GREMLIN Database
DUF3037 - Protein of unknown function (DUF3037)
PFAM: PF11236 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (118)
Sequences: 9395 (6323)
Seq/√Len: 582.1
META: 0.913

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E54_R3.8531.00
33_R111_E3.4721.00
112_R116_R2.6201.00
31_G107_A2.5061.00
6_V18_V2.4901.00
77_P80_E2.2991.00
14_E17_N2.2091.00
58_A61_E2.1201.00
20_V110_L2.1131.00
109_E112_R2.1121.00
61_E65_A2.0151.00
103_C109_E2.0041.00
105_D108_A1.8681.00
5_R15_F1.8281.00
54_R58_A1.8261.00
16_V44_L1.7501.00
34_I61_E1.7481.00
33_R114_F1.7161.00
67_G74_A1.6221.00
29_F106_P1.5981.00
24_C27_R1.5971.00
31_G65_A1.5791.00
38_E42_R1.5501.00
27_R106_P1.4751.00
107_A111_E1.4731.00
39_A42_R1.4481.00
114_F118_V1.4331.00
42_R50_L1.4211.00
2_A86_V1.4131.00
79_R83_R1.4081.00
22_L110_L1.3491.00
7_V94_Q1.3301.00
86_V98_V1.3181.00
72_P75_A1.2901.00
68_P75_A1.2461.00
28_G78_L1.2421.00
25_P79_R1.2311.00
48_L53_V1.2251.00
49_D52_A1.2131.00
20_V113_L1.2121.00
88_P97_P1.2071.00
32_A61_E1.2061.00
31_G61_E1.1901.00
18_V57_L1.1861.00
59_A63_I1.1831.00
6_V41_L1.1791.00
6_V53_V1.1751.00
76_L80_E1.1651.00
62_R67_G1.1561.00
70_A74_A1.1511.00
39_A43_A1.1411.00
111_E115_E1.1341.00
16_V41_L1.1121.00
22_L109_E1.0951.00
50_L54_R1.0941.00
13_G99_H1.0901.00
60_I95_T1.0771.00
14_E40_R1.0771.00
31_G110_L1.0711.00
56_H59_A1.0521.00
52_A55_A1.0321.00
71_G74_A1.0211.00
35_E114_F1.0071.00
86_V89_R1.0021.00
10_V94_Q0.9961.00
58_A62_R0.9951.00
51_E54_R0.9941.00
24_C29_F0.9781.00
23_F79_R0.9741.00
113_L117_L0.9671.00
53_V57_L0.9571.00
3_V20_V0.9421.00
9_R12_R0.9391.00
80_E83_R0.9371.00
5_R94_Q0.9361.00
16_V40_R0.9301.00
63_I66_G0.9231.00
85_L89_R0.9171.00
22_L106_P0.9051.00
25_P77_P0.8811.00
62_R69_A0.8811.00
38_E50_L0.8751.00
29_F107_A0.8641.00
52_A56_H0.8581.00
32_A64_C0.8561.00
40_R44_L0.8561.00
89_R95_T0.8531.00
41_L48_L0.8531.00
83_R87_A0.8421.00
108_A112_R0.8381.00
103_C106_P0.8241.00
32_A60_I0.8231.00
62_R65_A0.8211.00
84_W87_A0.8201.00
5_R17_N0.8121.00
4_L95_T0.8091.00
101_G109_E0.8071.00
73_I76_L0.8051.00
23_F78_L0.8011.00
38_E51_E0.7751.00
55_A58_A0.7621.00
70_A73_I0.7611.00
104_D109_E0.7461.00
103_C108_A0.7361.00
108_A111_E0.7341.00
22_L29_F0.7261.00
23_F83_R0.7231.00
72_P76_L0.7181.00
55_A59_A0.7181.00
40_R43_A0.7121.00
5_R13_G0.7121.00
23_F30_L0.7091.00
88_P91_T0.7051.00
41_L53_V0.7031.00
9_R45_D0.6981.00
42_R48_L0.6921.00
3_V17_N0.6871.00
82_F98_V0.6821.00
67_G70_A0.6791.00
13_G97_P0.6771.00
42_R45_D0.6721.00
109_E113_L0.6711.00
29_F110_L0.6701.00
33_R110_L0.6691.00
45_D48_L0.6641.00
18_V48_L0.6571.00
36_L54_R0.6511.00
25_P28_G0.6371.00
1_Y117_L0.6351.00
55_A62_R0.6321.00
2_A6_V0.6271.00
51_E55_A0.6251.00
4_L60_I0.6201.00
57_L61_E0.6171.00
59_A62_R0.6161.00
26_E79_R0.6151.00
110_L114_F0.6111.00
25_P80_E0.6001.00
2_A96_S0.5991.00
107_A115_E0.5971.00
100_T103_C0.5871.00
21_I32_A0.5791.00
104_D108_A0.5791.00
68_P71_G0.5781.00
56_H63_I0.5751.00
4_L21_I0.5741.00
112_R115_E0.5741.00
12_R15_F0.5711.00
10_V13_G0.5661.00
83_R86_V0.5650.99
50_L53_V0.5620.99
21_I95_T0.5600.99
2_A82_F0.5570.99
80_E84_W0.5570.99
19_G34_I0.5570.99
62_R70_A0.5560.99
7_V13_G0.5550.99
21_I30_L0.5540.99
106_P109_E0.5530.99
8_P44_L0.5530.99
52_A92_V0.5520.99
109_E114_F0.5410.99
67_G71_G0.5320.99
1_Y99_H0.5300.99
68_P72_P0.5290.99
4_L34_I0.5220.99
3_V117_L0.5210.99
15_F44_L0.5200.99
67_G75_A0.5190.99
6_V48_L0.5190.99
109_E116_R0.5170.99
19_G114_F0.5160.99
12_R90_S0.5150.99
49_D53_V0.5140.99
114_F117_L0.5080.99
49_D56_H0.5010.99
42_R46_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lj8A 1 0.6271 7.2 0.907 Contact Map
4mfuA 2 0.5254 6.9 0.908 Contact Map
1cnuA 1 0.6017 6.7 0.909 Contact Map
4uzzB 1 0.5 6.3 0.91 Contact Map
4lizA 1 0.6356 5.1 0.914 Contact Map
2xfaA 1 0.6271 4.7 0.915 Contact Map
4bex1 2 0.7119 4.6 0.916 Contact Map
2i2qA 1 0.5085 4.6 0.916 Contact Map
3silA 1 0.3475 4.4 0.917 Contact Map
4c5pA 1 0.4915 4.3 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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