Contact Map
4xmmD 1 0.7396 16.1 0.954 Contact Map
1hlvA 1 0.6805 8.1 0.959 Contact Map
3m3wA 2 0.3432 5.1 0.963 Contact Map
4dylA 2 0.3905 4.2 0.964 Contact Map
1fmeA 1 0.1538 4 0.965 Contact Map
3oaoA 2 0.5917 3.9 0.965 Contact Map
1ubyA 2 0.355 3.7 0.966 Contact Map
2cobA 1 0.3491 3.5 0.966 Contact Map
5a29A 2 0.3373 3.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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