GREMLIN Database
DUF3017 - Protein of unknown function (DUF3017)
PFAM: PF11222 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 2858 (1779)
Seq/√Len: 209.6
META: 0.79

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L65_G4.2301.00
7_G30_A4.1371.00
35_A62_A3.5371.00
28_G69_L2.8511.00
19_H22_R2.3911.00
39_L58_V1.8881.00
11_G27_I1.8611.00
14_L22_R1.7501.00
24_T72_A1.7031.00
56_V60_T1.6711.00
35_A58_V1.6521.00
14_L26_V1.5841.00
25_L73_L1.5691.00
59_V63_V1.5551.00
24_T48_L1.5291.00
66_A70_V1.5061.00
8_V27_I1.4491.00
60_T64_L1.3341.00
15_V23_G1.3181.00
7_G33_L1.3081.00
42_P45_R1.2611.00
46_A50_A1.2201.00
34_A61_L1.2091.00
9_A13_V1.2051.00
10_V14_L1.1931.00
63_V66_A1.1911.00
11_G30_A1.1891.00
5_L9_A1.1851.00
4_V34_A1.1411.00
37_L41_L1.1401.00
22_R26_V1.0901.00
3_L7_G1.0851.00
34_A50_A1.0341.00
63_V67_A1.0251.00
14_L18_G1.0171.00
58_V62_A1.0031.00
43_E50_A1.0011.00
2_L6_A0.9881.00
35_A61_L0.9841.00
61_L68_L0.9831.00
28_G65_G0.9701.00
33_L37_L0.9531.00
53_S56_V0.9450.99
43_E55_A0.9120.99
19_H25_L0.9040.99
51_V61_L0.9030.99
6_A10_V0.8960.99
13_V17_L0.8940.99
7_G31_L0.8860.99
31_L35_A0.8730.99
56_V59_V0.8510.99
8_V12_L0.7990.98
60_T63_V0.7840.98
20_W24_T0.7790.98
34_A46_A0.7790.98
34_A49_L0.7590.98
44_R53_S0.7430.97
30_A34_A0.7290.97
26_V64_L0.7170.97
65_G69_L0.7160.96
25_L29_A0.7120.96
22_R25_L0.7070.96
25_L72_A0.7030.96
10_V13_V0.6990.96
2_L18_G0.6980.96
20_W28_G0.6940.96
36_V40_V0.6870.96
47_G50_A0.6630.95
15_V24_T0.6570.94
67_A70_V0.6530.94
20_W25_L0.6430.94
41_L46_A0.6360.93
42_P46_A0.6350.93
42_P55_A0.6230.93
11_G23_G0.6120.92
15_V20_W0.5990.91
11_G34_A0.5940.91
32_L62_A0.5900.91
20_W60_T0.5900.91
24_T69_L0.5890.90
15_V18_G0.5890.90
11_G47_G0.5850.90
61_L71_L0.5850.90
21_R25_L0.5840.90
14_L19_H0.5830.90
35_A65_G0.5720.89
5_L8_V0.5680.89
21_R24_T0.5680.89
31_L61_L0.5660.89
62_A66_A0.5580.88
32_L69_L0.5510.87
46_A54_R0.5490.87
30_A51_V0.5400.86
29_A33_L0.5380.86
53_S58_V0.5360.86
8_V23_G0.5360.86
25_L67_A0.5350.86
45_R53_S0.5330.86
12_L17_L0.5300.85
64_L73_L0.5280.85
33_L42_P0.5260.85
18_G61_L0.5240.85
22_R27_I0.5230.84
16_A19_H0.5220.84
6_A36_V0.5190.84
20_W51_V0.5080.83
31_L47_G0.5010.82
29_A36_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hb3B 1 0 1.3 0.903 Contact Map
4i0uA 4 0.6081 1 0.91 Contact Map
4ev6A 3 0.6351 0.9 0.912 Contact Map
4phzB 3 0.4595 0.7 0.916 Contact Map
4pypA 1 0.9865 0.7 0.917 Contact Map
4pj0Y 1 0.3378 0.7 0.917 Contact Map
1orsC 1 0.3514 0.7 0.918 Contact Map
3wu2Y 1 0.3378 0.7 0.919 Contact Map
4bbjA 1 0.9459 0.6 0.92 Contact Map
4j05A 3 0.7838 0.6 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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