GREMLIN Database
DUF3027 - Protein of unknown function (DUF3027)
PFAM: PF11228 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (192)
Sequences: 1780 (888)
Seq/√Len: 64.1
META: 0.696

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_L182_L4.3581.00
175_D184_H4.0541.00
17_L29_R3.7511.00
13_V46_D3.3671.00
114_A191_E3.3621.00
6_V14_V3.0481.00
12_R39_R3.0161.00
127_E131_D2.9801.00
15_T31_A2.9271.00
134_H178_R2.8951.00
89_L152_G2.8801.00
36_R39_R2.7221.00
134_H175_D2.6131.00
12_R41_K2.4371.00
75_G78_D2.3921.00
88_R153_F2.3701.00
138_S141_A2.3461.00
155_V169_A2.3331.00
37_A40_A2.2841.00
79_L145_P2.2791.00
117_L169_A2.2651.00
4_L19_A2.2601.00
12_R36_R2.2111.00
8_A14_V2.2081.00
36_R41_K2.1431.00
134_H184_H2.0681.00
34_V43_V2.0671.00
3_H16_H1.8831.00
2_E19_A1.8601.00
35_A46_D1.8581.00
145_P192_A1.8131.00
87_P120_E1.7681.00
3_H6_V1.7120.99
82_T172_Y1.5680.99
99_P103_R1.5470.99
38_P41_K1.5120.99
102_V105_V1.4960.98
96_T102_V1.4900.98
154_L167_V1.4640.98
75_G174_P1.4580.98
137_D142_R1.4450.98
76_P174_P1.4320.98
140_M175_D1.4230.98
93_Y96_T1.4210.98
139_P143_A1.4150.98
175_D183_D1.4000.98
26_R55_D1.3850.97
118_S121_G1.3680.97
96_T100_A1.3600.97
130_Y183_D1.3520.97
80_L172_Y1.3420.97
92_G116_V1.3200.97
140_M184_H1.3180.97
87_P153_F1.3010.96
40_A43_V1.3000.96
125_A169_A1.2940.96
134_H177_G1.2640.96
155_V161_L1.2480.95
96_T103_R1.2450.95
82_T192_A1.2340.95
125_A152_G1.2290.95
20_C24_G1.2260.95
175_D178_R1.2130.94
126_A161_L1.2060.94
181_S184_H1.2000.94
139_P142_R1.1890.94
146_A150_T1.1850.94
91_P94_T1.1710.93
187_G190_S1.1690.93
13_V35_A1.1670.93
157_L167_V1.1600.93
7_V29_R1.1590.93
102_V106_A1.1280.92
130_Y184_H1.1190.92
186_C189_H1.1030.91
130_Y181_S1.1020.91
132_G138_S1.0960.91
164_A183_D1.0950.91
77_G145_P1.0790.90
39_R42_T1.0770.90
134_H181_S1.0550.89
72_G188_A1.0310.88
93_Y112_G1.0280.88
9_E15_T1.0200.87
14_V34_V1.0170.87
17_L31_A1.0170.87
20_C50_L1.0150.87
48_V143_A0.9910.86
123_D126_A0.9750.85
47_E172_Y0.9650.84
186_C190_S0.9600.84
108_E112_G0.9540.84
158_A162_G0.9520.84
37_A43_V0.9480.83
74_L188_A0.9480.83
90_V116_V0.9480.83
120_E123_D0.9360.83
76_P87_P0.9330.82
69_L80_L0.9320.82
76_P140_M0.9210.81
13_V36_R0.9080.81
119_R123_D0.8960.80
10_G13_V0.8940.80
101_V104_E0.8920.79
130_Y136_P0.8910.79
29_R54_P0.8890.79
76_P143_A0.8890.79
132_G136_P0.8880.79
17_L56_A0.8870.79
16_H43_V0.8700.78
115_R191_E0.8680.77
92_G111_L0.8650.77
65_W93_Y0.8620.77
107_W110_G0.8620.77
31_A51_L0.8610.77
76_P82_T0.8600.77
130_Y175_D0.8560.76
12_R38_P0.8480.76
20_C48_V0.8470.76
147_P150_T0.8470.76
69_L78_D0.8420.75
97_D103_R0.8390.75
93_Y110_G0.8270.74
117_L121_G0.8230.74
16_H36_R0.8200.73
97_D105_V0.8170.73
24_G119_R0.8010.72
124_E171_E0.8010.72
29_R33_T0.7960.71
134_H138_S0.7960.71
107_W163_Q0.7930.71
17_L23_P0.7910.71
31_A49_V0.7910.71
82_T88_R0.7900.71
5_G29_R0.7830.70
116_V119_R0.7830.70
79_L127_E0.7690.68
77_G140_M0.7660.68
61_E67_E0.7570.67
117_L125_A0.7520.67
15_T53_G0.7420.66
185_G189_H0.7410.66
76_P120_E0.7390.65
31_A173_S0.7330.65
92_G95_A0.7320.65
107_W192_A0.7290.64
171_E192_A0.7290.64
108_E116_V0.7230.64
148_C151_C0.7190.63
12_R37_A0.7190.63
120_E124_E0.7180.63
177_G180_V0.7160.63
117_L155_V0.7120.63
156_P162_G0.7110.62
41_K123_D0.7100.62
108_E111_L0.7070.62
152_G165_F0.7060.62
36_R40_A0.7060.62
90_V123_D0.7050.62
185_G188_A0.7040.62
19_A61_E0.7030.62
116_V159_G0.7020.61
95_A125_A0.7020.61
100_A103_R0.7010.61
99_P102_V0.6980.61
25_Y28_W0.6910.60
61_E84_A0.6890.60
20_C31_A0.6870.60
107_W162_G0.6840.59
93_Y108_E0.6840.59
130_Y134_H0.6790.59
74_L138_S0.6730.58
25_Y30_W0.6720.58
122_R130_Y0.6690.58
143_A153_F0.6670.57
82_T115_R0.6670.57
26_R57_L0.6620.57
88_R170_N0.6590.57
146_A157_L0.6580.56
97_D100_A0.6580.56
112_G162_G0.6560.56
45_V94_T0.6560.56
31_A103_R0.6550.56
112_G122_R0.6550.56
82_T188_A0.6550.56
100_A104_E0.6540.56
55_D150_T0.6530.56
76_P126_A0.6520.56
81_P191_E0.6520.56
171_E188_A0.6520.56
4_L80_L0.6510.56
96_T99_P0.6480.55
15_T51_L0.6460.55
97_D101_V0.6450.55
131_D156_P0.6440.55
37_A41_K0.6390.54
77_G141_A0.6380.54
120_E127_E0.6370.54
158_A163_Q0.6320.53
138_S175_D0.6310.53
63_V66_S0.6310.53
2_E21_T0.6310.53
56_A147_P0.6300.53
17_L33_T0.6260.53
77_G118_S0.6250.53
126_A131_D0.6250.53
66_S83_A0.6240.53
48_V142_R0.6230.52
178_R181_S0.6220.52
88_R124_E0.6170.52
96_T119_R0.6160.52
57_L66_S0.6020.50
131_D137_D0.6010.50
92_G114_A0.5970.49
47_E191_E0.5950.49
43_V46_D0.5890.48
31_A133_D0.5850.48
153_F175_D0.5850.48
95_A101_V0.5840.48
120_E131_D0.5840.48
23_P59_A0.5840.48
94_T102_V0.5830.48
7_V17_L0.5790.47
94_T100_A0.5790.47
146_A192_A0.5780.47
101_V105_V0.5770.47
152_G156_P0.5750.47
141_A185_G0.5730.47
65_W116_V0.5720.47
76_P192_A0.5670.46
33_T49_V0.5670.46
16_H38_P0.5660.46
141_A144_A0.5650.46
90_V119_R0.5650.46
76_P98_D0.5640.46
161_L169_A0.5630.45
29_R56_A0.5630.45
123_D127_E0.5630.45
82_T164_A0.5620.45
169_A182_L0.5600.45
98_D101_V0.5600.45
154_L166_G0.5590.45
67_E71_P0.5590.45
172_Y192_A0.5550.45
65_W76_P0.5540.44
14_V167_V0.5520.44
144_A185_G0.5520.44
70_R88_R0.5470.44
114_A123_D0.5460.44
24_G107_W0.5460.44
69_L76_P0.5450.43
23_P160_S0.5450.43
95_A102_V0.5440.43
35_A40_A0.5430.43
46_D102_V0.5420.43
77_G88_R0.5420.43
97_D152_G0.5420.43
58_L181_S0.5420.43
17_L51_L0.5420.43
111_L165_F0.5370.43
72_G75_G0.5370.43
31_A150_T0.5370.43
7_V54_P0.5320.42
47_E126_A0.5310.42
63_V91_P0.5310.42
49_V94_T0.5300.42
176_D180_V0.5290.42
154_L160_S0.5280.41
103_R106_A0.5280.41
15_T33_T0.5240.41
45_V69_L0.5220.41
57_L100_A0.5210.41
92_G117_L0.5210.41
5_G17_L0.5200.41
24_G93_Y0.5180.40
67_E70_R0.5170.40
46_D66_S0.5170.40
124_E127_E0.5170.40
45_V67_E0.5150.40
74_L78_D0.5140.40
76_P139_P0.5110.40
74_L141_A0.5080.39
32_V48_V0.5080.39
149_G182_L0.5070.39
100_A178_R0.5030.39
77_G82_T0.5010.38
65_W96_T0.5010.38
96_T105_V0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bh5A 4 0.2539 8.1 0.973 Contact Map
1hpiA 1 0.3679 8 0.973 Contact Map
3d0fA 2 0.4508 5.3 0.975 Contact Map
1isuA 2 0.2746 5.3 0.975 Contact Map
1f3zA 2 0.2642 3.8 0.977 Contact Map
1wg2A 1 0.2902 3.7 0.977 Contact Map
1whjA 1 0.228 3.4 0.977 Contact Map
2hx0A 3 0.544 2.9 0.978 Contact Map
1dgwX 1 0.3523 2.8 0.978 Contact Map
3pkaA 3 0.6321 2.8 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.