GREMLIN Database
DUF3035 - Protein of unknown function (DUF3035)
PFAM: PF11233 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 153 (147)
Sequences: 2603 (1964)
Seq/√Len: 162.0
META: 0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_E141_R4.6261.00
101_T105_E3.6581.00
37_D40_L3.5601.00
45_T48_A3.0621.00
139_A143_R2.8521.00
134_D137_A2.8411.00
34_M38_Y2.8161.00
142_L147_A2.3241.00
10_T14_L2.1521.00
97_N100_Q2.1401.00
137_A140_E2.0811.00
12_R17_T2.0801.00
55_T58_A2.0431.00
140_E144_E2.0321.00
140_E143_R2.0181.00
97_N101_T1.9231.00
138_E142_L1.9051.00
95_D101_T1.9031.00
50_R53_E1.8281.00
84_A88_K1.8211.00
145_N150_P1.8171.00
79_S82_E1.7841.00
144_E148_L1.7791.00
11_R17_T1.7471.00
38_Y41_R1.7041.00
47_G50_R1.6461.00
100_Q104_A1.6171.00
54_L59_Q1.6011.00
56_P59_Q1.5481.00
15_G18_K1.5141.00
106_D109_L1.5121.00
11_R16_L1.5101.00
80_A84_A1.5081.00
9_S12_R1.5041.00
142_L146_G1.5031.00
56_P60_A1.4851.00
29_R33_S1.4571.00
2_A5_G1.4291.00
33_S51_P1.4121.00
46_P50_R1.4081.00
81_G85_L1.3911.00
141_R145_N1.3881.00
13_A18_K1.3771.00
145_N148_L1.3751.00
103_D106_D1.3711.00
80_A83_Q1.3561.00
117_T120_L1.3341.00
136_A140_E1.3061.00
145_N149_G1.2871.00
65_G68_P1.2731.00
68_P72_A1.2651.00
10_T13_A1.2441.00
36_P40_L1.2321.00
86_L89_A1.2271.00
56_P63_A1.2201.00
46_P49_P1.2171.00
136_A139_A1.2111.00
98_I101_T1.2011.00
106_D110_R1.1931.00
83_Q87_A1.1791.00
109_L113_D1.1651.00
11_R14_L1.1461.00
132_V135_A1.1401.00
27_V82_E1.1081.00
86_L91_A1.1011.00
37_D41_R1.0861.00
142_L145_N1.0820.99
104_A108_A1.0790.99
10_T16_L1.0580.99
109_L112_K1.0550.99
108_A111_R1.0520.99
61_R65_G1.0520.99
114_R118_D1.0370.99
60_A63_A1.0320.99
61_R71_A1.0180.99
11_R15_G0.9950.99
5_G13_A0.9930.99
90_G99_R0.9690.99
116_F120_L0.9680.99
55_T59_Q0.9540.99
69_A72_A0.9370.99
29_R52_Q0.9320.98
113_D117_T0.9140.98
10_T15_G0.8980.98
140_E148_L0.8960.98
67_N70_A0.8900.98
82_E89_A0.8890.98
46_P52_Q0.8880.98
118_D123_W0.8800.98
21_P24_F0.8800.98
145_N151_S0.8690.98
142_L149_G0.8560.97
88_K110_R0.8500.97
81_G84_A0.8480.97
142_L148_L0.8360.97
57_R61_R0.8340.97
12_R19_S0.8110.96
4_A8_S0.8070.96
70_A73_P0.8060.96
58_A61_R0.8030.96
133_L145_N0.8010.96
115_S118_D0.7990.96
21_P47_G0.7980.96
125_D128_P0.7960.96
47_G52_Q0.7900.96
13_A16_L0.7850.96
124_R129_P0.7850.96
119_R126_P0.7800.95
16_L19_S0.7780.95
135_A138_E0.7680.95
85_L88_K0.7680.95
103_D111_R0.7610.95
144_E150_P0.7600.95
11_R28_T0.7560.95
77_G80_A0.7560.95
68_P73_P0.7490.94
36_P41_R0.7460.94
3_L6_C0.7380.94
128_P132_V0.7360.94
30_A59_Q0.7350.94
78_R83_Q0.7340.94
29_R112_K0.7320.94
133_L138_E0.7250.93
82_E86_L0.7170.93
56_P64_L0.7170.93
124_R127_Y0.7140.93
4_A128_P0.7130.93
133_L149_G0.7080.92
146_G149_G0.7080.92
30_A36_P0.6990.92
22_D26_V0.6980.92
32_L35_P0.6880.91
91_A95_D0.6870.91
12_R116_F0.6870.91
133_L146_G0.6710.90
34_M37_D0.6690.90
60_A64_L0.6650.90
12_R15_G0.6590.90
25_A28_T0.6560.89
62_A67_N0.6560.89
133_L150_P0.6550.89
13_A19_S0.6530.89
99_R102_V0.6490.89
55_T71_A0.6470.89
28_T78_R0.6430.88
134_D138_E0.6430.88
130_G140_E0.6410.88
26_V29_R0.6400.88
90_G94_A0.6400.88
143_R148_L0.6370.88
135_A139_A0.6370.88
75_A78_R0.6350.88
30_A135_A0.6350.88
92_D97_N0.6350.88
96_P105_E0.6340.88
70_A77_G0.6260.87
71_A76_G0.6220.87
11_R92_D0.6220.87
102_V106_D0.6170.86
86_L111_R0.6150.86
73_P100_Q0.6120.86
86_L90_G0.6060.85
64_L67_N0.6040.85
13_A20_A0.5990.85
113_D116_F0.5960.84
118_D121_L0.5900.84
30_A34_M0.5900.84
6_C35_P0.5900.84
148_L151_S0.5860.83
62_A65_G0.5800.83
93_G110_R0.5770.82
100_Q111_R0.5760.82
55_T67_N0.5760.82
116_F122_F0.5740.82
113_D119_R0.5720.82
116_F119_R0.5680.81
77_G110_R0.5670.81
21_P44_P0.5660.81
143_R149_G0.5660.81
137_A150_P0.5650.81
29_R34_M0.5650.81
25_A137_A0.5650.81
15_G19_S0.5630.81
88_K92_D0.5590.80
113_D135_A0.5530.80
132_V145_N0.5510.79
69_A73_P0.5490.79
11_R98_I0.5440.79
26_V139_A0.5440.79
104_A110_R0.5420.78
46_P53_E0.5410.78
104_A107_A0.5380.78
115_S126_P0.5380.78
44_P47_G0.5370.78
9_S13_A0.5350.77
47_G60_A0.5340.77
34_M53_E0.5290.77
86_L142_L0.5290.77
46_P51_P0.5290.77
22_D25_A0.5280.76
39_N84_A0.5270.76
51_P103_D0.5240.76
114_R119_R0.5210.76
4_A73_P0.5210.76
109_L131_Q0.5200.75
95_D134_D0.5190.75
15_G123_W0.5170.75
63_A67_N0.5150.75
82_E142_L0.5130.74
72_A82_E0.5130.74
118_D122_F0.5110.74
12_R16_L0.5110.74
139_A147_A0.5100.74
13_A17_T0.5060.73
87_A129_P0.5050.73
100_Q107_A0.5040.73
107_A110_R0.5020.73
78_R110_R0.5020.73
46_P63_A0.5000.73
79_S90_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tgoC 2 0.8235 56 0.903 Contact Map
3zbiC 1 0.183 10.3 0.933 Contact Map
3df0C 1 0.2288 7.8 0.937 Contact Map
4cbhA 1 0.5294 5.2 0.942 Contact Map
4p5wA 2 0.1765 5.2 0.942 Contact Map
2cmeA 2 0.1961 3.9 0.945 Contact Map
3tu5B 1 0 2.2 0.952 Contact Map
2gtvX 1 0.4052 1.7 0.955 Contact Map
1j8bA 2 0.1765 1.7 0.955 Contact Map
1th8B 1 0.2549 1.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.