GREMLIN Database
DUF3024 - Protein of unknown function (DUF3024)
PFAM: PF11225 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 4336 (3099)
Seq/√Len: 417.9
META: 0.944

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_D29_H2.8341.00
46_E51_P2.2921.00
8_L43_L2.2731.00
5_V56_W2.2011.00
19_L43_L2.1701.00
34_L46_E2.0801.00
8_L47_V1.8421.00
22_M26_L1.8421.00
16_V36_P1.8381.00
39_S42_E1.6431.00
37_V43_L1.5721.00
19_L46_E1.5451.00
23_R29_H1.4391.00
4_P22_M1.4291.00
8_L40_L1.4091.00
43_L47_V1.3551.00
18_K30_R1.3311.00
45_A49_E1.3161.00
37_V42_E1.2361.00
22_M28_W1.1581.00
34_L37_V1.1271.00
7_K20_Y1.0731.00
46_E49_E1.0341.00
7_K28_W1.0321.00
21_W54_C1.0301.00
50_D53_G1.0141.00
20_Y30_R1.0111.00
11_V16_V1.0041.00
9_R28_W1.0001.00
41_E45_A0.9981.00
11_V14_T0.9931.00
31_Y50_D0.9551.00
40_L44_L0.9491.00
34_L43_L0.9141.00
4_P26_L0.9101.00
12_K15_G0.8961.00
31_Y55_F0.8941.00
34_L51_P0.8851.00
10_Y17_W0.8691.00
10_Y15_G0.8641.00
4_P7_K0.8621.00
16_V38_K0.8321.00
30_R35_P0.8281.00
50_D54_C0.8171.00
50_D55_F0.8111.00
21_W25_D0.8051.00
8_L19_L0.8041.00
35_P38_K0.8021.00
44_L48_D0.7721.00
34_L38_K0.7681.00
21_W29_H0.7601.00
32_E52_T0.7411.00
14_T36_P0.7411.00
9_R18_K0.7261.00
11_V18_K0.7111.00
28_W40_L0.7101.00
31_Y46_E0.6961.00
3_S26_L0.6801.00
42_E45_A0.6711.00
6_A47_V0.6701.00
47_V50_D0.6610.99
3_S22_M0.6550.99
6_A19_L0.6440.99
19_L37_V0.6250.99
9_R20_Y0.6230.99
11_V30_R0.5920.99
7_K10_Y0.5820.99
14_T38_K0.5770.99
36_P39_S0.5760.99
45_A48_D0.5760.99
14_T18_K0.5730.98
34_L41_E0.5600.98
53_G56_W0.5460.98
35_P39_S0.5430.98
31_Y51_P0.5430.98
6_A43_L0.5350.98
31_Y54_C0.5340.98
2_E9_R0.5330.98
33_P52_T0.5280.97
11_V33_P0.5160.97
19_L34_L0.5150.97
21_W38_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dk6A 1 0.9107 19.1 0.839 Contact Map
2a90A 1 0.9464 16.8 0.843 Contact Map
4qhwA 1 0.9286 13.8 0.849 Contact Map
1o0sA 4 1 11.5 0.854 Contact Map
1pj3A 4 1 10 0.858 Contact Map
3bowA 1 0.875 6.8 0.869 Contact Map
1qxpA 1 0.8571 6.6 0.869 Contact Map
2r9fA 1 0.875 6.4 0.87 Contact Map
1zivA 1 0.8929 3.8 0.883 Contact Map
2nqaA 3 0.8571 3.8 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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