GREMLIN Database
DUF3015 - Protein of unknown function (DUF3015)
PFAM: PF11220 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (136)
Sequences: 2576 (1822)
Seq/√Len: 156.2
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_G39_T3.5041.00
76_M105_L2.6421.00
11_L47_S2.6131.00
40_F44_S2.5901.00
64_F86_T2.5121.00
108_N111_T2.4271.00
27_L31_T2.2811.00
105_L127_L2.2681.00
26_V29_A2.2341.00
65_V123_V2.0961.00
75_D78_R2.0271.00
7_A28_A2.0011.00
37_N47_S1.9531.00
37_N41_G1.9441.00
27_L30_T1.8551.00
98_R102_A1.8211.00
114_P118_V1.8161.00
100_A134_D1.7441.00
119_T122_E1.7331.00
88_A101_F1.7291.00
87_L127_L1.7261.00
16_F31_T1.6731.00
9_C49_C1.6631.00
74_R78_R1.6561.00
34_T37_N1.6051.00
22_L26_V1.5991.00
13_S48_G1.5961.00
94_P97_D1.5831.00
18_G21_G1.5721.00
64_F68_N1.5651.00
84_L102_A1.5531.00
38_Q42_I1.5321.00
76_M113_F1.5261.00
19_Q24_P1.4821.00
33_G37_N1.4641.00
118_V126_N1.4621.00
114_P126_N1.4511.00
69_M113_F1.4131.00
36_G40_F1.3991.00
41_G46_T1.3891.00
37_N40_F1.3791.00
112_I123_V1.3791.00
72_L76_M1.3531.00
87_L91_L1.3501.00
4_Y7_A1.3161.00
72_L87_L1.3161.00
11_L15_L1.3121.00
23_V26_V1.3101.00
85_D98_R1.2441.00
108_N130_V1.2421.00
103_A107_E1.2241.00
25_Q42_I1.2181.00
41_G49_C1.2181.00
29_A39_T1.2161.00
65_V124_L1.1981.00
91_L128_K1.1861.00
85_D102_A1.1801.00
122_E125_D1.1421.00
93_V97_D1.1321.00
89_E98_R1.1261.00
21_G24_P1.1211.00
23_V27_L1.1101.00
40_F46_T1.1010.99
64_F90_L1.1000.99
115_S118_V1.0920.99
16_F28_A1.0910.99
69_M120_A1.0800.99
124_L128_K1.0730.99
118_V123_V1.0600.99
50_T53_G1.0330.99
33_G36_G1.0290.99
6_G25_Q1.0280.99
125_D128_K1.0240.99
59_E62_A1.0180.99
65_V72_L1.0080.99
38_Q41_G1.0050.99
73_A113_F0.9930.99
28_A32_N0.9750.99
73_A109_F0.9580.99
100_A104_L0.9550.99
13_S28_A0.9420.98
99_A102_A0.9320.98
84_L105_L0.9310.98
63_V66_A0.9230.98
61_A128_K0.9020.98
126_N130_V0.9010.98
62_A121_A0.8930.98
104_L130_V0.8870.98
4_Y13_S0.8850.98
61_A91_L0.8850.98
135_P138_A0.8830.98
101_F105_L0.8780.97
21_G28_A0.8650.97
85_D88_A0.8530.97
6_G13_S0.8500.97
8_G11_L0.8480.97
76_M127_L0.8410.97
83_T87_L0.8330.97
22_L25_Q0.8260.96
11_L35_F0.8190.96
115_S122_E0.8130.96
86_T90_L0.8100.96
11_L41_G0.8090.96
130_V133_A0.8090.96
62_A66_A0.7900.95
80_Q102_A0.7880.95
15_L37_N0.7850.95
33_G41_G0.7840.95
24_P27_L0.7790.95
31_T34_T0.7790.95
16_F24_P0.7750.95
38_Q47_S0.7730.95
45_G49_C0.7600.94
4_Y25_Q0.7500.94
11_L34_T0.7480.94
11_L14_M0.7420.93
14_M48_G0.7390.93
6_G50_T0.7380.93
125_D129_A0.7360.93
39_T43_T0.7340.93
20_S24_P0.7330.93
16_F21_G0.7320.93
11_L31_T0.7310.93
35_F41_G0.7190.92
55_V58_N0.7120.92
97_D100_A0.7120.92
29_A34_T0.7120.92
7_A25_Q0.7060.92
63_V67_A0.7060.92
29_A38_Q0.7040.92
20_S23_V0.6980.91
3_A6_G0.6950.91
83_T86_T0.6930.91
75_D109_F0.6780.90
36_G44_S0.6720.90
102_A105_L0.6700.89
9_C41_G0.6610.89
31_T35_F0.6600.89
26_V30_T0.6590.89
69_M123_V0.6570.89
95_D98_R0.6570.89
100_A103_A0.6530.88
127_L132_A0.6410.87
112_I130_V0.6400.87
121_A125_D0.6360.87
122_E126_N0.6340.87
19_Q22_L0.6340.87
126_N129_A0.6260.86
15_L35_F0.6200.85
40_F43_T0.6200.85
93_V101_F0.6190.85
31_T37_N0.6190.85
71_N83_T0.6180.85
5_G13_S0.6150.85
25_Q28_A0.6110.85
93_V102_A0.6070.84
115_S119_T0.6070.84
6_G20_S0.6040.84
103_A129_A0.6040.84
65_V87_L0.5990.83
113_F123_V0.5980.83
39_T44_S0.5980.83
45_G48_G0.5920.83
129_A133_A0.5910.83
85_D90_L0.5860.82
22_L51_Q0.5850.82
41_G45_G0.5840.82
82_E91_L0.5790.81
32_N38_Q0.5780.81
85_D89_E0.5750.81
7_A42_I0.5730.81
4_Y48_G0.5680.80
14_M17_K0.5670.80
37_N44_S0.5640.80
86_T89_E0.5620.79
39_T42_I0.5600.79
72_L84_L0.5560.79
22_L27_L0.5550.79
30_T41_G0.5550.79
95_D100_A0.5540.78
85_D96_A0.5480.78
132_A136_V0.5460.77
47_S50_T0.5420.77
73_A77_A0.5380.76
61_A86_T0.5350.76
15_L31_T0.5330.76
94_P99_A0.5310.76
41_G47_S0.5280.75
11_L37_N0.5230.74
7_A13_S0.5230.74
75_D83_T0.5230.74
42_I45_G0.5220.74
130_V135_P0.5210.74
68_N72_L0.5200.74
42_I53_G0.5180.74
114_P122_E0.5170.74
100_A136_V0.5150.73
130_V134_D0.5130.73
111_T126_N0.5110.73
111_T114_P0.5090.72
80_Q85_D0.5090.72
61_A124_L0.5050.72
36_G46_T0.5010.71
120_A127_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aj5K 4 0.4255 10.3 0.936 Contact Map
2k85A 1 0.305 10 0.936 Contact Map
2ccyA 2 0.6525 8.3 0.938 Contact Map
4i98B 2 0.5248 7.7 0.939 Contact Map
1mqvA 1 0.617 7.3 0.94 Contact Map
1s05A 1 0.617 6.4 0.942 Contact Map
3licA 2 0.5319 6 0.942 Contact Map
2jn6A 1 0.5603 5.9 0.943 Contact Map
1r5qA 2 0.3191 5.8 0.943 Contact Map
1t6sA 4 0.5461 5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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