GREMLIN Database
DUF3034 - Protein of unknown function (DUF3034)
PFAM: PF11231 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (257)
Sequences: 1203 (839)
Seq/√Len: 52.3
META: 0.796

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_V94_V4.4671.00
170_F220_W4.3741.00
164_A183_Y4.1581.00
158_L191_A4.1221.00
97_A111_V3.8861.00
11_A20_V3.8341.00
136_G166_K3.8291.00
117_Y137_T3.6781.00
192_A200_A3.5681.00
205_Y219_D3.3761.00
147_F158_L3.2571.00
96_L141_L2.9921.00
165_T186_Q2.9861.00
208_K217_E2.9651.00
22_A52_A2.8921.00
11_A22_A2.8681.00
97_A108_L2.8641.00
21_I54_G2.6801.00
187_F207_Q2.6661.00
96_L113_V2.5821.00
35_F50_G2.4981.00
178_D213_G2.4951.00
166_K183_Y2.4271.00
164_A185_L2.3911.00
113_V141_L2.1531.00
201_V225_V2.1411.00
162_L185_L2.1241.00
241_D252_R2.1181.00
180_N184_S2.0661.00
198_N227_W2.0511.00
126_P131_A2.0261.00
13_G204_E2.0231.00
64_A89_I1.8870.99
65_R88_D1.8840.99
163_R188_E1.8540.99
129_L214_F1.7670.99
194_L200_A1.7260.99
125_V128_A1.7140.99
108_L111_V1.6920.99
92_A115_V1.6710.99
4_V236_T1.6460.98
142_S161_T1.6210.98
62_S91_G1.5910.98
30_I56_F1.5770.98
51_A63_Y1.5130.97
15_L240_V1.5080.97
151_L156_L1.4890.97
57_D95_R1.4830.97
146_L157_L1.4810.97
195_L225_V1.4630.97
30_I55_L1.4510.96
88_D121_D1.4500.96
111_V141_L1.4370.96
237_A256_L1.4200.96
70_T74_G1.4190.96
225_V229_P1.3960.95
38_R47_D1.3870.95
244_N249_R1.3870.95
119_R134_D1.3810.95
20_V100_A1.3810.95
66_Q87_Q1.3760.95
113_V117_Y1.3480.94
63_Y88_D1.3400.94
75_A81_P1.3340.94
36_A49_Y1.3110.94
36_A47_D1.3050.93
142_S159_N1.2820.93
186_Q207_Q1.2720.93
73_L129_L1.2670.92
52_A62_S1.2640.92
221_W241_D1.2630.92
166_K181_D1.2590.92
136_G183_Y1.2570.92
192_A224_F1.2510.92
39_V240_V1.2500.92
117_Y135_S1.2390.92
25_G54_G1.2340.91
63_Y90_F1.2250.91
28_D56_F1.2130.91
166_K182_S1.2120.91
7_I170_F1.2020.90
91_G140_Y1.2000.90
133_D136_G1.1800.89
70_T77_L1.1780.89
103_D106_S1.1780.89
55_L61_L1.1760.89
37_T240_V1.1740.89
39_V46_L1.1640.89
35_F64_A1.1610.89
214_F247_T1.1470.88
186_Q219_D1.1410.88
85_L172_L1.1360.88
235_L258_L1.1360.88
160_A191_A1.1350.88
55_L59_V1.1330.87
59_V92_A1.1040.86
94_V113_V1.0910.85
35_F48_S1.0880.85
88_D119_R1.0870.85
100_A146_L1.0860.85
115_V137_T1.0780.85
80_G83_L1.0670.84
83_L122_D1.0640.84
6_Q16_T1.0500.83
195_L203_A1.0470.83
237_A254_L1.0470.83
116_Q138_D1.0450.83
70_T73_L1.0410.83
65_R121_D1.0380.82
207_Q219_D1.0340.82
63_Y92_A1.0330.82
85_L120_N1.0260.82
102_Y228_F1.0240.82
8_E118_K1.0210.81
189_G207_Q1.0100.81
138_D166_K1.0050.80
67_R84_T1.0030.80
214_F246_A1.0020.80
139_F185_L1.0020.80
5_S35_F0.9830.79
15_L220_W0.9810.79
196_S199_L0.9810.79
74_G83_L0.9770.78
68_F172_L0.9700.78
177_G211_N0.9660.78
240_V254_L0.9650.78
9_G12_G0.9620.77
33_S234_S0.9560.77
4_V226_A0.9550.77
31_G259_Q0.9540.77
22_A102_Y0.9470.76
77_L80_G0.9380.75
120_N126_P0.9360.75
226_A236_T0.9360.75
67_R86_K0.9170.74
24_Y33_S0.9090.73
4_V64_A0.9080.73
195_L201_V0.9050.73
199_L225_V0.9050.73
146_L156_L0.9040.73
200_A224_F0.9020.73
30_I53_V0.8990.72
2_G24_Y0.8890.71
98_G101_V0.8860.71
96_L196_S0.8820.71
73_L214_F0.8600.69
44_Y246_A0.8580.69
179_R213_G0.8550.68
70_T83_L0.8540.68
74_G77_L0.8510.68
66_Q89_I0.8500.68
103_D145_K0.8480.68
124_A128_A0.8440.67
170_F240_V0.8440.67
210_D216_R0.8420.67
69_D82_G0.8410.67
74_G215_A0.8240.66
108_L145_K0.8220.65
128_A246_A0.8210.65
24_Y231_K0.8180.65
162_L187_F0.8140.65
38_R254_L0.8130.65
242_L245_I0.8120.64
34_A51_A0.8110.64
4_V234_S0.8080.64
93_K140_Y0.8070.64
120_N175_F0.8050.64
61_L92_A0.8040.64
169_Q218_D0.8020.63
74_G125_V0.8010.63
22_A228_F0.7970.63
46_L68_F0.7900.62
192_A232_N0.7900.62
160_A189_G0.7890.62
104_Q108_L0.7790.61
240_V250_D0.7770.61
169_Q208_K0.7760.61
203_A221_W0.7750.61
228_F231_K0.7740.61
48_S64_A0.7730.61
135_S180_N0.7710.60
160_A187_F0.7700.60
104_Q107_W0.7580.59
153_G158_L0.7580.59
25_G29_E0.7560.59
73_L82_G0.7550.59
37_T161_T0.7540.59
138_D183_Y0.7530.59
73_L248_L0.7520.58
133_D181_D0.7520.58
229_P238_A0.7510.58
2_G234_S0.7510.58
151_L203_A0.7480.58
100_A144_T0.7480.58
16_T161_T0.7480.58
32_A89_I0.7470.58
157_L192_A0.7450.58
233_L258_L0.7450.58
177_G213_G0.7440.58
2_G11_A0.7430.58
8_E116_Q0.7400.57
135_S160_A0.7400.57
157_L226_A0.7380.57
4_V244_N0.7370.57
147_F160_A0.7350.57
96_L111_V0.7340.57
70_T215_A0.7340.57
77_L247_T0.7310.56
136_G139_F0.7300.56
10_A116_Q0.7290.56
115_V141_L0.7290.56
4_V7_I0.7280.56
155_S193_Y0.7240.56
245_I251_Q0.7230.56
180_N211_N0.7220.55
52_A228_F0.7130.54
204_E222_D0.7100.54
191_A203_A0.7090.54
146_L155_S0.7090.54
8_E170_F0.7010.53
74_G78_G0.7000.53
85_L122_D0.6990.53
218_D244_N0.6970.53
5_S33_S0.6940.52
70_T78_G0.6910.52
223_V237_A0.6900.52
58_R95_R0.6890.52
122_D125_V0.6880.52
39_V245_I0.6880.52
249_R252_R0.6870.52
113_V139_F0.6860.52
210_D218_D0.6830.51
58_R94_V0.6810.51
50_G256_L0.6800.51
15_L170_F0.6770.51
203_A223_V0.6750.50
16_T142_S0.6730.50
22_A54_G0.6710.50
244_N248_L0.6710.50
65_R86_K0.6710.50
166_K239_Y0.6680.50
168_N211_N0.6660.50
47_D189_G0.6660.50
142_S153_G0.6640.49
70_T85_L0.6580.49
172_L244_N0.6570.49
24_Y194_L0.6550.48
73_L246_A0.6530.48
132_K181_D0.6530.48
90_F119_R0.6520.48
196_S225_V0.6510.48
71_G77_L0.6470.48
165_T209_P0.6460.47
147_F156_L0.6450.47
125_V129_L0.6450.47
36_A39_V0.6440.47
12_G19_A0.6390.47
144_T157_L0.6380.47
210_D215_A0.6360.46
49_Y67_R0.6340.46
234_S255_Y0.6330.46
170_F208_K0.6310.46
95_R98_G0.6300.46
156_L194_L0.6300.46
16_T103_D0.6290.46
10_A15_L0.6290.46
214_F248_L0.6270.45
231_K255_Y0.6250.45
178_D181_D0.6250.45
97_A112_A0.6250.45
195_L227_W0.6240.45
85_L129_L0.6230.45
25_G28_D0.6210.45
215_A244_N0.6210.45
44_Y247_T0.6200.45
68_F126_P0.6180.45
235_L256_L0.6160.44
168_N176_G0.6140.44
73_L244_N0.6120.44
88_D92_A0.6100.44
3_G11_A0.6090.44
244_N247_T0.6090.44
4_V203_A0.6050.43
222_D239_Y0.6000.43
121_D234_S0.6000.43
57_D123_G0.5980.42
75_A78_G0.5970.42
122_D215_A0.5960.42
199_L233_L0.5960.42
8_E138_D0.5960.42
178_D214_F0.5950.42
178_D215_A0.5950.42
7_I39_V0.5940.42
13_G18_W0.5940.42
179_R184_S0.5930.42
35_F38_R0.5910.42
220_W240_V0.5890.42
70_T247_T0.5890.42
2_G25_G0.5860.41
124_A201_V0.5860.41
169_Q245_I0.5840.41
61_L181_D0.5800.41
3_G194_L0.5790.41
124_A127_R0.5760.40
79_L83_L0.5750.40
18_W161_T0.5750.40
154_R196_S0.5730.40
7_I220_W0.5720.40
104_Q156_L0.5720.40
153_G156_L0.5720.40
41_T253_G0.5700.40
239_Y254_L0.5700.40
99_D148_L0.5660.39
75_A80_G0.5650.39
190_S224_F0.5640.39
202_G224_F0.5630.39
51_A90_F0.5620.39
45_S119_R0.5620.39
189_G205_Y0.5600.39
118_K161_T0.5590.39
6_Q204_E0.5590.39
82_G105_D0.5580.38
114_G140_Y0.5580.38
215_A220_W0.5580.38
139_F183_Y0.5570.38
64_A146_L0.5560.38
133_D218_D0.5540.38
97_A103_D0.5540.38
120_N123_G0.5530.38
169_Q244_N0.5520.38
110_Q257_S0.5520.38
41_T81_P0.5510.38
79_L87_Q0.5510.38
25_G31_G0.5500.38
180_N183_Y0.5460.37
145_K165_T0.5450.37
72_D248_L0.5440.37
6_Q10_A0.5440.37
169_Q209_P0.5440.37
236_T255_Y0.5430.37
6_Q15_L0.5420.37
51_A139_F0.5400.37
129_L190_S0.5400.37
147_F154_R0.5400.37
2_G26_T0.5380.36
123_G126_P0.5330.36
178_D211_N0.5300.36
85_L215_A0.5300.36
79_L85_L0.5290.36
115_V139_F0.5280.36
14_G190_S0.5260.35
14_G18_W0.5260.35
57_D236_T0.5240.35
70_T126_P0.5230.35
46_L89_I0.5220.35
188_E217_E0.5210.35
65_R166_K0.5210.35
154_R193_Y0.5200.35
208_K245_I0.5190.35
154_R158_L0.5180.35
63_Y85_L0.5180.35
38_R45_S0.5170.34
74_G80_G0.5170.34
93_K99_D0.5160.34
45_S182_S0.5160.34
2_G228_F0.5130.34
73_L247_T0.5130.34
76_A79_L0.5120.34
15_L143_A0.5110.34
15_L40_N0.5110.34
2_G33_S0.5100.34
80_G85_L0.5090.34
77_L83_L0.5090.34
135_S184_S0.5080.34
84_T124_A0.5080.34
104_Q148_L0.5080.34
7_I15_L0.5070.34
112_A140_Y0.5050.33
139_F166_K0.5050.33
89_I116_Q0.5040.33
121_D124_A0.5040.33
164_A181_D0.5030.33
151_L155_S0.5030.33
200_A232_N0.5020.33
68_F236_T0.5010.33
47_D233_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pguA 1 0.9575 39.8 0.963 Contact Map
3dwoX 1 0.9768 24.8 0.966 Contact Map
4rl8A 3 0.8919 13.2 0.97 Contact Map
4rl9A 1 0.4324 8.8 0.973 Contact Map
3bryA 1 0.8919 8.7 0.973 Contact Map
1p4tA 2 0.556 7.9 0.973 Contact Map
3qraA 1 0.5097 7.7 0.973 Contact Map
3j38B 1 0.2046 7.6 0.973 Contact Map
4rlcA 1 0.4595 7.4 0.974 Contact Map
4ujpC 1 0.1892 7.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.